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Protein

STE20-related kinase adapter protein alpha

Gene

Strada

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-related kinase adapter protein alpha
Short name:
STRAD alpha
Alternative name(s):
STE20-related adapter protein
Gene namesi
Name:Strada
Synonyms:Lyk5Imported, Strad
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727905. Strada.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600391 – 393STE20-related kinase adapter protein alphaAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei381Phosphothreonine; by LKB1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TNZ6.
PRIDEiQ7TNZ6.

PTM databases

iPTMnetiQ7TNZ6.
PhosphoSitePlusiQ7TNZ6.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

Protein-protein interaction databases

IntActiQ7TNZ6. 2 interactors.
STRINGi10116.ENSRNOP00000011894.

Structurei

3D structure databases

ProteinModelPortaliQ7TNZ6.
SMRiQ7TNZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 341Protein kinasePROSITE-ProRule annotationAdd BLAST310

Domaini

The protein kinase domain is predicted to be catalytically inactive.Sequence analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
HOGENOMiHOG000237355.
HOVERGENiHBG055069.
InParanoidiQ7TNZ6.
KOiK08271.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q7TNZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLANEASS ESIASFSKPE IMSSFLPEGG CYELLSVIGK GFEDLMTVNS
60 70 80 90 100
RYKPTGEYVT VRRINLEACS NEMVTFLQGE LHVSKLFSHP NIVPYRATFI
110 120 130 140 150
ADNELWAVTS FMAYGSAKDL IGTHFMDGMS ELAIAYILQG VLKALDYIHH
160 170 180 190 200
MGYVHRSVKA SHILISTDGK VYLSGLRSNL SMISHGQRQR AVHDFPKYSI
210 220 230 240 250
KVLPWLSPEV LQQNLQGYDA KSDIYSVGIT ACELANGHVP FKDMPATQML
260 270 280 290 300
LEKLNGTVPC LLDTSTIPAE ELTMSPSRSI ANPGLNDSLA AGSLRPANGD
310 320 330 340 350
SPSHPYHRTF SPHFHNFVEQ CLQRNPDARP NASTLLNHSF FKQIKRRASE
360 370 380 390
ALPELLRPVT PITSFEGSQS QDHSGILGLV TNLEDLEVDD WEF
Length:393
Mass (Da):43,553
Last modified:October 1, 2003 - v1
Checksum:iB92AB012E2A8AD34
GO
Isoform 21 Publication (identifier: Q7TNZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:372
Mass (Da):41,326
Checksum:i1B990C714C58DDCB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50S → LA in AAH81911 (PubMed:15489334).Curated1
Sequence conflicti133A → V in AAH81911 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0522161 – 21Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327409 mRNA. Translation: AAP92801.1.
BC081911 mRNA. Translation: AAH81911.1.
RefSeqiNP_877972.1. NM_182820.1. [Q7TNZ6-1]
UniGeneiRn.11563.

Genome annotation databases

GeneIDi303605.
KEGGirno:303605.
UCSCiRGD:727905. rat. [Q7TNZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTRAA_RAT
AccessioniPrimary (citable) accession number: Q7TNZ6
Secondary accession number(s): Q66HD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families