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Protein

GTPase RhebL1

Gene

Rhebl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381MagnesiumBy similarity
Binding sitei63 – 631GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 216GTPBy similarity
Nucleotide bindingi32 – 387GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity
Nucleotide bindingi149 – 1502GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  2. small GTPase mediated signal transduction Source: InterPro
  3. TOR signaling Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name:
Rheb-like protein 1
Gene namesi
Name:Rhebl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi727778. Rhebl1.

Subcellular locationi

Endomembrane system By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. endomembrane system Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180GTPase RhebL1PRO_0000324296Add
BLAST
Propeptidei181 – 1833Removed in mature formBy similarityPRO_0000324297

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801Cysteine methyl esterBy similarity
Lipidationi180 – 1801S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiQ7TNZ5.

PTM databases

PhosphoSiteiQ7TNZ5.

Expressioni

Gene expression databases

GenevestigatoriQ7TNZ5.

Interactioni

Subunit structurei

Interacts with MTOR.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036452.

Structurei

3D structure databases

ProteinModelPortaliQ7TNZ5.
SMRiQ7TNZ5. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ7TNZ5.
KOiK07849.
OMAiRYRKVAI.
OrthoDBiEOG7Q2N6K.
PhylomeDBiQ7TNZ5.
TreeFamiTF314986.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLKGYDPTVE NTYSKTVTLG
60 70 80 90 100
KDEFHLHLVD TAGQDKYSIL PYSFIIGVHG YVLVYNVTSL RSFQIVKNLY
110 120 130 140 150
QKLQEGHGKT RLPVLLVGNK ADLSADREVQ AVEGKKLAES WGATFMESSA
160 170 180
RDNQLIQDIF IRVIQEIARV ENSYGQDRRC CLM
Length:183
Mass (Da):20,749
Last modified:October 1, 2003 - v1
Checksum:i9C051CABDBA8A6D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327411 mRNA. Translation: AAP92803.1.
RefSeqiNP_877977.1. NM_182825.1.
UniGeneiRn.43211.

Genome annotation databases

EnsembliENSRNOT00000035659; ENSRNOP00000036452; ENSRNOG00000021571.
GeneIDi359959.
KEGGirno:359959.
UCSCiRGD:727778. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327411 mRNA. Translation: AAP92803.1.
RefSeqiNP_877977.1. NM_182825.1.
UniGeneiRn.43211.

3D structure databases

ProteinModelPortaliQ7TNZ5.
SMRiQ7TNZ5. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036452.

PTM databases

PhosphoSiteiQ7TNZ5.

Proteomic databases

PRIDEiQ7TNZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035659; ENSRNOP00000036452; ENSRNOG00000021571.
GeneIDi359959.
KEGGirno:359959.
UCSCiRGD:727778. rat.

Organism-specific databases

CTDi121268.
RGDi727778. Rhebl1.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ7TNZ5.
KOiK07849.
OMAiRYRKVAI.
OrthoDBiEOG7Q2N6K.
PhylomeDBiQ7TNZ5.
TreeFamiTF314986.

Miscellaneous databases

NextBioi672712.
PROiQ7TNZ5.

Gene expression databases

GenevestigatoriQ7TNZ5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B."
    Yuan J., Shan Y., Chen X., Tang W., Luo K., Ni J., Wan B., Yu L.
    Mol. Biol. Rep. 32:205-214(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ovary.

Entry informationi

Entry nameiREBL1_RAT
AccessioniPrimary (citable) accession number: Q7TNZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: April 1, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.