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Q7TNZ5

- REBL1_RAT

UniProt

Q7TNZ5 - REBL1_RAT

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Protein

GTPase RhebL1

Gene

Rhebl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTPBy similarity
Nucleotide bindingi60 – 645GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  3. small GTPase mediated signal transduction Source: InterPro
  4. TOR signaling Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name:
Rheb-like protein 1
Gene namesi
Name:Rhebl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi727778. Rhebl1.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180GTPase RhebL1PRO_0000324296Add
BLAST
Propeptidei181 – 1833Removed in mature formBy similarityPRO_0000324297

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801Cysteine methyl esterBy similarity
Lipidationi180 – 1801S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiQ7TNZ5.

PTM databases

PhosphoSiteiQ7TNZ5.

Expressioni

Gene expression databases

GenevestigatoriQ7TNZ5.

Interactioni

Subunit structurei

Interacts with MTOR.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036452.

Structurei

3D structure databases

ProteinModelPortaliQ7TNZ5.
SMRiQ7TNZ5. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000120482.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ7TNZ5.
KOiK07849.
OMAiRYRKVAI.
OrthoDBiEOG7Q2N6K.
PhylomeDBiQ7TNZ5.
TreeFamiTF314986.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLKGYDPTVE NTYSKTVTLG
60 70 80 90 100
KDEFHLHLVD TAGQDKYSIL PYSFIIGVHG YVLVYNVTSL RSFQIVKNLY
110 120 130 140 150
QKLQEGHGKT RLPVLLVGNK ADLSADREVQ AVEGKKLAES WGATFMESSA
160 170 180
RDNQLIQDIF IRVIQEIARV ENSYGQDRRC CLM
Length:183
Mass (Da):20,749
Last modified:October 1, 2003 - v1
Checksum:i9C051CABDBA8A6D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327411 mRNA. Translation: AAP92803.1.
RefSeqiNP_877977.1. NM_182825.1.
UniGeneiRn.43211.

Genome annotation databases

EnsembliENSRNOT00000035659; ENSRNOP00000036452; ENSRNOG00000021571.
GeneIDi359959.
KEGGirno:359959.
UCSCiRGD:727778. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327411 mRNA. Translation: AAP92803.1 .
RefSeqi NP_877977.1. NM_182825.1.
UniGenei Rn.43211.

3D structure databases

ProteinModelPortali Q7TNZ5.
SMRi Q7TNZ5. Positions 5-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000036452.

PTM databases

PhosphoSitei Q7TNZ5.

Proteomic databases

PRIDEi Q7TNZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000035659 ; ENSRNOP00000036452 ; ENSRNOG00000021571 .
GeneIDi 359959.
KEGGi rno:359959.
UCSCi RGD:727778. rat.

Organism-specific databases

CTDi 121268.
RGDi 727778. Rhebl1.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00770000120482.
HOGENOMi HOG000233973.
HOVERGENi HBG009351.
InParanoidi Q7TNZ5.
KOi K07849.
OMAi RYRKVAI.
OrthoDBi EOG7Q2N6K.
PhylomeDBi Q7TNZ5.
TreeFami TF314986.

Miscellaneous databases

NextBioi 672712.
PROi Q7TNZ5.

Gene expression databases

Genevestigatori Q7TNZ5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B."
    Yuan J., Shan Y., Chen X., Tang W., Luo K., Ni J., Wan B., Yu L.
    Mol. Biol. Rep. 32:205-214(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ovary.

Entry informationi

Entry nameiREBL1_RAT
AccessioniPrimary (citable) accession number: Q7TNZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3