Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7TNZ5

- REBL1_RAT

UniProt

Q7TNZ5 - REBL1_RAT

Protein

GTPase RhebL1

Gene

Rhebl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208GTPBy similarity
    Nucleotide bindingi60 – 645GTPBy similarity
    Nucleotide bindingi119 – 1224GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    3. small GTPase mediated signal transduction Source: InterPro
    4. TOR signaling Source: Ensembl

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase RhebL1
    Alternative name(s):
    Ras homolog enriched in brain-like protein 1
    Short name:
    Rheb-like protein 1
    Gene namesi
    Name:Rhebl1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi727778. Rhebl1.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180GTPase RhebL1PRO_0000324296Add
    BLAST
    Propeptidei181 – 1833Removed in mature formBy similarityPRO_0000324297

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei180 – 1801Cysteine methyl esterBy similarity
    Lipidationi180 – 1801S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiQ7TNZ5.

    PTM databases

    PhosphoSiteiQ7TNZ5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TNZ5.

    Interactioni

    Subunit structurei

    Interacts with MTOR.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000036452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TNZ5.
    SMRiQ7TNZ5. Positions 5-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector region

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rheb family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00730000110570.
    HOGENOMiHOG000233973.
    HOVERGENiHBG009351.
    InParanoidiQ7TNZ5.
    KOiK07849.
    OMAiRYRKVAI.
    OrthoDBiEOG7Q2N6K.
    PhylomeDBiQ7TNZ5.
    TreeFamiTF314986.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7TNZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLKGYDPTVE NTYSKTVTLG    50
    KDEFHLHLVD TAGQDKYSIL PYSFIIGVHG YVLVYNVTSL RSFQIVKNLY 100
    QKLQEGHGKT RLPVLLVGNK ADLSADREVQ AVEGKKLAES WGATFMESSA 150
    RDNQLIQDIF IRVIQEIARV ENSYGQDRRC CLM 183
    Length:183
    Mass (Da):20,749
    Last modified:October 1, 2003 - v1
    Checksum:i9C051CABDBA8A6D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY327411 mRNA. Translation: AAP92803.1.
    RefSeqiNP_877977.1. NM_182825.1.
    UniGeneiRn.43211.

    Genome annotation databases

    EnsembliENSRNOT00000035659; ENSRNOP00000036452; ENSRNOG00000021571.
    GeneIDi359959.
    KEGGirno:359959.
    UCSCiRGD:727778. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY327411 mRNA. Translation: AAP92803.1 .
    RefSeqi NP_877977.1. NM_182825.1.
    UniGenei Rn.43211.

    3D structure databases

    ProteinModelPortali Q7TNZ5.
    SMRi Q7TNZ5. Positions 5-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000036452.

    PTM databases

    PhosphoSitei Q7TNZ5.

    Proteomic databases

    PRIDEi Q7TNZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000035659 ; ENSRNOP00000036452 ; ENSRNOG00000021571 .
    GeneIDi 359959.
    KEGGi rno:359959.
    UCSCi RGD:727778. rat.

    Organism-specific databases

    CTDi 121268.
    RGDi 727778. Rhebl1.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00730000110570.
    HOGENOMi HOG000233973.
    HOVERGENi HBG009351.
    InParanoidi Q7TNZ5.
    KOi K07849.
    OMAi RYRKVAI.
    OrthoDBi EOG7Q2N6K.
    PhylomeDBi Q7TNZ5.
    TreeFami TF314986.

    Miscellaneous databases

    NextBioi 672712.
    PROi Q7TNZ5.

    Gene expression databases

    Genevestigatori Q7TNZ5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B."
      Yuan J., Shan Y., Chen X., Tang W., Luo K., Ni J., Wan B., Yu L.
      Mol. Biol. Rep. 32:205-214(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Ovary.

    Entry informationi

    Entry nameiREBL1_RAT
    AccessioniPrimary (citable) accession number: Q7TNZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3