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Q7TNZ5 (REBL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name=Rheb-like protein 1
Gene names
Name:Rhebl1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 By similarity.

Subunit structure

Interacts with MTOR By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rheb family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180GTPase RhebL1
PRO_0000324296
Propeptide181 – 1833Removed in mature form By similarity
PRO_0000324297

Regions

Nucleotide binding13 – 208GTP By similarity
Nucleotide binding60 – 645GTP By similarity
Nucleotide binding119 – 1224GTP By similarity
Motif35 – 439Effector region

Amino acid modifications

Modified residue1801Cysteine methyl ester By similarity
Lipidation1801S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TNZ5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 9C051CABDBA8A6D3

FASTA18320,749
        10         20         30         40         50         60 
MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLKGYDPTVE NTYSKTVTLG KDEFHLHLVD 

        70         80         90        100        110        120 
TAGQDKYSIL PYSFIIGVHG YVLVYNVTSL RSFQIVKNLY QKLQEGHGKT RLPVLLVGNK 

       130        140        150        160        170        180 
ADLSADREVQ AVEGKKLAES WGATFMESSA RDNQLIQDIF IRVIQEIARV ENSYGQDRRC 


CLM 

« Hide

References

[1]"Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B."
Yuan J., Shan Y., Chen X., Tang W., Luo K., Ni J., Wan B., Yu L.
Mol. Biol. Rep. 32:205-214(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY327411 mRNA. Translation: AAP92803.1.
RefSeqNP_877977.1. NM_182825.1.
UniGeneRn.43211.

3D structure databases

ProteinModelPortalQ7TNZ5.
SMRQ7TNZ5. Positions 5-171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000036452.

PTM databases

PhosphoSiteQ7TNZ5.

Proteomic databases

PRIDEQ7TNZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000035659; ENSRNOP00000036452; ENSRNOG00000021571.
GeneID359959.
KEGGrno:359959.
UCSCRGD:727778. rat.

Organism-specific databases

CTD121268.
RGD727778. Rhebl1.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00730000110570.
HOGENOMHOG000233973.
HOVERGENHBG009351.
InParanoidQ7TNZ5.
KOK07849.
OMARYRKVAI.
OrthoDBEOG7Q2N6K.
PhylomeDBQ7TNZ5.
TreeFamTF314986.

Gene expression databases

GenevestigatorQ7TNZ5.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio672712.
PROQ7TNZ5.

Entry information

Entry nameREBL1_RAT
AccessionPrimary (citable) accession number: Q7TNZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families