Q7TNZ5 (REBL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase RhebL1

Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name=Rheb-like protein 1

Gene names

Name:

Rhebl1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 By similarity.
Subunit structure	Interacts with MTOR By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rheb family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	TOR signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	GTPase RhebL1		PRO_0000324296
	Propeptide	181 – 183	3	Removed in mature form By similarity		PRO_0000324297
Regions
	Nucleotide binding	13 – 20	8	GTP By similarity
	Nucleotide binding	60 – 64	5	GTP By similarity
	Nucleotide binding	119 – 122	4	GTP By similarity
	Motif	35 – 43	9	Effector region By similarity
Amino acid modifications
	Modified residue	180	1	Cysteine methyl ester By similarity
	Lipidation	180	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7TNZ5 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9C051CABDBA8A6D3	FASTA	183	20,749
	10 20 30 40 50 60 MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLKGYDPTVE NTYSKTVTLG KDEFHLHLVD 70 80 90 100 110 120 TAGQDKYSIL PYSFIIGVHG YVLVYNVTSL RSFQIVKNLY QKLQEGHGKT RLPVLLVGNK 130 140 150 160 170 180 ADLSADREVQ AVEGKKLAES WGATFMESSA RDNQLIQDIF IRVIQEIARV ENSYGQDRRC CLM

References

[1]

"Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B." Yuan J., Shan Y., Chen X., Tang W., Luo K., Ni J., Wan B., Yu L. Mol. Biol. Rep. 32:205-214(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY327411 mRNA. Translation: AAP92803.1.
IPI	IPI00382177.
RefSeq	NP_877977.1. NM_182825.1.
UniGene	Rn.43211.
3D structure databases
ProteinModelPortal	Q7TNZ5.
SMR	Q7TNZ5. Positions 5-171.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000036452.
PTM databases
PhosphoSite	Q7TNZ5.
Proteomic databases
PRIDE	Q7TNZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000035659; ENSRNOP00000036452; ENSRNOG00000021571.
GeneID	359959.
KEGG	rno:359959.
UCSC	RGD:727778. rat.
Organism-specific databases
CTD	121268.
RGD	727778. Rhebl1.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00660000095554.
HOGENOM	HOG000233973.
HOVERGEN	HBG009351.
InParanoid	Q7TNZ5.
KO	K07849.
OMA	ERRCRLM.
OrthoDB	EOG4VMFGG.
Gene expression databases
Genevestigator	Q7TNZ5.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras. [Graphical view]
PANTHER	PTHR24070. PTHR24070. 1 hit.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00173. RAS. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51421. RAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	672712.

Entry information

Entry name

REBL1_RAT

Accession

Primary (citable) accession number: Q7TNZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 1, 2003
Last modified:	May 29, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program