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Protein

Rab effector MyRIP

Gene

Myrip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity). Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-typeAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein kinase A binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: InterPro
  • positive regulation of insulin secretion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rab effector MyRIP
Alternative name(s):
Exophilin-8
Myosin-VIIa- and Rab-interacting protein
Synaptotagmin-like protein lacking C2 domains C
Short name:
SlaC2-c
Short name:
Slp homolog lacking C2 domains c
Gene namesi
Name:Myrip
Synonyms:Slac2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727731. Myrip.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • dense core granule Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB
  • secretory granule membrane Source: RGD
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Rab effector MyRIPPRO_0000281024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991PhosphoserineBy similarity
Modified residuei351 – 3511PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TNY7.
PRIDEiQ7TNY7.

PTM databases

iPTMnetiQ7TNY7.
PhosphoSiteiQ7TNY7.

Interactioni

Subunit structurei

Binds MYO5A, MYO7A and F-actin. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity). Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4.By similarity1 Publication

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025460.

Structurei

3D structure databases

ProteinModelPortaliQ7TNY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 124121RabBDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 560418Myosin-bindingBy similarityAdd
BLAST
Regioni193 – 20917PKA-bindingBy similarityAdd
BLAST
Regioni232 – 24817Negative regulation of PKA-bindingBy similarityAdd
BLAST
Regioni495 – 856362Actin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.Curated
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHBX. Eukaryota.
ENOG41126RD. LUCA.
HOGENOMiHOG000113712.
HOVERGENiHBG052562.
InParanoidiQ7TNY7.
PhylomeDBiQ7TNY7.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006788. Myrip/Melanophilin.
IPR010911. Rab_BD.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02318. FYVE_2. 1 hit.
PF04698. Rab_eff_C. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50916. RABBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKLDLSGL TDDETEHVLQ VVQRDFNLRK KEEDRLSEMK QRLAEENSKC
60 70 80 90 100
SILSKHQKFV ERCCMRCCSP FTFLVNARRR CGECKFSVCK SCCSYQKHEK
110 120 130 140 150
LWVCCVCQQA RLLRTQSLEW FYNNVKTRFK RFGSAKVLKN LYKKHRLESG
160 170 180 190 200
ACFDILGGGL YEPNLENEGS ISGSDSTFYR QSEGHSMMDT LAVALQVAEE
210 220 230 240 250
AIEEAISKAE SQRDSLDKQN EASYLRDHRQ ELAEELAGTI LQRIIRKQKD
260 270 280 290 300
KADLHAEEEE PECTRPQSSG VKARGEGTAA PPGRHKARAA LWRSQSAFSF
310 320 330 340 350
TTEDTLKTSS AEAAPRQPKD RAQRLLEESA LPSWRSMDGL DGKNLVPLLQ
360 370 380 390 400
SPDGNWMTLK DSSRQPPTRL LAKPKSRTFQ ALEVASSVAS AYDELGSDSE
410 420 430 440 450
EDFDYSEALS KLRPPSQGRL KQPQPQPAQA QSSGQGPLAT SPSNPEAMCS
460 470 480 490 500
DSETSSTSSS REAGCRAKLL WLQRKAPKNP SAEKTHLQGE LDVNFNPQAA
510 520 530 540 550
GGETSDSSDP EETLHTADRR ARRWRRARVG PEESNRGLPS PSAYPPALHT
560 570 580 590 600
AQVSDNVSET DISNEAQNSR SSTDSAEEKL RNRLYELAMK MSEKETSSGE
610 620 630 640 650
DQESESKTEP KNQKGSLSSE ENNQGVQEEL KKKCSAVSLC NISTEVLKVI
660 670 680 690 700
NATEELIAES AGPWEIPPVS TDRDNGMFPL GTDQRSLDKQ LTSLEENVYL
710 720 730 740 750
AAGTVYGLEG QLSELEDAAR CIHSSTGETE LADLEDQVAA AAAQVHHAEL
760 770 780 790 800
QISDIESRIS ALTIAGLNIA PCVRLTRRRD QKQRSQVQTI DTSRQQRRKL
810 820 830 840 850
PAPPVKAEKI EASSVTPIKT FNRNFLLQGS STNRPTASTS NTKDLMEPVL

ESAVMY
Length:856
Mass (Da):94,985
Last modified:October 1, 2003 - v1
Checksum:i501FEE28739E938B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY331984 mRNA. Translation: AAP94626.1.
RefSeqiNP_878264.1. NM_182844.1.
UniGeneiRn.161974.

Genome annotation databases

GeneIDi360034.
KEGGirno:360034.
UCSCiRGD:727731. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY331984 mRNA. Translation: AAP94626.1.
RefSeqiNP_878264.1. NM_182844.1.
UniGeneiRn.161974.

3D structure databases

ProteinModelPortaliQ7TNY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025460.

PTM databases

iPTMnetiQ7TNY7.
PhosphoSiteiQ7TNY7.

Proteomic databases

PaxDbiQ7TNY7.
PRIDEiQ7TNY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360034.
KEGGirno:360034.
UCSCiRGD:727731. rat.

Organism-specific databases

CTDi25924.
RGDi727731. Myrip.

Phylogenomic databases

eggNOGiENOG410IHBX. Eukaryota.
ENOG41126RD. LUCA.
HOGENOMiHOG000113712.
HOVERGENiHBG052562.
InParanoidiQ7TNY7.
PhylomeDBiQ7TNY7.

Miscellaneous databases

PROiQ7TNY7.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006788. Myrip/Melanophilin.
IPR010911. Rab_BD.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02318. FYVE_2. 1 hit.
PF04698. Rab_eff_C. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYRIP_RAT
AccessioniPrimary (citable) accession number: Q7TNY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.