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Q7TNY6 (GCP60_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Golgi resident protein GCP60
Alternative name(s):
Acyl-CoA-binding domain-containing protein 3
DMT1-associated protein
Short name=DAP
Golgi complex-associated protein 1
Short name=GOCAP1
Golgi phosphoprotein 1
Short name=GOLPH1
Gene names
Name:Acbd3
Synonyms:Gcp60
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells By similarity.

Subunit structure

Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1. Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha By similarity.

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Mitochondrion By similarity. Note: Also mitochondrial (via its interaction with PBR) By similarity.

Domain

The GOLD domain is essential for giantin binding By similarity.

Sequence similarities

Contains 1 ACB (acyl-CoA-binding) domain.

Contains 1 GOLD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 526525Golgi resident protein GCP60
PRO_0000214031

Regions

Domain80 – 17192ACB
Domain381 – 524144GOLD
Coiled coil169 – 25486 Potential
Coiled coil450 – 47122 Potential
Compositional bias179 – 1846Poly-Glu
Compositional bias186 – 23550Arg-rich
Compositional bias238 – 30568Gln-rich

Amino acid modifications

Modified residue131Phosphoserine By similarity
Modified residue201Phosphoserine By similarity
Modified residue401Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TNY6 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FB1147D95DA48B45

FASTA52660,479
        10         20         30         40         50         60 
MAAQLNVEQL EVSLDGLTLS PDSEERPGAE GAPLQTPPSS PPRDGLGSGT AGQQREPGEA 

        70         80         90        100        110        120 
AAEGAAEEAR RMEQHWGFGL EELYGLALRF YKIKDGKAFH PTYEEKLKFV ALHKQVLLGP 

       130        140        150        160        170        180 
YNPDTSPEVG FFDVLGNDRR REWAALGNMS KEDAMVEFVK LLNKCCPLLS AYVASHRIEK 

       190        200        210        220        230        240 
EEEEKRRKAE EERRQREEEE RERLQKEEEK RKREEEDRLR REEEERRRIE EERLRLEQQK 

       250        260        270        280        290        300 
QQIMAALNSQ TAVQFQQYAA QQYPGNYEQQ QILIRQLQEQ HYQQYMQQLY QVQLAQQQAA 

       310        320        330        340        350        360 
LQKQQEVVVA GASLPASTKV NTAGASDPLP VNGQAKTHTE NPEKVLEPEA AEEALENGPK 

       370        380        390        400        410        420 
DSLPVIAAPS MWTRPQIKDF KEKIRQDADS VITVRRGEVV TVRVPTHEEG SYLFWEFATD 

       430        440        450        460        470        480 
SYDIGFGVYF EWTDSPNAAV SVHVSESSDD EEEEEEENVT CEEKAKKNVN KPLLDEIVPV 

       490        500        510        520 
YRRDCHEEVY AGSHQYPGRG VYLLKFDNSY SLWRSKSVYY RVYYTR

« Hide

References

[1]"Intestinal iron absorption: the interaction of DMT1 with DAP, an iron responsive protein."
Chen Y., Rodriguez-Paris J.M., Ma Y., Yeh M., Yeh K.-Y., Glass J.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Brown Norway.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY336075 mRNA. Translation: AAP94639.1.
IPIIPI00339079.
RefSeqNP_878263.1. NM_182843.1.
UniGeneRn.57036.

3D structure databases

ProteinModelPortalQ7TNY6.
ModBaseSearch...

PTM databases

PhosphoSiteQ7TNY6.

Proteomic databases

PaxDbQ7TNY6.
PRIDEQ7TNY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID289312.
KEGGrno:289312.
UCSCRGD:727851. rat.

Organism-specific databases

CTD64746.
RGD727851. Acbd3.

Phylogenomic databases

eggNOGNOG287879.
HOGENOMHOG000247039.
HOVERGENHBG051712.
InParanoidQ7TNY6.
OrthoDBEOG4WH8M8.

Gene expression databases

GenevestigatorQ7TNY6.
GermOnlineENSRNOG00000003185. Rattus norvegicus.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
InterProIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR009038. GOLD.
[Graphical view]
PfamPF00887. ACBP. 1 hit.
PF13897. GOLD_2. 1 hit.
[Graphical view]
SUPFAMSSF47027. ACBP. 1 hit.
SSF101576. GOLD. 1 hit.
PROSITEPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio629601.

Entry information

Entry nameGCP60_RAT
AccessionPrimary (citable) accession number: Q7TNY6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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