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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Gene

Tnfaip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis (By similarity). May enhance the PCNA-dependent DNA polymerase delta activity.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • cell migration Source: UniProtKB
  • DNA repair Source: UniProtKB
  • DNA replication Source: UniProtKB
  • immune response Source: UniProtKB
  • negative regulation of Rho protein signal transduction Source: UniProtKB
  • positive regulation of DNA replication Source: RGD
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • protein heterooligomerization Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
  • protein ubiquitination Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • stress fiber assembly Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Alternative name(s):
BTB/POZ domain-containing protein TNFAIP1
Tumor necrosis factor-induced protein 1
Gene namesi
Name:Tnfaip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3877 Tnfaip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312491 – 316BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278PhosphoserineBy similarity1
Modified residuei280Phosphoserine; by CK2By similarity1

Post-translational modificationi

Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TNY1
PRIDEiQ7TNY1

PTM databases

iPTMnetiQ7TNY1
PhosphoSitePlusiQ7TNY1

Expressioni

Gene expression databases

BgeeiENSRNOG00000009069
GenevisibleiQ7TNY1 RN

Interactioni

Subunit structurei

Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with CSNK2B (By similarity). Interacts with PCNA.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi252226, 1 interactor
STRINGi10116.ENSRNOP00000012245

Structurei

3D structure databases

ProteinModelPortaliQ7TNY1
SMRiQ7TNY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 96BTBAdd BLAST69

Sequence similaritiesi

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGiKOG2716 Eukaryota
ENOG410XQYZ LUCA
GeneTreeiENSGT00900000140932
HOVERGENiHBG052219
InParanoidiQ7TNY1
KOiK15074
OMAiREMSGDT
OrthoDBiEOG091G0L1Y
PhylomeDBiQ7TNY1
TreeFamiTF315649

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TNY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDTCLCPA SGAKPKISGF KGGGLGNKYV QLNVGGSLHY TTVRALTRHD
60 70 80 90 100
TMLKAMFSGR MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TVTLPQSRQE
110 120 130 140 150
IQELMAEAKY YLIQGLVSLC QAALQDKKDS YQPVCNIPII TSLREEDRLI
160 170 180 190 200
ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL KNIELFDKLS LRFNGRVLFI
210 220 230 240 250
KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE FPEARIYEET
260 270 280 290 300
LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEDTFELRD RVRRIHVKRY
310
STYDDRQLGH QSAHRD
Length:316
Mass (Da):36,046
Last modified:October 1, 2003 - v1
Checksum:i9F55209382D736E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336949 mRNA Translation: AAP97077.1
BC128704 mRNA Translation: AAI28705.1
RefSeqiNP_891995.1, NM_182950.4
UniGeneiRn.18199

Genome annotation databases

EnsembliENSRNOT00000012245; ENSRNOP00000012245; ENSRNOG00000009069
GeneIDi287543
KEGGirno:287543

Similar proteinsi

Entry informationi

Entry nameiBACD2_RAT
AccessioniPrimary (citable) accession number: Q7TNY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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