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Q7TNV9 (DFB14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 14

Short name=BD-14
Short name=mBD-14
Alternative name(s):
Defensin, beta 14
Gene names
Name:Defb14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length67 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 6745Beta-defensin 14
PRO_0000006942

Amino acid modifications

Disulfide bond33 ↔ 62 By similarity
Disulfide bond40 ↔ 55 By similarity
Disulfide bond45 ↔ 63 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TNV9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EEFF0D93ADF17452

FASTA677,718
        10         20         30         40         50         60 
MRLHYLLFVF LILFLVPAPG DAFLPKTLRK FFCRIRGGRC AVLNCLGKEE QIGRCSNSGR 


KCCRKKK 

« Hide

References

« Hide 'large scale' references
[1]"Amino acid residues subject to positive selection in murine b-defensin antimicrobial peptides."
Maxwell A., Dorin J.R.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ578468 mRNA. Translation: CAE17665.2.
BC116199 mRNA. Translation: AAI16200.1.
RefSeqNP_898847.1. NM_183026.2.
XP_006508855.1. XM_006508792.1.
XP_006508856.1. XM_006508793.1.
XP_006508857.1. XM_006508794.1.
XP_006508858.1. XM_006508795.1.
XP_006508859.1. XM_006508796.1.
XP_006508860.1. XM_006508797.1.
UniGeneMm.358923.

3D structure databases

ProteinModelPortalQ7TNV9.
SMRQ7TNV9. Positions 27-67.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB1.C.85.1.4. the pore-forming -defensin (-defensin) family.

Proteomic databases

PRIDEQ7TNV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052601; ENSMUSP00000062781; ENSMUSG00000046354.
GeneID244332.
KEGGmmu:244332.
UCSCuc009lai.2. mouse.

Organism-specific databases

CTD244332.
MGIMGI:2675345. Defb14.

Phylogenomic databases

eggNOGNOG40430.
GeneTreeENSGT00530000064280.
HOGENOMHOG000015465.
HOVERGENHBG004834.
InParanoidQ7TNV9.
OMASCLPREE.
OrthoDBEOG7SJD7S.
PhylomeDBQ7TNV9.

Gene expression databases

BgeeQ7TNV9.
CleanExMM_DEFB14.
GenevestigatorQ7TNV9.

Family and domain databases

InterProIPR001855. Defensin_beta-typ.
[Graphical view]
PfamPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386229.
PROQ7TNV9.
SOURCESearch...

Entry information

Entry nameDFB14_MOUSE
AccessionPrimary (citable) accession number: Q7TNV9
Secondary accession number(s): Q14BD1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot