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Q7TNV9

- DFB14_MOUSE

UniProt

Q7TNV9 - DFB14_MOUSE

Protein

Beta-defensin 14

Gene

Defb14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.By similarity

    GO - Molecular functioni

    1. chemoattractant activity Source: MGI

    GO - Biological processi

    1. cell chemotaxis Source: MGI
    2. defense response to bacterium Source: MGI
    3. positive chemotaxis Source: GOC

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_199048. Beta defensins.
    REACT_199049. Defensins.

    Protein family/group databases

    TCDBi1.C.85.1.4. the pore-forming -defensin (-defensin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 14
    Short name:
    BD-14
    Short name:
    mBD-14
    Alternative name(s):
    Defensin, beta 14
    Gene namesi
    Name:Defb14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2675345. Defb14.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 6745Beta-defensin 14PRO_0000006942Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 62By similarity
    Disulfide bondi40 ↔ 55By similarity
    Disulfide bondi45 ↔ 63By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ7TNV9.

    Expressioni

    Gene expression databases

    BgeeiQ7TNV9.
    CleanExiMM_DEFB14.
    GenevestigatoriQ7TNV9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TNV9.
    SMRiQ7TNV9. Positions 27-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40430.
    GeneTreeiENSGT00530000064280.
    HOGENOMiHOG000015465.
    HOVERGENiHBG004834.
    InParanoidiQ7TNV9.
    OMAiESICPLT.
    OrthoDBiEOG7SJD7S.
    PhylomeDBiQ7TNV9.

    Family and domain databases

    InterProiIPR001855. Defensin_beta-typ.
    [Graphical view]
    PfamiPF00711. Defensin_beta. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7TNV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLHYLLFVF LILFLVPAPG DAFLPKTLRK FFCRIRGGRC AVLNCLGKEE   50
    QIGRCSNSGR KCCRKKK 67
    Length:67
    Mass (Da):7,718
    Last modified:October 1, 2003 - v1
    Checksum:iEEFF0D93ADF17452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ578468 mRNA. Translation: CAE17665.2.
    BC116199 mRNA. Translation: AAI16200.1.
    CCDSiCCDS40253.1.
    RefSeqiNP_898847.1. NM_183026.2.
    XP_006508855.1. XM_006508792.1.
    XP_006508856.1. XM_006508793.1.
    XP_006508857.1. XM_006508794.1.
    XP_006508858.1. XM_006508795.1.
    XP_006508859.1. XM_006508796.1.
    XP_006508860.1. XM_006508797.1.
    UniGeneiMm.358923.

    Genome annotation databases

    EnsembliENSMUST00000052601; ENSMUSP00000062781; ENSMUSG00000046354.
    GeneIDi244332.
    KEGGimmu:244332.
    UCSCiuc009lai.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ578468 mRNA. Translation: CAE17665.2 .
    BC116199 mRNA. Translation: AAI16200.1 .
    CCDSi CCDS40253.1.
    RefSeqi NP_898847.1. NM_183026.2.
    XP_006508855.1. XM_006508792.1.
    XP_006508856.1. XM_006508793.1.
    XP_006508857.1. XM_006508794.1.
    XP_006508858.1. XM_006508795.1.
    XP_006508859.1. XM_006508796.1.
    XP_006508860.1. XM_006508797.1.
    UniGenei Mm.358923.

    3D structure databases

    ProteinModelPortali Q7TNV9.
    SMRi Q7TNV9. Positions 27-67.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.C.85.1.4. the pore-forming -defensin (-defensin) family.

    Proteomic databases

    PRIDEi Q7TNV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052601 ; ENSMUSP00000062781 ; ENSMUSG00000046354 .
    GeneIDi 244332.
    KEGGi mmu:244332.
    UCSCi uc009lai.2. mouse.

    Organism-specific databases

    CTDi 244332.
    MGIi MGI:2675345. Defb14.

    Phylogenomic databases

    eggNOGi NOG40430.
    GeneTreei ENSGT00530000064280.
    HOGENOMi HOG000015465.
    HOVERGENi HBG004834.
    InParanoidi Q7TNV9.
    OMAi ESICPLT.
    OrthoDBi EOG7SJD7S.
    PhylomeDBi Q7TNV9.

    Enzyme and pathway databases

    Reactomei REACT_199048. Beta defensins.
    REACT_199049. Defensins.

    Miscellaneous databases

    NextBioi 386229.
    PROi Q7TNV9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TNV9.
    CleanExi MM_DEFB14.
    Genevestigatori Q7TNV9.

    Family and domain databases

    InterProi IPR001855. Defensin_beta-typ.
    [Graphical view ]
    Pfami PF00711. Defensin_beta. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid residues subject to positive selection in murine b-defensin antimicrobial peptides."
      Maxwell A., Dorin J.R.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiDFB14_MOUSE
    AccessioniPrimary (citable) accession number: Q7TNV9
    Secondary accession number(s): Q14BD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3