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Q7TNV9

- DFB14_MOUSE

UniProt

Q7TNV9 - DFB14_MOUSE

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Protein

Beta-defensin 14

Gene

Defb14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.By similarity

GO - Molecular functioni

  1. chemoattractant activity Source: MGI

GO - Biological processi

  1. cell chemotaxis Source: MGI
  2. defense response to bacterium Source: MGI
  3. positive chemotaxis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_199048. Beta defensins.
REACT_199049. Defensins.

Protein family/group databases

TCDBi1.C.85.1.4. the pore-forming -defensin (-defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 14
Short name:
BD-14
Short name:
mBD-14
Alternative name(s):
Defensin, beta 14
Gene namesi
Name:Defb14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2675345. Defb14.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 6745Beta-defensin 14PRO_0000006942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 62By similarity
Disulfide bondi40 ↔ 55By similarity
Disulfide bondi45 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ7TNV9.

Expressioni

Gene expression databases

BgeeiQ7TNV9.
CleanExiMM_DEFB14.
GenevestigatoriQ7TNV9.

Structurei

3D structure databases

ProteinModelPortaliQ7TNV9.
SMRiQ7TNV9. Positions 27-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40430.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ7TNV9.
OMAiESICPLT.
OrthoDBiEOG7SJD7S.
PhylomeDBiQ7TNV9.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLHYLLFVF LILFLVPAPG DAFLPKTLRK FFCRIRGGRC AVLNCLGKEE
60
QIGRCSNSGR KCCRKKK
Length:67
Mass (Da):7,718
Last modified:October 1, 2003 - v1
Checksum:iEEFF0D93ADF17452
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ578468 mRNA. Translation: CAE17665.2.
BC116199 mRNA. Translation: AAI16200.1.
CCDSiCCDS40253.1.
RefSeqiNP_898847.1. NM_183026.2.
XP_006508855.1. XM_006508792.1.
XP_006508856.1. XM_006508793.1.
XP_006508857.1. XM_006508794.1.
XP_006508858.1. XM_006508795.1.
XP_006508859.1. XM_006508796.1.
XP_006508860.1. XM_006508797.1.
UniGeneiMm.358923.

Genome annotation databases

EnsembliENSMUST00000052601; ENSMUSP00000062781; ENSMUSG00000046354.
GeneIDi244332.
KEGGimmu:244332.
UCSCiuc009lai.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ578468 mRNA. Translation: CAE17665.2 .
BC116199 mRNA. Translation: AAI16200.1 .
CCDSi CCDS40253.1.
RefSeqi NP_898847.1. NM_183026.2.
XP_006508855.1. XM_006508792.1.
XP_006508856.1. XM_006508793.1.
XP_006508857.1. XM_006508794.1.
XP_006508858.1. XM_006508795.1.
XP_006508859.1. XM_006508796.1.
XP_006508860.1. XM_006508797.1.
UniGenei Mm.358923.

3D structure databases

ProteinModelPortali Q7TNV9.
SMRi Q7TNV9. Positions 27-67.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 1.C.85.1.4. the pore-forming -defensin (-defensin) family.

Proteomic databases

PRIDEi Q7TNV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052601 ; ENSMUSP00000062781 ; ENSMUSG00000046354 .
GeneIDi 244332.
KEGGi mmu:244332.
UCSCi uc009lai.2. mouse.

Organism-specific databases

CTDi 244332.
MGIi MGI:2675345. Defb14.

Phylogenomic databases

eggNOGi NOG40430.
GeneTreei ENSGT00530000064280.
HOGENOMi HOG000015465.
HOVERGENi HBG004834.
InParanoidi Q7TNV9.
OMAi ESICPLT.
OrthoDBi EOG7SJD7S.
PhylomeDBi Q7TNV9.

Enzyme and pathway databases

Reactomei REACT_199048. Beta defensins.
REACT_199049. Defensins.

Miscellaneous databases

NextBioi 386229.
PROi Q7TNV9.
SOURCEi Search...

Gene expression databases

Bgeei Q7TNV9.
CleanExi MM_DEFB14.
Genevestigatori Q7TNV9.

Family and domain databases

InterProi IPR001855. Defensin_beta-typ.
[Graphical view ]
Pfami PF00711. Defensin_beta. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Amino acid residues subject to positive selection in murine b-defensin antimicrobial peptides."
    Maxwell A., Dorin J.R.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDFB14_MOUSE
AccessioniPrimary (citable) accession number: Q7TNV9
Secondary accession number(s): Q14BD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3