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Protein

Beta-defensin 38

Gene

Defb38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Synthetic Defb38 kills both Gram-negative (E.coli and P.aeruginosa) and Gram-positive (E.faecium) bacteria.1 Publication

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 38
Short name:
BD-38
Short name:
mBD-38
Alternative name(s):
Defensin, beta 38
Gene namesi
Name:Defb38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2672972. Defb38.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000695022 – 63Beta-defensin 38Add BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 58By similarity
Disulfide bondi36 ↔ 51By similarity
Disulfide bondi41 ↔ 59By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7TNV7.
PRIDEiQ7TNV7.

Expressioni

Tissue specificityi

Only expressed in epididymis (caput, corpus and cauda).1 Publication

Gene expression databases

BgeeiENSMUSG00000053790.
CleanExiMM_DEFB38.
ExpressionAtlasiQ7TNV7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067553.

Structurei

3D structure databases

ProteinModelPortaliQ7TNV7.
SMRiQ7TNV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00900000141571.
HOGENOMiHOG000112188.
HOVERGENiHBG080892.
InParanoidiQ7TNV7.
OMAiYFECPWL.
OrthoDBiEOG091G18L0.
PhylomeDBiQ7TNV7.

Family and domain databases

InterProiView protein in InterPro
IPR001855. Defensin_beta-typ.
PfamiView protein in Pfam
PF00711. Defensin_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISCFLLLI LSLYFFQINQ AIGPDTKKCV QRKNACHYFE CPWLYYSVGT
60
CYKGKGKCCQ KRY
Length:63
Mass (Da):7,443
Last modified:October 1, 2003 - v1
Checksum:i56C7FCF84834B282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ575424 mRNA. Translation: CAE01397.1.
AJ578471 mRNA. Translation: CAE17668.1.
CCDSiCCDS40248.1.
RefSeqiNP_898857.1. NM_183036.1.
UniGeneiMm.271558.

Genome annotation databases

EnsembliENSMUST00000066416; ENSMUSP00000067553; ENSMUSG00000053790.
GeneIDi360212.
KEGGimmu:360212.
UCSCiuc009laa.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDFB38_MOUSE
AccessioniPrimary (citable) accession number: Q7TNV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families