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Protein

Protein DEK

Gene

Dek

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chromatin organization.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi342 – 356By similarityAdd BLAST15
DNA bindingi372 – 376By similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEK
Gene namesi
Name:Dek
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1926209. Dek.

Subcellular locationi

GO - Cellular componenti

  • contractile fiber Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798591 – 380Protein DEKAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineBy similarity1
Modified residuei33PhosphoserineCombined sources1
Modified residuei55PhosphoserineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei214PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei294PhosphothreonineBy similarity1
Modified residuei295PhosphothreonineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei308PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TNV0.
MaxQBiQ7TNV0.
PaxDbiQ7TNV0.
PeptideAtlasiQ7TNV0.
PRIDEiQ7TNV0.

PTM databases

iPTMnetiQ7TNV0.
PhosphoSitePlusiQ7TNV0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021377.
CleanExiMM_DEK.
ExpressionAtlasiQ7TNV0. baseline and differential.
GenevisibleiQ7TNV0. MM.

Interactioni

Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225256. 1 interactor.
IntActiQ7TNV0. 2 interactors.
MINTiMINT-1868135.
STRINGi10090.ENSMUSP00000021807.

Structurei

3D structure databases

ProteinModelPortaliQ7TNV0.
SMRiQ7TNV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 187SAPAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi209 – 225Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 53Asp/Glu-rich (highly acidic)Add BLAST23
Compositional biasi232 – 240Asp/Glu-rich (acidic)9
Compositional biasi245 – 258Asp/Glu-rich (acidic)Add BLAST14
Compositional biasi305 – 315Asp/Glu-rich (acidic)Add BLAST11

Sequence similaritiesi

Contains 1 SAP domain.Curated

Phylogenomic databases

eggNOGiKOG2266. Eukaryota.
ENOG410XTJA. LUCA.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiQ7TNV0.
KOiK17046.
OMAiNDPHEED.
OrthoDBiEOG091G0UKX.
PhylomeDBiQ7TNV0.
TreeFamiTF324696.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAAPAAE GEDAPVPPSS EKEPEMPGPR EESEEEEEDD EDDDEEDEEE
60 70 80 90 100
EKEKSLIVEG KREKKKVERL TMQVSSLQRE PFTVTQGKGQ KLCEIERIHF
110 120 130 140 150
FLSKKKPDEL RNLHKLLYNR PGTVSSLKKN VGQFSGFPFE KGSTQYKKKE
160 170 180 190 200
EMLKKFRNAM LKSICEVLDL ERSGVNSELV KRILNFLMHP KPSGKPLPKS
210 220 230 240 250
KKSSSKGSKK ERNSSGTTRK SKQTKCPEIL SDESSSDEDE KKNKEESSED
260 270 280 290 300
EEKESEEEQP PKKTSKKEKA KQKATAKSKK SVKSANVKKA DSSTTKKNQK
310 320 330 340 350
SSKKESESED SSDDEPLIKK LKKPPTDEEL KETVKKLLAD ANLEEVTMKQ
360 370 380
ICKEVYENYP AYDLTERKDF IKTTVKELIS
Length:380
Mass (Da):43,159
Last modified:October 1, 2003 - v1
Checksum:iCE1F01CA16CE5AC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97R → S in AAH48844 (PubMed:15489334).Curated1
Sequence conflicti362Y → C in BAC28296 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033451 mRNA. Translation: BAC28296.1.
BC048844 mRNA. Translation: AAH48844.1.
BC055451 mRNA. Translation: AAH55451.1.
CCDSiCCDS26490.1.
RefSeqiNP_080176.2. NM_025900.2.
UniGeneiMm.131150.

Genome annotation databases

EnsembliENSMUST00000021807; ENSMUSP00000021807; ENSMUSG00000021377.
GeneIDi110052.
KEGGimmu:110052.
UCSCiuc007qhw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033451 mRNA. Translation: BAC28296.1.
BC048844 mRNA. Translation: AAH48844.1.
BC055451 mRNA. Translation: AAH55451.1.
CCDSiCCDS26490.1.
RefSeqiNP_080176.2. NM_025900.2.
UniGeneiMm.131150.

3D structure databases

ProteinModelPortaliQ7TNV0.
SMRiQ7TNV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225256. 1 interactor.
IntActiQ7TNV0. 2 interactors.
MINTiMINT-1868135.
STRINGi10090.ENSMUSP00000021807.

PTM databases

iPTMnetiQ7TNV0.
PhosphoSitePlusiQ7TNV0.

Proteomic databases

EPDiQ7TNV0.
MaxQBiQ7TNV0.
PaxDbiQ7TNV0.
PeptideAtlasiQ7TNV0.
PRIDEiQ7TNV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021807; ENSMUSP00000021807; ENSMUSG00000021377.
GeneIDi110052.
KEGGimmu:110052.
UCSCiuc007qhw.2. mouse.

Organism-specific databases

CTDi7913.
MGIiMGI:1926209. Dek.

Phylogenomic databases

eggNOGiKOG2266. Eukaryota.
ENOG410XTJA. LUCA.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiQ7TNV0.
KOiK17046.
OMAiNDPHEED.
OrthoDBiEOG091G0UKX.
PhylomeDBiQ7TNV0.
TreeFamiTF324696.

Enzyme and pathway databases

ReactomeiR-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.

Miscellaneous databases

ChiTaRSiDek. mouse.
PROiQ7TNV0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021377.
CleanExiMM_DEK.
ExpressionAtlasiQ7TNV0. baseline and differential.
GenevisibleiQ7TNV0. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEK_MOUSE
AccessioniPrimary (citable) accession number: Q7TNV0
Secondary accession number(s): Q80VC5, Q8BZV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.