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Q7TNV0

- DEK_MOUSE

UniProt

Q7TNV0 - DEK_MOUSE

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Protein
Protein DEK
Gene
Dek
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in chromatin organization.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi342 – 35615 By similarity
Add
BLAST
DNA bindingi372 – 3765 By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. regulation of double-strand break repair via nonhomologous end joining Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEK
Gene namesi
Name:Dek
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1926209. Dek.

Subcellular locationi

Nucleus
Note: Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei By similarity.1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Protein DEK
PRO_0000079859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphoserine By similarity
Modified residuei33 – 331Phosphoserine1 Publication
Modified residuei55 – 551Phosphoserine1 Publication
Modified residuei163 – 1631Phosphoserine By similarity
Modified residuei205 – 2051Phosphoserine By similarity
Modified residuei208 – 2081Phosphoserine By similarity
Modified residuei214 – 2141Phosphoserine By similarity
Modified residuei231 – 2311Phosphoserine By similarity
Modified residuei234 – 2341Phosphoserine By similarity
Modified residuei235 – 2351Phosphoserine By similarity
Modified residuei236 – 2361Phosphoserine By similarity
Modified residuei247 – 2471Phosphoserine By similarity
Modified residuei248 – 2481Phosphoserine By similarity
Modified residuei255 – 2551Phosphoserine By similarity
Modified residuei292 – 2921Phosphoserine By similarity
Modified residuei293 – 2931Phosphoserine By similarity
Modified residuei294 – 2941Phosphothreonine By similarity
Modified residuei295 – 2951Phosphothreonine By similarity
Modified residuei301 – 3011Phosphoserine By similarity
Modified residuei306 – 3061Phosphoserine By similarity
Modified residuei308 – 3081Phosphoserine By similarity
Modified residuei311 – 3111Phosphoserine By similarity
Modified residuei312 – 3121Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TNV0.
PaxDbiQ7TNV0.
PRIDEiQ7TNV0.

PTM databases

PhosphoSiteiQ7TNV0.

Expressioni

Gene expression databases

ArrayExpressiQ7TNV0.
BgeeiQ7TNV0.
CleanExiMM_DEK.
GenevestigatoriQ7TNV0.

Interactioni

Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA By similarity.

Protein-protein interaction databases

BioGridi225256. 1 interaction.
IntActiQ7TNV0. 1 interaction.
MINTiMINT-1868135.
STRINGi10090.ENSMUSP00000021807.

Structurei

3D structure databases

ProteinModelPortaliQ7TNV0.
SMRiQ7TNV0. Positions 82-191, 314-380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 18735SAP
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi209 – 22517Nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 5323Asp/Glu-rich (highly acidic)
Add
BLAST
Compositional biasi232 – 2409Asp/Glu-rich (acidic)
Compositional biasi245 – 25814Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi305 – 31511Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Contains 1 SAP domain.

Phylogenomic databases

eggNOGiNOG328552.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiQ7TNV0.
KOiK17046.
OMAiNDPHEED.
OrthoDBiEOG7TF7C2.
PhylomeDBiQ7TNV0.
TreeFamiTF324696.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNV0-1 [UniParc]FASTAAdd to Basket

« Hide

MSAAAAPAAE GEDAPVPPSS EKEPEMPGPR EESEEEEEDD EDDDEEDEEE    50
EKEKSLIVEG KREKKKVERL TMQVSSLQRE PFTVTQGKGQ KLCEIERIHF 100
FLSKKKPDEL RNLHKLLYNR PGTVSSLKKN VGQFSGFPFE KGSTQYKKKE 150
EMLKKFRNAM LKSICEVLDL ERSGVNSELV KRILNFLMHP KPSGKPLPKS 200
KKSSSKGSKK ERNSSGTTRK SKQTKCPEIL SDESSSDEDE KKNKEESSED 250
EEKESEEEQP PKKTSKKEKA KQKATAKSKK SVKSANVKKA DSSTTKKNQK 300
SSKKESESED SSDDEPLIKK LKKPPTDEEL KETVKKLLAD ANLEEVTMKQ 350
ICKEVYENYP AYDLTERKDF IKTTVKELIS 380
Length:380
Mass (Da):43,159
Last modified:October 1, 2003 - v1
Checksum:iCE1F01CA16CE5AC1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971R → S in AAH48844. 1 Publication
Sequence conflicti362 – 3621Y → C in BAC28296. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK033451 mRNA. Translation: BAC28296.1.
BC048844 mRNA. Translation: AAH48844.1.
BC055451 mRNA. Translation: AAH55451.1.
CCDSiCCDS26490.1.
RefSeqiNP_080176.2. NM_025900.2.
UniGeneiMm.131150.

Genome annotation databases

EnsembliENSMUST00000021807; ENSMUSP00000021807; ENSMUSG00000021377.
GeneIDi110052.
KEGGimmu:110052.
UCSCiuc007qhw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK033451 mRNA. Translation: BAC28296.1 .
BC048844 mRNA. Translation: AAH48844.1 .
BC055451 mRNA. Translation: AAH55451.1 .
CCDSi CCDS26490.1.
RefSeqi NP_080176.2. NM_025900.2.
UniGenei Mm.131150.

3D structure databases

ProteinModelPortali Q7TNV0.
SMRi Q7TNV0. Positions 82-191, 314-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 225256. 1 interaction.
IntActi Q7TNV0. 1 interaction.
MINTi MINT-1868135.
STRINGi 10090.ENSMUSP00000021807.

PTM databases

PhosphoSitei Q7TNV0.

Proteomic databases

MaxQBi Q7TNV0.
PaxDbi Q7TNV0.
PRIDEi Q7TNV0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021807 ; ENSMUSP00000021807 ; ENSMUSG00000021377 .
GeneIDi 110052.
KEGGi mmu:110052.
UCSCi uc007qhw.2. mouse.

Organism-specific databases

CTDi 7913.
MGIi MGI:1926209. Dek.

Phylogenomic databases

eggNOGi NOG328552.
GeneTreei ENSGT00390000017282.
HOGENOMi HOG000059552.
HOVERGENi HBG004944.
InParanoidi Q7TNV0.
KOi K17046.
OMAi NDPHEED.
OrthoDBi EOG7TF7C2.
PhylomeDBi Q7TNV0.
TreeFami TF324696.

Miscellaneous databases

ChiTaRSi DEK. mouse.
NextBioi 363227.
PROi Q7TNV0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7TNV0.
Bgeei Q7TNV0.
CleanExi MM_DEK.
Genevestigatori Q7TNV0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view ]
Pfami PF08766. DEK_C. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view ]
SMARTi SM00513. SAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland and Salivary gland.
  3. "The distribution of the DEK protein in mammalian chromatin."
    Hu H.G., Scholten I., Gruss C., Knippers R.
    Biochem. Biophys. Res. Commun. 358:1008-1014(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33 AND SER-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDEK_MOUSE
AccessioniPrimary (citable) accession number: Q7TNV0
Secondary accession number(s): Q80VC5, Q8BZV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi