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Protein

Acid-sensing ion channel 4

Gene

Asic4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cation channel with high affinity for sodium.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 4
Short name:
ASIC4
Alternative name(s):
Amiloride-sensitive cation channel 4
Gene namesi
Name:Asic4
Synonyms:Accn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2652846. Asic4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 438349ExtracellularSequence analysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence analysisAdd
BLAST
Topological domaini460 – 53980CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Acid-sensing ion channel 4PRO_0000181305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi118 ↔ 202By similarity
Disulfide bondi180 ↔ 187By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi296 ↔ 375By similarity
Disulfide bondi318 ↔ 371By similarity
Disulfide bondi322 ↔ 369By similarity
Disulfide bondi331 ↔ 353By similarity
Disulfide bondi333 ↔ 345By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TNS7.
PaxDbiQ7TNS7.
PRIDEiQ7TNS7.

PTM databases

iPTMnetiQ7TNS7.
PhosphoSiteiQ7TNS7.

Expressioni

Gene expression databases

BgeeiQ7TNS7.
CleanExiMM_ACCN4.
ExpressionAtlasiQ7TNS7. baseline and differential.
GenevisibleiQ7TNS7. MM.

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045598.

Structurei

3D structure databases

ProteinModelPortaliQ7TNS7.
SMRiQ7TNS7. Positions 65-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000247010.
HOVERGENiHBG004150.
InParanoidiQ7TNS7.
KOiK04831.
OMAiNCRAESG.
PhylomeDBiQ7TNS7.
TreeFamiTF330663.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIEIVCKIK FAEEDAKPKE KEAGDEQSLL GAAQGPAAPR DLATFASTST
60 70 80 90 100
LHGLGRACGP GPHGLRRTLW ALALLTSLAA FLYQAASLAR GYLTRPHLVA
110 120 130 140 150
MDPAAPAPVA GFPAVTLCNI NRFRHSALSD ADIFHLANLT GLPPKDRDGH
160 170 180 190 200
RAAGLRYPEP DMVDILNRTG HQLADMLKSC NFSGHHCSAS NFSVVYTRYG
210 220 230 240 250
KCYTFNADPQ SSLPSRAGGM GSGLEIMLDI QQEEYLPIWR ETNETSFEAG
260 270 280 290 300
IRVQIHSQEE PPYIHQLGFG VSPGFQTFVS CQEQRLTYLP QPWGNCRAES
310 320 330 340 350
ELREPELQGY SAYSVSACRL RCEKEAVLQR CHCRMVHMPG NETICPPNIY
360 370 380 390 400
IECADHTLDS LGGGSEGPCF CPTPCNLTRY GKEISMVKIP NRGSARYLAR
410 420 430 440 450
KYNRNETYIR ENFLVLDVFF EALTSEAMEQ QAAYGLSALL GDLGGQMGLF
460 470 480 490 500
IGASILTLLE ILDYIYEVSW DRLKRVWRRP KTPLRTSTGG ISTLGLQELK
510 520 530
EQSPCPSRGR AEGGGASSLL PNHHHPHGPP GSLFEDFAC
Length:539
Mass (Da):59,216
Last modified:October 1, 2003 - v1
Checksum:i25A4B1E73D67FE9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046481 mRNA. Translation: AAH46481.1.
BC055772 mRNA. Translation: AAH55772.1.
CCDSiCCDS15073.1.
RefSeqiNP_898843.1. NM_183022.3.
UniGeneiMm.110790.

Genome annotation databases

EnsembliENSMUST00000037708; ENSMUSP00000045598; ENSMUSG00000033007.
GeneIDi241118.
KEGGimmu:241118.
UCSCiuc007bpg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046481 mRNA. Translation: AAH46481.1.
BC055772 mRNA. Translation: AAH55772.1.
CCDSiCCDS15073.1.
RefSeqiNP_898843.1. NM_183022.3.
UniGeneiMm.110790.

3D structure databases

ProteinModelPortaliQ7TNS7.
SMRiQ7TNS7. Positions 65-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045598.

PTM databases

iPTMnetiQ7TNS7.
PhosphoSiteiQ7TNS7.

Proteomic databases

MaxQBiQ7TNS7.
PaxDbiQ7TNS7.
PRIDEiQ7TNS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037708; ENSMUSP00000045598; ENSMUSG00000033007.
GeneIDi241118.
KEGGimmu:241118.
UCSCiuc007bpg.1. mouse.

Organism-specific databases

CTDi55515.
MGIiMGI:2652846. Asic4.

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000247010.
HOVERGENiHBG004150.
InParanoidiQ7TNS7.
KOiK04831.
OMAiNCRAESG.
PhylomeDBiQ7TNS7.
TreeFamiTF330663.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Miscellaneous databases

PROiQ7TNS7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TNS7.
CleanExiMM_ACCN4.
ExpressionAtlasiQ7TNS7. baseline and differential.
GenevisibleiQ7TNS7. MM.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiASIC4_MOUSE
AccessioniPrimary (citable) accession number: Q7TNS7
Secondary accession number(s): Q80XK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vitro, has no proton-gated channel activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.