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Protein

Immunoglobulin superfamily member 21

Gene

Igsf21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.1 Publication

GO - Biological processi

  • synapse maturation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 21
Short name:
IgSF21
Gene namesi
Name:Igsf21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2681842 Igsf21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutants grow normally. They show an impaired sensorimotor gating with no effect on motor activity and coordination.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000022333925 – 468Immunoglobulin superfamily member 21Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 116PROSITE-ProRule annotation
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ7TNR6
PaxDbiQ7TNR6
PeptideAtlasiQ7TNR6
PRIDEiQ7TNR6

PTM databases

PhosphoSitePlusiQ7TNR6

Expressioni

Tissue specificityi

Expressed in brain (at protein levels) (PubMed:28864826). Highly expressed in the pyramidal cell layer of the dorsal and ventral hippocampal CA1 and CA3 regions, layers 5 and 6 of the cortex, the thalamus and the pons and weakly expressed in the cerebellum (PubMed:28864826). Expressed in neurons but not in glia (PubMed:28864826).1 Publication

Developmental stagei

Expressed in the brain at both embryonic and postnatal stages including the adult stage. The period of highest expression of the long isoform is at around two postnatal weeks, coinciding with the peak period of synaptogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000040972
CleanExiMM_IGSF21
GenevisibleiQ7TNR6 MM

Interactioni

Subunit structurei

Interacts (Ig-like 1 domain) with NRXN2 (via Laminin G-like 1 domain) in a trans-interaction manner.1 Publication

Protein-protein interaction databases

IntActiQ7TNR6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ7TNR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 132Ig-like 1Add BLAST108
Domaini344 – 429Ig-like 2Add BLAST86

Domaini

Ig-like 1 domain is indispensable for synaptogenic activity whereas Ig-like 2 domain is secondarily responsible for the activity.1 Publication

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFDU Eukaryota
ENOG410XPIE LUCA
GeneTreeiENSGT00390000002421
HOGENOMiHOG000261657
HOVERGENiHBG061499
InParanoidiQ7TNR6
OMAiFLTVMSP
OrthoDBiEOG091G096X
PhylomeDBiQ7TNR6
TreeFamiTF331223

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAAPSLRRA SCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT
60 70 80 90 100
DGRMREIVWY RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST
110 120 130 140 150
VRLPEVRISD NGPYECHVGI YDRATREKVV LASGNIFLNV MAPPTSIEVV
160 170 180 190 200
AADSPAPFSR YQAQNFTLVC IVSGGKPAPM VYFKRDGEPI DAVPLTELPA
210 220 230 240 250
ASSGPVQDSR PFRSLLHRDV DDTKMQKSLS LLDTEYRAGR PYTERPARSL
260 270 280 290 300
TQDPSLFVQP TTENIPETVV SREFPRWVHS AEPVYFLRHS RTPGSDGTVE
310 320 330 340 350
VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIMMTP
360 370 380 390 400
SRARVGDTVR ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE
410 420 430 440 450
RVPAELNGSM YRCTAQNPLG STDTHTRLIV FENPNIPRGT EDSRGSASGP
460
AGVRLTLVLA LTVILELT
Length:468
Mass (Da):51,937
Last modified:October 1, 2003 - v1
Checksum:iB9577B5E9B66633D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055811 mRNA Translation: AAH55811.1
CCDSiCCDS18851.1
RefSeqiNP_941012.1, NM_198610.2
UniGeneiMm.298731

Genome annotation databases

EnsembliENSMUST00000039331; ENSMUSP00000046558; ENSMUSG00000040972
GeneIDi230868
KEGGimmu:230868
UCSCiuc008vmu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIGS21_MOUSE
AccessioniPrimary (citable) accession number: Q7TNR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health