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Q7TNP2

- 2AAB_MOUSE

UniProt

Q7TNP2 - 2AAB_MOUSE

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Protein
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Gene
Ppp2r1b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196577. MASTL Facilitates Mitotic Progression.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_203795. DARPP-32 events.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_207679. Separation of Sister Chromatids.
REACT_208887. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
REACT_210064. ERKs are inactivated.
REACT_215063. ERK/MAPK targets.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_217323. Integration of energy metabolism.
REACT_218396. Beta-catenin phosphorylation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Alternative name(s):
PP2A subunit A isoform PR65-beta
PP2A subunit A isoform R1-beta
Gene namesi
Name:Ppp2r1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1920949. Ppp2r1b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 601600Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
PRO_0000071404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7TNP2.
PaxDbiQ7TNP2.
PRIDEiQ7TNP2.

PTM databases

PhosphoSiteiQ7TNP2.

Expressioni

Gene expression databases

ArrayExpressiQ7TNP2.
BgeeiQ7TNP2.
GenevestigatoriQ7TNP2.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 By similarity. Interacts with SGOL1 By similarity. Interacts with RAF1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Unc5bQ8K1S32EBI-4396871,EBI-4396886

Protein-protein interaction databases

IntActiQ7TNP2. 1 interaction.
STRINGi10090.ENSMUSP00000034560.

Structurei

3D structure databases

ProteinModelPortaliQ7TNP2.
SMRiQ7TNP2. Positions 19-601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 5839HEAT 1
Add
BLAST
Repeati59 – 9638HEAT 2
Add
BLAST
Repeati97 – 13539HEAT 3
Add
BLAST
Repeati136 – 17338HEAT 4
Add
BLAST
Repeati174 – 21239HEAT 5
Add
BLAST
Repeati213 – 25139HEAT 6
Add
BLAST
Repeati252 – 29039HEAT 7
Add
BLAST
Repeati291 – 33343HEAT 8
Add
BLAST
Repeati334 – 37239HEAT 9
Add
BLAST
Repeati373 – 41139HEAT 10
Add
BLAST
Repeati412 – 45039HEAT 11
Add
BLAST
Repeati451 – 48939HEAT 12
Add
BLAST
Repeati490 – 52839HEAT 13
Add
BLAST
Repeati529 – 56739HEAT 14
Add
BLAST
Repeati568 – 60134HEAT 15
Add
BLAST

Domaini

Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.

Sequence similaritiesi

Contains 15 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG247268.
GeneTreeiENSGT00730000110944.
HOGENOMiHOG000078539.
HOVERGENiHBG000011.
KOiK03456.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
[Graphical view]
PfamiPF02985. HEAT. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNP2-1 [UniParc]FASTAAdd to Basket

« Hide

MAGAAGPGSG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI    50
ALALGVERTR TELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC 100
LLPPLESLAT VEETVVRDKA VESLRQISQE HTPVALEAHF VPLVKRLASG 150
DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ HFRSLCSDDT PMVRRAAASK 200
LGEFAKVLEL DSVKTEIVPL FTNLASDEQD SVRLLAVEAC VSIAQLLSQE 250
DLEALVMPTL RQAAEDKSWR VRYMVADKFS ELQKAVGPKI ALSDLIPAFQ 300
SLLRDCEAEV RAAAAHKVRE LCENLPAEGR ETVIMNQILP YIKELVSDTN 350
QHVKSALASV IMGLSTVLGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL 400
DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF 450
FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV 500
MANDPNYLHR MTTLFCINAL SEACGKEITT KQMLPIVLKM AGDQVANVRF 550
NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL 600
A 601
Length:601
Mass (Da):65,934
Last modified:July 27, 2011 - v2
Checksum:i801D903C90D1F15A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541T → M in AAH56218. 1 Publication
Sequence conflicti193 – 1931V → E in AAH56218. 1 Publication
Sequence conflicti257 – 2571M → I in AAH56218. 1 Publication
Sequence conflicti350 – 3501N → S in AAH56218. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC103406 Genomic DNA. No translation available.
AC123614 Genomic DNA. No translation available.
BC056218 mRNA. Translation: AAH56218.1.
CCDSiCCDS40626.1.
RefSeqiNP_082890.2. NM_028614.3.
UniGeneiMm.7726.

Genome annotation databases

EnsembliENSMUST00000114437; ENSMUSP00000110080; ENSMUSG00000032058.
GeneIDi73699.
KEGGimmu:73699.
UCSCiuc009pkv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC103406 Genomic DNA. No translation available.
AC123614 Genomic DNA. No translation available.
BC056218 mRNA. Translation: AAH56218.1 .
CCDSi CCDS40626.1.
RefSeqi NP_082890.2. NM_028614.3.
UniGenei Mm.7726.

3D structure databases

ProteinModelPortali Q7TNP2.
SMRi Q7TNP2. Positions 19-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7TNP2. 1 interaction.
STRINGi 10090.ENSMUSP00000034560.

PTM databases

PhosphoSitei Q7TNP2.

Proteomic databases

MaxQBi Q7TNP2.
PaxDbi Q7TNP2.
PRIDEi Q7TNP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114437 ; ENSMUSP00000110080 ; ENSMUSG00000032058 .
GeneIDi 73699.
KEGGi mmu:73699.
UCSCi uc009pkv.1. mouse.

Organism-specific databases

CTDi 5519.
MGIi MGI:1920949. Ppp2r1b.

Phylogenomic databases

eggNOGi NOG247268.
GeneTreei ENSGT00730000110944.
HOGENOMi HOG000078539.
HOVERGENi HBG000011.
KOi K03456.

Enzyme and pathway databases

Reactomei REACT_196577. MASTL Facilitates Mitotic Progression.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_203795. DARPP-32 events.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_207679. Separation of Sister Chromatids.
REACT_208887. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
REACT_210064. ERKs are inactivated.
REACT_215063. ERK/MAPK targets.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_217323. Integration of energy metabolism.
REACT_218396. Beta-catenin phosphorylation cascade.

Miscellaneous databases

NextBioi 338839.
PROi Q7TNP2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7TNP2.
Bgeei Q7TNP2.
Genevestigatori Q7TNP2.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
[Graphical view ]
Pfami PF02985. HEAT. 3 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50077. HEAT_REPEAT. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry namei2AAB_MOUSE
AccessioniPrimary (citable) accession number: Q7TNP2
Secondary accession number(s): E9QNJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi