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Q7TNP2

- 2AAB_MOUSE

UniProt

Q7TNP2 - 2AAB_MOUSE

Protein

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Gene

Ppp2r1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    ReactomeiREACT_196577. MASTL Facilitates Mitotic Progression.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_203795. DARPP-32 events.
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_207679. Separation of Sister Chromatids.
    REACT_208887. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
    REACT_210064. ERKs are inactivated.
    REACT_215063. ERK/MAPK targets.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_217323. Integration of energy metabolism.
    REACT_218396. Beta-catenin phosphorylation cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    Alternative name(s):
    PP2A subunit A isoform PR65-beta
    PP2A subunit A isoform R1-beta
    Gene namesi
    Name:Ppp2r1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1920949. Ppp2r1b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 601600Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPRO_0000071404Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ7TNP2.
    PaxDbiQ7TNP2.
    PRIDEiQ7TNP2.

    PTM databases

    PhosphoSiteiQ7TNP2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TNP2.
    BgeeiQ7TNP2.
    GenevestigatoriQ7TNP2.

    Interactioni

    Subunit structurei

    PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 By similarity. Interacts with SGOL1 By similarity. Interacts with RAF1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Unc5bQ8K1S32EBI-4396871,EBI-4396886

    Protein-protein interaction databases

    IntActiQ7TNP2. 1 interaction.
    STRINGi10090.ENSMUSP00000034560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TNP2.
    SMRiQ7TNP2. Positions 19-601.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati20 – 5839HEAT 1Add
    BLAST
    Repeati59 – 9638HEAT 2Add
    BLAST
    Repeati97 – 13539HEAT 3Add
    BLAST
    Repeati136 – 17338HEAT 4Add
    BLAST
    Repeati174 – 21239HEAT 5Add
    BLAST
    Repeati213 – 25139HEAT 6Add
    BLAST
    Repeati252 – 29039HEAT 7Add
    BLAST
    Repeati291 – 33343HEAT 8Add
    BLAST
    Repeati334 – 37239HEAT 9Add
    BLAST
    Repeati373 – 41139HEAT 10Add
    BLAST
    Repeati412 – 45039HEAT 11Add
    BLAST
    Repeati451 – 48939HEAT 12Add
    BLAST
    Repeati490 – 52839HEAT 13Add
    BLAST
    Repeati529 – 56739HEAT 14Add
    BLAST
    Repeati568 – 60134HEAT 15Add
    BLAST

    Domaini

    Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.

    Sequence similaritiesi

    Contains 15 HEAT repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG247268.
    GeneTreeiENSGT00730000110944.
    HOGENOMiHOG000078539.
    HOVERGENiHBG000011.
    KOiK03456.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    IPR021133. HEAT_type_2.
    [Graphical view]
    PfamiPF02985. HEAT. 3 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50077. HEAT_REPEAT. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7TNP2-1 [UniParc]FASTAAdd to Basket

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    MAGAAGPGSG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI    50
    ALALGVERTR TELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC 100
    LLPPLESLAT VEETVVRDKA VESLRQISQE HTPVALEAHF VPLVKRLASG 150
    DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ HFRSLCSDDT PMVRRAAASK 200
    LGEFAKVLEL DSVKTEIVPL FTNLASDEQD SVRLLAVEAC VSIAQLLSQE 250
    DLEALVMPTL RQAAEDKSWR VRYMVADKFS ELQKAVGPKI ALSDLIPAFQ 300
    SLLRDCEAEV RAAAAHKVRE LCENLPAEGR ETVIMNQILP YIKELVSDTN 350
    QHVKSALASV IMGLSTVLGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL 400
    DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF 450
    FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV 500
    MANDPNYLHR MTTLFCINAL SEACGKEITT KQMLPIVLKM AGDQVANVRF 550
    NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL 600
    A 601
    Length:601
    Mass (Da):65,934
    Last modified:July 27, 2011 - v2
    Checksum:i801D903C90D1F15A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541T → M in AAH56218. (PubMed:15489334)Curated
    Sequence conflicti193 – 1931V → E in AAH56218. (PubMed:15489334)Curated
    Sequence conflicti257 – 2571M → I in AAH56218. (PubMed:15489334)Curated
    Sequence conflicti350 – 3501N → S in AAH56218. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC103406 Genomic DNA. No translation available.
    AC123614 Genomic DNA. No translation available.
    BC056218 mRNA. Translation: AAH56218.1.
    CCDSiCCDS40626.1.
    RefSeqiNP_082890.2. NM_028614.3.
    UniGeneiMm.7726.

    Genome annotation databases

    EnsembliENSMUST00000114437; ENSMUSP00000110080; ENSMUSG00000032058.
    GeneIDi73699.
    KEGGimmu:73699.
    UCSCiuc009pkv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC103406 Genomic DNA. No translation available.
    AC123614 Genomic DNA. No translation available.
    BC056218 mRNA. Translation: AAH56218.1 .
    CCDSi CCDS40626.1.
    RefSeqi NP_082890.2. NM_028614.3.
    UniGenei Mm.7726.

    3D structure databases

    ProteinModelPortali Q7TNP2.
    SMRi Q7TNP2. Positions 19-601.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q7TNP2. 1 interaction.
    STRINGi 10090.ENSMUSP00000034560.

    PTM databases

    PhosphoSitei Q7TNP2.

    Proteomic databases

    MaxQBi Q7TNP2.
    PaxDbi Q7TNP2.
    PRIDEi Q7TNP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114437 ; ENSMUSP00000110080 ; ENSMUSG00000032058 .
    GeneIDi 73699.
    KEGGi mmu:73699.
    UCSCi uc009pkv.1. mouse.

    Organism-specific databases

    CTDi 5519.
    MGIi MGI:1920949. Ppp2r1b.

    Phylogenomic databases

    eggNOGi NOG247268.
    GeneTreei ENSGT00730000110944.
    HOGENOMi HOG000078539.
    HOVERGENi HBG000011.
    KOi K03456.

    Enzyme and pathway databases

    Reactomei REACT_196577. MASTL Facilitates Mitotic Progression.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_203795. DARPP-32 events.
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_207679. Separation of Sister Chromatids.
    REACT_208887. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
    REACT_210064. ERKs are inactivated.
    REACT_215063. ERK/MAPK targets.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_217323. Integration of energy metabolism.
    REACT_218396. Beta-catenin phosphorylation cascade.

    Miscellaneous databases

    NextBioi 338839.
    PROi Q7TNP2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TNP2.
    Bgeei Q7TNP2.
    Genevestigatori Q7TNP2.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    IPR021133. HEAT_type_2.
    [Graphical view ]
    Pfami PF02985. HEAT. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50077. HEAT_REPEAT. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry namei2AAB_MOUSE
    AccessioniPrimary (citable) accession number: Q7TNP2
    Secondary accession number(s): E9QNJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3