Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7TNP2 (2AAB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Alternative name(s):
PP2A subunit A isoform PR65-beta
PP2A subunit A isoform R1-beta
Gene names
Name:Ppp2r1b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit By similarity.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 By similarity. Interacts with SGOL1 By similarity. Interacts with RAF1 By similarity.

Domain

Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit A family.

Contains 15 HEAT repeats.

Ontologies

Keywords
   DomainRepeat
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction PubMed 21172653. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Unc5bQ8K1S32EBI-4396871,EBI-4396886

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 601600Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
PRO_0000071404

Regions

Repeat20 – 5839HEAT 1
Repeat59 – 9638HEAT 2
Repeat97 – 13539HEAT 3
Repeat136 – 17338HEAT 4
Repeat174 – 21239HEAT 5
Repeat213 – 25139HEAT 6
Repeat252 – 29039HEAT 7
Repeat291 – 33343HEAT 8
Repeat334 – 37239HEAT 9
Repeat373 – 41139HEAT 10
Repeat412 – 45039HEAT 11
Repeat451 – 48939HEAT 12
Repeat490 – 52839HEAT 13
Repeat529 – 56739HEAT 14
Repeat568 – 60134HEAT 15

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Experimental info

Sequence conflict1541T → M in AAH56218. Ref.2
Sequence conflict1931V → E in AAH56218. Ref.2
Sequence conflict2571M → I in AAH56218. Ref.2
Sequence conflict3501N → S in AAH56218. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7TNP2 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 801D903C90D1F15A

FASTA60165,934
        10         20         30         40         50         60 
MAGAAGPGSG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR 

        70         80         90        100        110        120 
TELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLESLAT VEETVVRDKA 

       130        140        150        160        170        180 
VESLRQISQE HTPVALEAHF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ 

       190        200        210        220        230        240 
HFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKTEIVPL FTNLASDEQD SVRLLAVEAC 

       250        260        270        280        290        300 
VSIAQLLSQE DLEALVMPTL RQAAEDKSWR VRYMVADKFS ELQKAVGPKI ALSDLIPAFQ 

       310        320        330        340        350        360 
SLLRDCEAEV RAAAAHKVRE LCENLPAEGR ETVIMNQILP YIKELVSDTN QHVKSALASV 

       370        380        390        400        410        420 
IMGLSTVLGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL DCVNEVIGIR QLSQSLLPAI 

       430        440        450        460        470        480 
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK 

       490        500        510        520        530        540 
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGKEITT KQMLPIVLKM 

       550        560        570        580        590        600 
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL 


A 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC103406 Genomic DNA. No translation available.
AC123614 Genomic DNA. No translation available.
BC056218 mRNA. Translation: AAH56218.1.
CCDSCCDS40626.1.
RefSeqNP_082890.2. NM_028614.3.
UniGeneMm.7726.

3D structure databases

ProteinModelPortalQ7TNP2.
SMRQ7TNP2. Positions 19-601.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ7TNP2. 1 interaction.
STRING10090.ENSMUSP00000034560.

PTM databases

PhosphoSiteQ7TNP2.

Proteomic databases

MaxQBQ7TNP2.
PaxDbQ7TNP2.
PRIDEQ7TNP2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114437; ENSMUSP00000110080; ENSMUSG00000032058.
GeneID73699.
KEGGmmu:73699.
UCSCuc009pkv.1. mouse.

Organism-specific databases

CTD5519.
MGIMGI:1920949. Ppp2r1b.

Phylogenomic databases

eggNOGNOG247268.
GeneTreeENSGT00730000110944.
HOGENOMHOG000078539.
HOVERGENHBG000011.
KOK03456.

Gene expression databases

ArrayExpressQ7TNP2.
BgeeQ7TNP2.
GenevestigatorQ7TNP2.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
[Graphical view]
PfamPF02985. HEAT. 3 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50077. HEAT_REPEAT. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio338839.
PROQ7TNP2.
SOURCESearch...

Entry information

Entry name2AAB_MOUSE
AccessionPrimary (citable) accession number: Q7TNP2
Secondary accession number(s): E9QNJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot