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Protein

Ammonium transporter Rh type C

Gene

Rhcg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity).By similarity

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: UniProtKB
  • ankyrin binding Source: UniProtKB

GO - Biological processi

  • ammonium transport Source: UniProtKB
  • cellular ion homeostasis Source: UniProtKB
  • transepithelial ammonium transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Gene namesi
Name:Rhcg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727859. Rhcg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 6131ExtracellularSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 9311CytoplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 12511ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 14520HelicalSequence analysisAdd
BLAST
Topological domaini146 – 1516CytoplasmicSequence analysis
Transmembranei152 – 17423HelicalSequence analysisAdd
BLAST
Topological domaini175 – 1795ExtracellularSequence analysis
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Topological domaini201 – 21919CytoplasmicSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Topological domaini241 – 25111ExtracellularSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 28210CytoplasmicSequence analysis
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Topological domaini304 – 3041ExtracellularSequence analysis
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 34015CytoplasmicSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 39534ExtracellularSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Topological domaini417 – 49781CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: RGD
  • basolateral plasma membrane Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Ammonium transporter Rh type CPRO_0000283584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TNN9.

Expressioni

Tissue specificityi

Expressed by connecting tubule cells and intercalated cells of the collecting duct in kidney (at protein level).1 Publication

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021109.

Structurei

3D structure databases

ProteinModelPortaliQ7TNN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ7TNN9.
KOiK06580.
PhylomeDBiQ7TNN9.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TNN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWNTNLRGR LPITCLILQV TMVVLFGVFV RYDIQADAHW WLEKKRKNIS
60 70 80 90 100
SDVENEFYYR YPSFEDVHAM VFVGFGFLMT YLQRYGFSAV GFNFLLAAFG
110 120 130 140 150
IQWALLMQGW FHFFEEGHIL LSVENLIQAD FCVASTCVAF GAVLGKISPM
160 170 180 190 200
QLLIMTFFQV TLFTVNEFIL LNLIEAKDAG GSMTIHTFGA YFGLTVTWIL
210 220 230 240 250
YRKNLEQSKQ RQSSVYHSDL FAMIGTLFLW IYWPSFNSAS SFHGDTQHRA
260 270 280 290 300
ALNTYLSLAA SVLTTVAVSS VIHKKGKLDM VHIQNATLAG GVGVGTAAEM
310 320 330 340 350
MLTPYGALIV GFFCGILSTL GFAYLSPFLE SRLRIQDTCG IHNLHGIPGI
360 370 380 390 400
IGGIVGAVTA AYSSPDVYGE PGIVHSFGFG GYKADWTKRM QGRSQIFGLL
410 420 430 440 450
LSLAMALVGG IIVGFILKLP FWGQASDENC FEDAIYWEVP EEVNTVYIPE
460 470 480 490
DLAHKHSTSL VPAIPLVLST PSASIVPPVP PTPPASLATV TSSSLVH
Length:497
Mass (Da):54,731
Last modified:October 1, 2003 - v1
Checksum:iC696D975833F3B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129073 mRNA. Translation: AAN07791.1.
RefSeqiNP_898876.1. NM_183053.1.
UniGeneiRn.18789.

Genome annotation databases

GeneIDi293048.
KEGGirno:293048.
UCSCiRGD:727859. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129073 mRNA. Translation: AAN07791.1.
RefSeqiNP_898876.1. NM_183053.1.
UniGeneiRn.18789.

3D structure databases

ProteinModelPortaliQ7TNN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021109.

Proteomic databases

PaxDbiQ7TNN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi293048.
KEGGirno:293048.
UCSCiRGD:727859. rat.

Organism-specific databases

CTDi51458.
RGDi727859. Rhcg.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ7TNN9.
KOiK06580.
PhylomeDBiQ7TNN9.

Miscellaneous databases

PROiQ7TNN9.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolutionary conservation and diversification of Rh family genes and proteins."
    Huang C.-H., Peng J.
    Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter, along the rat nephron."
    Eladari D., Cheval L., Quentin F., Bertrand O., Mouro I., Cherif-Zahar B., Cartron J.-P., Paillard M., Doucet A., Chambrey R.
    J. Am. Soc. Nephrol. 13:1999-2008(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron."
    Quentin F., Eladari D., Cheval L., Lopez C., Goossens D., Colin Y., Cartron J.-P., Paillard M., Chambrey R.
    J. Am. Soc. Nephrol. 14:545-554(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis."
    Seshadri R.M., Klein J.D., Smith T., Sands J.M., Handlogten M.E., Verlander J.W., Weiner I.D.
    Am. J. Physiol. 290:F1443-F1452(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRHCG_RAT
AccessioniPrimary (citable) accession number: Q7TNN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.