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Protein

Ammonium transporter Rh type C

Gene

Rhcg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity).By similarity

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: UniProtKB
  • ankyrin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAmmonia transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Gene namesi
Name:Rhcg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi727859 Rhcg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 61ExtracellularSequence analysisAdd BLAST31
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 93CytoplasmicSequence analysisAdd BLAST11
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 125ExtracellularSequence analysisAdd BLAST11
Transmembranei126 – 145HelicalSequence analysisAdd BLAST20
Topological domaini146 – 151CytoplasmicSequence analysis6
Transmembranei152 – 174HelicalSequence analysisAdd BLAST23
Topological domaini175 – 179ExtracellularSequence analysis5
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 219CytoplasmicSequence analysisAdd BLAST19
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 251ExtracellularSequence analysisAdd BLAST11
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 282CytoplasmicSequence analysis10
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304ExtracellularSequence analysis1
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 340CytoplasmicSequence analysisAdd BLAST15
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 395ExtracellularSequence analysisAdd BLAST34
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 497CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835841 – 497Ammonium transporter Rh type CAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TNN9
PRIDEiQ7TNN9

Expressioni

Tissue specificityi

Expressed by connecting tubule cells and intercalated cells of the collecting duct in kidney (at protein level).1 Publication

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021109

Structurei

3D structure databases

ProteinModelPortaliQ7TNN9
SMRiQ7TNN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796 Eukaryota
ENOG410XTF8 LUCA
HOGENOMiHOG000007656
HOVERGENiHBG004374
InParanoidiQ7TNN9
KOiK06580
PhylomeDBiQ7TNN9

Family and domain databases

Gene3Di1.10.3430.10, 1 hit
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD
PfamiView protein in Pfam
PF00909 Ammonium_transp, 1 hit
PRINTSiPR00342 RHESUSRHD

Sequencei

Sequence statusi: Complete.

Q7TNN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWNTNLRGR LPITCLILQV TMVVLFGVFV RYDIQADAHW WLEKKRKNIS
60 70 80 90 100
SDVENEFYYR YPSFEDVHAM VFVGFGFLMT YLQRYGFSAV GFNFLLAAFG
110 120 130 140 150
IQWALLMQGW FHFFEEGHIL LSVENLIQAD FCVASTCVAF GAVLGKISPM
160 170 180 190 200
QLLIMTFFQV TLFTVNEFIL LNLIEAKDAG GSMTIHTFGA YFGLTVTWIL
210 220 230 240 250
YRKNLEQSKQ RQSSVYHSDL FAMIGTLFLW IYWPSFNSAS SFHGDTQHRA
260 270 280 290 300
ALNTYLSLAA SVLTTVAVSS VIHKKGKLDM VHIQNATLAG GVGVGTAAEM
310 320 330 340 350
MLTPYGALIV GFFCGILSTL GFAYLSPFLE SRLRIQDTCG IHNLHGIPGI
360 370 380 390 400
IGGIVGAVTA AYSSPDVYGE PGIVHSFGFG GYKADWTKRM QGRSQIFGLL
410 420 430 440 450
LSLAMALVGG IIVGFILKLP FWGQASDENC FEDAIYWEVP EEVNTVYIPE
460 470 480 490
DLAHKHSTSL VPAIPLVLST PSASIVPPVP PTPPASLATV TSSSLVH
Length:497
Mass (Da):54,731
Last modified:October 1, 2003 - v1
Checksum:iC696D975833F3B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129073 mRNA Translation: AAN07791.1
RefSeqiNP_898876.1, NM_183053.1
UniGeneiRn.18789

Genome annotation databases

GeneIDi293048
KEGGirno:293048
UCSCiRGD:727859 rat

Similar proteinsi

Entry informationi

Entry nameiRHCG_RAT
AccessioniPrimary (citable) accession number: Q7TNN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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