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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

Cox8c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene namesi
Name:Cox8c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi727840. Cox8c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 40Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei41 – 64HelicalBy similarityAdd BLAST24
Topological domaini65 – 72Mitochondrial intermembraneBy similarity8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000000620230 – 72Cytochrome c oxidase subunit 8C, mitochondrialAdd BLAST43

Proteomic databases

PaxDbiQ7TNN2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031106.

Structurei

3D structure databases

ProteinModelPortaliQ7TNN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000012036.
HOGENOMiHOG000111895.
InParanoidiQ7TNN2.
KOiK02273.
OMAiHSESPQN.
OrthoDBiEOG091G1A16.
PhylomeDBiQ7TNN2.
TreeFamiTF105070.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLQFCSS LLRHRVVLFS KPGHSGRLSH SESPQNQVLT PTESVVGIVV
60 70
FFATFFIPAA YVMSNLKFFK GE
Length:72
Mass (Da):8,073
Last modified:October 1, 2003 - v1
Checksum:i298553EED9F236EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161005 mRNA. Translation: AAO26194.1.
RefSeqiNP_898878.1. NM_183055.1.
UniGeneiRn.98192.

Genome annotation databases

EnsembliENSRNOT00000052296; ENSRNOP00000047295; ENSRNOG00000031106.
GeneIDi360229.
KEGGirno:360229.
UCSCiRGD:727840. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161005 mRNA. Translation: AAO26194.1.
RefSeqiNP_898878.1. NM_183055.1.
UniGeneiRn.98192.

3D structure databases

ProteinModelPortaliQ7TNN2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ7TNN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000052296; ENSRNOP00000047295; ENSRNOG00000031106.
GeneIDi360229.
KEGGirno:360229.
UCSCiRGD:727840. rat.

Organism-specific databases

CTDi341947.
RGDi727840. Cox8c.

Phylogenomic databases

GeneTreeiENSGT00390000012036.
HOGENOMiHOG000111895.
InParanoidiQ7TNN2.
KOiK02273.
OMAiHSESPQN.
OrthoDBiEOG091G1A16.
PhylomeDBiQ7TNN2.
TreeFamiTF105070.

Miscellaneous databases

PROiQ7TNN2.

Gene expression databases

BgeeiENSRNOG00000031106.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8C_RAT
AccessioniPrimary (citable) accession number: Q7TNN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.