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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

Cox8c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene namesi
Name:Cox8c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi727840 Cox8c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 40Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei41 – 64HelicalBy similarityAdd BLAST24
Topological domaini65 – 72Mitochondrial intermembraneBy similarity8

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000000620230 – 72Cytochrome c oxidase subunit 8C, mitochondrialAdd BLAST43

Proteomic databases

PaxDbiQ7TNN2

Expressioni

Gene expression databases

BgeeiENSRNOG00000031106

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047295

Structurei

3D structure databases

ProteinModelPortaliQ7TNN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000012036
HOGENOMiHOG000111895
InParanoidiQ7TNN2
KOiK02273
OMAiHSESPQN
OrthoDBiEOG091G1A16
PhylomeDBiQ7TNN2
TreeFamiTF105070

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLQFCSS LLRHRVVLFS KPGHSGRLSH SESPQNQVLT PTESVVGIVV
60 70
FFATFFIPAA YVMSNLKFFK GE
Length:72
Mass (Da):8,073
Last modified:October 1, 2003 - v1
Checksum:i298553EED9F236EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161005 mRNA Translation: AAO26194.1
RefSeqiNP_898878.1, NM_183055.1
UniGeneiRn.98192

Genome annotation databases

EnsembliENSRNOT00000052296; ENSRNOP00000047295; ENSRNOG00000031106
GeneIDi360229
KEGGirno:360229
UCSCiRGD:727840 rat

Similar proteinsi

Entry informationi

Entry nameiCOX8C_RAT
AccessioniPrimary (citable) accession number: Q7TNN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health