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Protein
Submitted name:

Dual specificity phosphatase 9

Gene

Dusp9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • kinase activity Source: UniProtKB-KW
  • MAP kinase tyrosine/serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  • inactivation of MAPK activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-112409. RAF-independent MAPK1/3 activation.
R-MMU-5675221. Negative regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Dual specificity phosphatase 9Imported
Submitted name:
Dual specificity phosphatase 9, isoform CRA_aImported
Submitted name:
Dual-specificity MAP kinase phosphatase-4Imported
Submitted name:
Protein Dusp9Imported
Gene namesi
Name:Dusp9Imported
ORF Names:mCG_3242Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2387107. Dusp9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ7TNL7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031383.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019701.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 207190RhodaneseInterPro annotationAdd
BLAST
Domaini271 – 413143Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini335 – 39561TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili119 – 16749Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1717. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000294079.
HOVERGENiHBG007347.
KOiK18498.
OMAiYLMQKRH.
OrthoDBiEOG091G0249.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLSRSCLW LRQELSSPRP QLLLLDCRSR ELYESARICG ALSVALPSLM
60 70 80 90 100
LRRLRRGSMS VRSLLPGPPL QPPPPAPVLL YDQGSSGQCH REAAEAEAKA
110 120 130 140 150
EPKAEAEAEP KAEAEAEPKA EAENEAEAKA EAKAEAKAEA KAEAKAEAKA
160 170 180 190 200
EAKAEAKAEA KAEAKEEWDA DSVLGVLLQK LREEGYPAYY LQGGFSKFQA
210 220 230 240 250
ECPHLCETSF SGRAGSGLGS MSSPVPVVGL GGLCLSSDFS DAESEADRDT
260 270 280 290 300
LSCGLDSENT TSPPAGLLPP FPVQILPNLY LGSARDSANL ESLAKLGIRY
310 320 330 340 350
ILNVTPNLPN LFEKNGDFHY KQIPISDHWS QNLSQFFPEA IAFIDEALSQ
360 370 380 390 400
NCGVLVHCLA GVSRSVTVTV AYLMQKLHLS LNDAYDLVKR KKSNISPNFN
410 420 430 440 450
FMGQLLDFER SLRLGGKRSG GRGSGGPEST VSDPPSFFTT PTSDGVFELD

PT
Length:452
Mass (Da):48,658
Last modified:October 1, 2003 - v1
Checksum:iDDC700B64233020F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805924 Genomic DNA. No translation available.
BC100309 mRNA. Translation: AAI00310.1.
AY316312 mRNA. Translation: AAP81160.1.
CH466650 Genomic DNA. Translation: EDL29892.1.
RefSeqiNP_083628.3. NM_029352.3.
UniGeneiMm.16479.

Genome annotation databases

EnsembliENSMUST00000019701; ENSMUSP00000019701; ENSMUSG00000031383.
GeneIDi75590.
KEGGimmu:75590.
UCSCiuc009tmb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805924 Genomic DNA. No translation available.
BC100309 mRNA. Translation: AAI00310.1.
AY316312 mRNA. Translation: AAP81160.1.
CH466650 Genomic DNA. Translation: EDL29892.1.
RefSeqiNP_083628.3. NM_029352.3.
UniGeneiMm.16479.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019701.

PTM databases

PhosphoSiteiQ7TNL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019701; ENSMUSP00000019701; ENSMUSG00000031383.
GeneIDi75590.
KEGGimmu:75590.
UCSCiuc009tmb.1. mouse.

Organism-specific databases

CTDi1852.
MGIiMGI:2387107. Dusp9.

Phylogenomic databases

eggNOGiKOG1717. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000294079.
HOVERGENiHBG007347.
KOiK18498.
OMAiYLMQKRH.
OrthoDBiEOG091G0249.
TreeFamiTF105122.

Enzyme and pathway databases

ReactomeiR-MMU-112409. RAF-independent MAPK1/3 activation.
R-MMU-5675221. Negative regulation of MAPK pathway.

Miscellaneous databases

ChiTaRSiDusp9. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031383.

Family and domain databases

Gene3Di3.40.250.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TNL7_MOUSE
AccessioniPrimary (citable) accession number: Q7TNL7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.