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Protein

Serine/threonine-protein kinase 40

Gene

Stk40

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661ATPPROSITE-ProRule annotation
Active sitei197 – 1971Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 499ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 40 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase lyk4
Gene namesi
Name:Stk40
Synonyms:Lyk4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727884. Stk40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Serine/threonine-protein kinase 40PRO_0000252264Add
BLAST

Proteomic databases

PaxDbiQ7TNL4.

PTM databases

PhosphoSiteiQ7TNL4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032827.

Structurei

3D structure databases

ProteinModelPortaliQ7TNL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 332298Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000007322.
HOVERGENiHBG080296.
InParanoidiQ7TNL4.
KOiK16312.
OrthoDBiEOG7W1543.
PhylomeDBiQ7TNL4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF16. PTHR22961:SF16. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRASDRGA GETSAKAQAL GTGIAGNNAK RAGPFILGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL
210 220 230 240 250
GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP
410 420 430
KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK
Length:435
Mass (Da):48,960
Last modified:October 1, 2003 - v1
Checksum:i8D2AA03152CE5211
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti397 – 3971A → T in AAI00063 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336055 mRNA. Translation: AAQ01589.1.
BC100062 mRNA. Translation: AAI00063.1.
RefSeqiNP_898879.2. NM_183056.2.
XP_006238943.1. XM_006238881.2.
UniGeneiRn.4052.

Genome annotation databases

GeneIDi360230.
KEGGirno:360230.
UCSCiRGD:727884. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336055 mRNA. Translation: AAQ01589.1.
BC100062 mRNA. Translation: AAI00063.1.
RefSeqiNP_898879.2. NM_183056.2.
XP_006238943.1. XM_006238881.2.
UniGeneiRn.4052.

3D structure databases

ProteinModelPortaliQ7TNL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032827.

PTM databases

PhosphoSiteiQ7TNL4.

Proteomic databases

PaxDbiQ7TNL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360230.
KEGGirno:360230.
UCSCiRGD:727884. rat.

Organism-specific databases

CTDi83931.
RGDi727884. Stk40.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000007322.
HOVERGENiHBG080296.
InParanoidiQ7TNL4.
KOiK16312.
OrthoDBiEOG7W1543.
PhylomeDBiQ7TNL4.

Miscellaneous databases

NextBioi672740.
PROiQ7TNL4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF16. PTHR22961:SF16. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human, mouse, rat, chick and frog lyk4 gene."
    Shan Y.X., Yu L.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSTK40_RAT
AccessioniPrimary (citable) accession number: Q7TNL4
Secondary accession number(s): Q498V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.