Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase 40

Gene

Stk40

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66ATPPROSITE-ProRule annotation1
Active sitei197Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 49ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 40 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase lyk4
Gene namesi
Name:Stk40
Synonyms:Lyk4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727884 Stk40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522641 – 435Serine/threonine-protein kinase 40Add BLAST435

Proteomic databases

PaxDbiQ7TNL4

PTM databases

PhosphoSitePlusiQ7TNL4

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032827

Structurei

3D structure databases

ProteinModelPortaliQ7TNL4
SMRiQ7TNL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 332Protein kinasePROSITE-ProRule annotationAdd BLAST298

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
HOGENOMiHOG000007322
HOVERGENiHBG080296
InParanoidiQ7TNL4
KOiK16312
PhylomeDBiQ7TNL4

Family and domain databases

CDDicd13974 STKc_SHIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR024236 Ser/Thr_kinase_40
IPR008271 Ser/Thr_kinase_AS
IPR024104 Tribbles/Ser_Thr_kinase_40
PANTHERiPTHR22961 PTHR22961, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TNL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRASDRGA GETSAKAQAL GTGIAGNNAK RAGPFILGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL
210 220 230 240 250
GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP
410 420 430
KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK
Length:435
Mass (Da):48,960
Last modified:October 1, 2003 - v1
Checksum:i8D2AA03152CE5211
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397A → T in AAI00063 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336055 mRNA Translation: AAQ01589.1
BC100062 mRNA Translation: AAI00063.1
RefSeqiNP_898879.2, NM_183056.2
XP_006238943.1, XM_006238881.3
UniGeneiRn.4052

Genome annotation databases

GeneIDi360230
KEGGirno:360230
UCSCiRGD:727884 rat

Similar proteinsi

Entry informationi

Entry nameiSTK40_RAT
AccessioniPrimary (citable) accession number: Q7TNL4
Secondary accession number(s): Q498V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome