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Protein

Serine/threonine-protein kinase 40

Gene

Stk40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661ATPPROSITE-ProRule annotation
Active sitei197 – 1971Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 499ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. glycogen metabolic process Source: MGI
  2. lung alveolus development Source: MGI
  3. lung development Source: MGI
  4. lung morphogenesis Source: MGI
  5. multicellular organism growth Source: MGI
  6. negative regulation of apoptotic process Source: MGI
  7. regulation of gene expression Source: MGI
  8. regulation of MAPK cascade Source: MGI
  9. respiratory system process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 40 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase lyk4
Gene namesi
Name:Stk40
Synonyms:Lyk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1921428. Stk40.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Serine/threonine-protein kinase 40PRO_0000252262Add
BLAST

Proteomic databases

PaxDbiQ7TNL3.
PRIDEiQ7TNL3.

PTM databases

PhosphoSiteiQ7TNL3.

Expressioni

Gene expression databases

BgeeiQ7TNL3.
CleanExiMM_STK40.
ExpressionAtlasiQ7TNL3. baseline and differential.
GenevestigatoriQ7TNL3.

Interactioni

Protein-protein interaction databases

DIPiDIP-58526N.
STRINGi10090.ENSMUSP00000111990.

Structurei

3D structure databases

ProteinModelPortaliQ7TNL3.
SMRiQ7TNL3. Positions 35-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 332298Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000007322.
HOVERGENiHBG080296.
InParanoidiQ7TNL3.
KOiK16312.
OMAiGNIPPVR.
OrthoDBiEOG7W1543.
PhylomeDBiQ7TNL3.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF1. PTHR22961:SF1. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7TNL3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRRASDRGA GETSANAKAL GTGIAGNNAK RAGPFVLGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL
210 220 230 240 250
GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP
410 420 430
KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK
Length:435
Mass (Da):48,932
Last modified:October 1, 2003 - v1
Checksum:i5AA58BA842CE2ACF
GO
Isoform 2 (identifier: Q7TNL3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKPYLRGASTQELRM

Note: No experimental confirmation available.

Show »
Length:449
Mass (Da):50,564
Checksum:iDA5D43BE556E7B92
GO

Sequence cautioni

The sequence AAH46981.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961R → L in BAB26110. (PubMed:16141072)Curated
Sequence conflicti392 – 3921I → V in BAB26110. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MKPYLRGASTQELRM in isoform 2. 1 PublicationVSP_020901

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336057 mRNA. Translation: AAQ01591.1.
AB102946 mRNA. Translation: BAC81568.1.
AK009154 mRNA. Translation: BAB26110.2.
AK050808 mRNA. Translation: BAC34419.2.
AK154780 mRNA. Translation: BAE32823.1.
AL731780 Genomic DNA. Translation: CAM22313.1.
BC046981 mRNA. Translation: AAH46981.1. Different initiation.
CCDSiCCDS51299.1. [Q7TNL3-2]
CCDS51300.1. [Q7TNL3-1]
RefSeqiNP_001139299.1. NM_001145827.1. [Q7TNL3-2]
NP_083076.3. NM_028800.3. [Q7TNL3-1]
XP_006503504.1. XM_006503441.1. [Q7TNL3-2]
XP_006503505.1. XM_006503442.1. [Q7TNL3-1]
UniGeneiMm.440269.

Genome annotation databases

EnsembliENSMUST00000094761; ENSMUSP00000092354; ENSMUSG00000042608. [Q7TNL3-1]
ENSMUST00000116286; ENSMUSP00000111990; ENSMUSG00000042608. [Q7TNL3-2]
GeneIDi74178.
KEGGimmu:74178.
UCSCiuc008usl.2. mouse. [Q7TNL3-1]
uc008usm.2. mouse. [Q7TNL3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336057 mRNA. Translation: AAQ01591.1.
AB102946 mRNA. Translation: BAC81568.1.
AK009154 mRNA. Translation: BAB26110.2.
AK050808 mRNA. Translation: BAC34419.2.
AK154780 mRNA. Translation: BAE32823.1.
AL731780 Genomic DNA. Translation: CAM22313.1.
BC046981 mRNA. Translation: AAH46981.1. Different initiation.
CCDSiCCDS51299.1. [Q7TNL3-2]
CCDS51300.1. [Q7TNL3-1]
RefSeqiNP_001139299.1. NM_001145827.1. [Q7TNL3-2]
NP_083076.3. NM_028800.3. [Q7TNL3-1]
XP_006503504.1. XM_006503441.1. [Q7TNL3-2]
XP_006503505.1. XM_006503442.1. [Q7TNL3-1]
UniGeneiMm.440269.

3D structure databases

ProteinModelPortaliQ7TNL3.
SMRiQ7TNL3. Positions 35-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58526N.
STRINGi10090.ENSMUSP00000111990.

PTM databases

PhosphoSiteiQ7TNL3.

Proteomic databases

PaxDbiQ7TNL3.
PRIDEiQ7TNL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094761; ENSMUSP00000092354; ENSMUSG00000042608. [Q7TNL3-1]
ENSMUST00000116286; ENSMUSP00000111990; ENSMUSG00000042608. [Q7TNL3-2]
GeneIDi74178.
KEGGimmu:74178.
UCSCiuc008usl.2. mouse. [Q7TNL3-1]
uc008usm.2. mouse. [Q7TNL3-2]

Organism-specific databases

CTDi83931.
MGIiMGI:1921428. Stk40.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000007322.
HOVERGENiHBG080296.
InParanoidiQ7TNL3.
KOiK16312.
OMAiGNIPPVR.
OrthoDBiEOG7W1543.
PhylomeDBiQ7TNL3.
TreeFamiTF329785.

Miscellaneous databases

ChiTaRSiStk40. mouse.
NextBioi340002.
PROiQ7TNL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TNL3.
CleanExiMM_STK40.
ExpressionAtlasiQ7TNL3. baseline and differential.
GenevestigatoriQ7TNL3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF1. PTHR22961:SF1. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human, mouse, rat, chick and frog lyk4 gene."
    Shan Y.X., Yu L.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system."
    Matsuki T., Hori G., Furuichi T.
    Brain Res. Mol. Brain Res. 136:231-254(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J, ICR and NOD.
    Tissue: Brain and Tongue.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiSTK40_MOUSE
AccessioniPrimary (citable) accession number: Q7TNL3
Secondary accession number(s): B1AW01
, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.