Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7TNL3 (STK40_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase 40

EC=2.7.11.1
Alternative name(s):
Serine/threonine-protein kinase lyk4
Gene names
Name:Stk40
Synonyms:Lyk4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH46981.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycogen metabolic process

Inferred from mutant phenotype PubMed 23293024. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 23043544. Source: MGI

lung development

Inferred from mutant phenotype PubMed 23043544. Source: MGI

lung morphogenesis

Inferred from mutant phenotype PubMed 23043544. Source: MGI

multicellular organism growth

Inferred from mutant phenotype PubMed 23293024. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 23043544. Source: MGI

regulation of MAPK cascade

Inferred from mutant phenotype PubMed 23043544. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 23043544. Source: MGI

respiratory system process

Inferred from mutant phenotype PubMed 23043544. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 23043544. Source: MGI

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7TNL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7TNL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKPYLRGASTQELRM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Serine/threonine-protein kinase 40
PRO_0000252262

Regions

Domain35 – 332298Protein kinase
Nucleotide binding41 – 499ATP By similarity

Sites

Active site1971Proton acceptor By similarity
Binding site661ATP By similarity

Natural variations

Alternative sequence11M → MKPYLRGASTQELRM in isoform 2.
VSP_020901

Experimental info

Sequence conflict1961R → L in BAB26110. Ref.3
Sequence conflict3921I → V in BAB26110. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5AA58BA842CE2ACF

FASTA43548,932
        10         20         30         40         50         60 
MKRRASDRGA GETSANAKAL GTGIAGNNAK RAGPFVLGPR LGNSPVPSIV QCLARKDGTD 

        70         80         90        100        110        120 
DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL HTQDGVVHHH GLFQDRTCEA 

       130        140        150        160        170        180 
VEDTESGRMV KKMKKRICLV LDCLCAHDFS DKTADLINLQ HYVIKEKRLS ERETVVIFYD 

       190        200        210        220        230        240 
VVRVVEALHQ KNIVHRDLKL GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI 

       250        260        270        280        290        300 
SPDVLSGRPY RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS 

       310        320        330        340        350        360 
ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD IDDQMSSSDS 

       370        380        390        400        410        420 
SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP KRQFGSMPPV RRLGHDAQPM 

       430 
TSLDTAILAQ RYLRK 

« Hide

Isoform 2 [UniParc].

Checksum: DA5D43BE556E7B92
Show »

FASTA44950,564

References

« Hide 'large scale' references
[1]"Cloning and characterization of human, mouse, rat, chick and frog lyk4 gene."
Shan Y.X., Yu L.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[2]"Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system."
Matsuki T., Hori G., Furuichi T.
Brain Res. Mol. Brain Res. 136:231-254(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J, ICR and NOD.
Tissue: Brain and Tongue.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY336057 mRNA. Translation: AAQ01591.1.
AB102946 mRNA. Translation: BAC81568.1.
AK009154 mRNA. Translation: BAB26110.2.
AK050808 mRNA. Translation: BAC34419.2.
AK154780 mRNA. Translation: BAE32823.1.
AL731780 Genomic DNA. Translation: CAM22313.1.
BC046981 mRNA. Translation: AAH46981.1. Different initiation.
CCDSCCDS51299.1. [Q7TNL3-2]
CCDS51300.1. [Q7TNL3-1]
RefSeqNP_001139299.1. NM_001145827.1. [Q7TNL3-2]
NP_083076.3. NM_028800.3. [Q7TNL3-1]
XP_006503504.1. XM_006503441.1. [Q7TNL3-2]
XP_006503505.1. XM_006503442.1. [Q7TNL3-1]
UniGeneMm.440269.

3D structure databases

ProteinModelPortalQ7TNL3.
SMRQ7TNL3. Positions 35-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-58526N.
STRING10090.ENSMUSP00000111990.

PTM databases

PhosphoSiteQ7TNL3.

Proteomic databases

PaxDbQ7TNL3.
PRIDEQ7TNL3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094761; ENSMUSP00000092354; ENSMUSG00000042608. [Q7TNL3-1]
ENSMUST00000116286; ENSMUSP00000111990; ENSMUSG00000042608. [Q7TNL3-2]
GeneID74178.
KEGGmmu:74178.
UCSCuc008usl.2. mouse. [Q7TNL3-1]
uc008usm.2. mouse. [Q7TNL3-2]

Organism-specific databases

CTD83931.
MGIMGI:1921428. Stk40.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000114880.
HOGENOMHOG000007322.
HOVERGENHBG080296.
InParanoidB1AW01.
KOK16312.
OMAGNIPPVR.
OrthoDBEOG7W1543.
PhylomeDBQ7TNL3.
TreeFamTF329785.

Gene expression databases

ArrayExpressQ7TNL3.
BgeeQ7TNL3.
CleanExMM_STK40.
GenevestigatorQ7TNL3.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF1. PTHR22961:SF1. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTK40. mouse.
NextBio340002.
PROQ7TNL3.
SOURCESearch...

Entry information

Entry nameSTK40_MOUSE
AccessionPrimary (citable) accession number: Q7TNL3
Secondary accession number(s): B1AW01 expand/collapse secondary AC list , Q3U3G3, Q811D6, Q8BKT1, Q9D7K3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot