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Q7TNL3

- STK40_MOUSE

UniProt

Q7TNL3 - STK40_MOUSE

Protein

Serine/threonine-protein kinase 40

Gene

Stk40

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661ATPPROSITE-ProRule annotation
    Active sitei197 – 1971Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 499ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glycogen metabolic process Source: MGI
    2. lung alveolus development Source: MGI
    3. lung development Source: MGI
    4. lung morphogenesis Source: MGI
    5. multicellular organism growth Source: MGI
    6. negative regulation of apoptotic process Source: MGI
    7. regulation of gene expression Source: MGI
    8. regulation of MAPK cascade Source: MGI
    9. respiratory system process Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 40 (EC:2.7.11.1)
    Alternative name(s):
    Serine/threonine-protein kinase lyk4
    Gene namesi
    Name:Stk40
    Synonyms:Lyk4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1921428. Stk40.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Serine/threonine-protein kinase 40PRO_0000252262Add
    BLAST

    Proteomic databases

    PaxDbiQ7TNL3.
    PRIDEiQ7TNL3.

    PTM databases

    PhosphoSiteiQ7TNL3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TNL3.
    BgeeiQ7TNL3.
    CleanExiMM_STK40.
    GenevestigatoriQ7TNL3.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-58526N.
    STRINGi10090.ENSMUSP00000111990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TNL3.
    SMRiQ7TNL3. Positions 35-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 332298Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114880.
    HOGENOMiHOG000007322.
    HOVERGENiHBG080296.
    InParanoidiB1AW01.
    KOiK16312.
    OMAiGNIPPVR.
    OrthoDBiEOG7W1543.
    PhylomeDBiQ7TNL3.
    TreeFamiTF329785.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024236. Ser/Thr_kinase_40.
    IPR008271. Ser/Thr_kinase_AS.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view]
    PANTHERiPTHR22961. PTHR22961. 1 hit.
    PTHR22961:SF1. PTHR22961:SF1. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TNL3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRRASDRGA GETSANAKAL GTGIAGNNAK RAGPFVLGPR LGNSPVPSIV    50
    QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL 100
    HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS 150
    DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL 200
    GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY 250
    RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS 300
    ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD 350
    IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP 400
    KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK 435
    Length:435
    Mass (Da):48,932
    Last modified:October 1, 2003 - v1
    Checksum:i5AA58BA842CE2ACF
    GO
    Isoform 2 (identifier: Q7TNL3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKPYLRGASTQELRM

    Note: No experimental confirmation available.

    Show »
    Length:449
    Mass (Da):50,564
    Checksum:iDA5D43BE556E7B92
    GO

    Sequence cautioni

    The sequence AAH46981.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961R → L in BAB26110. (PubMed:16141072)Curated
    Sequence conflicti392 – 3921I → V in BAB26110. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MKPYLRGASTQELRM in isoform 2. 1 PublicationVSP_020901

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY336057 mRNA. Translation: AAQ01591.1.
    AB102946 mRNA. Translation: BAC81568.1.
    AK009154 mRNA. Translation: BAB26110.2.
    AK050808 mRNA. Translation: BAC34419.2.
    AK154780 mRNA. Translation: BAE32823.1.
    AL731780 Genomic DNA. Translation: CAM22313.1.
    BC046981 mRNA. Translation: AAH46981.1. Different initiation.
    CCDSiCCDS51299.1. [Q7TNL3-2]
    CCDS51300.1. [Q7TNL3-1]
    RefSeqiNP_001139299.1. NM_001145827.1. [Q7TNL3-2]
    NP_083076.3. NM_028800.3. [Q7TNL3-1]
    XP_006503504.1. XM_006503441.1. [Q7TNL3-2]
    XP_006503505.1. XM_006503442.1. [Q7TNL3-1]
    UniGeneiMm.440269.

    Genome annotation databases

    EnsembliENSMUST00000094761; ENSMUSP00000092354; ENSMUSG00000042608. [Q7TNL3-1]
    ENSMUST00000116286; ENSMUSP00000111990; ENSMUSG00000042608. [Q7TNL3-2]
    GeneIDi74178.
    KEGGimmu:74178.
    UCSCiuc008usl.2. mouse. [Q7TNL3-1]
    uc008usm.2. mouse. [Q7TNL3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY336057 mRNA. Translation: AAQ01591.1 .
    AB102946 mRNA. Translation: BAC81568.1 .
    AK009154 mRNA. Translation: BAB26110.2 .
    AK050808 mRNA. Translation: BAC34419.2 .
    AK154780 mRNA. Translation: BAE32823.1 .
    AL731780 Genomic DNA. Translation: CAM22313.1 .
    BC046981 mRNA. Translation: AAH46981.1 . Different initiation.
    CCDSi CCDS51299.1. [Q7TNL3-2 ]
    CCDS51300.1. [Q7TNL3-1 ]
    RefSeqi NP_001139299.1. NM_001145827.1. [Q7TNL3-2 ]
    NP_083076.3. NM_028800.3. [Q7TNL3-1 ]
    XP_006503504.1. XM_006503441.1. [Q7TNL3-2 ]
    XP_006503505.1. XM_006503442.1. [Q7TNL3-1 ]
    UniGenei Mm.440269.

    3D structure databases

    ProteinModelPortali Q7TNL3.
    SMRi Q7TNL3. Positions 35-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-58526N.
    STRINGi 10090.ENSMUSP00000111990.

    PTM databases

    PhosphoSitei Q7TNL3.

    Proteomic databases

    PaxDbi Q7TNL3.
    PRIDEi Q7TNL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094761 ; ENSMUSP00000092354 ; ENSMUSG00000042608 . [Q7TNL3-1 ]
    ENSMUST00000116286 ; ENSMUSP00000111990 ; ENSMUSG00000042608 . [Q7TNL3-2 ]
    GeneIDi 74178.
    KEGGi mmu:74178.
    UCSCi uc008usl.2. mouse. [Q7TNL3-1 ]
    uc008usm.2. mouse. [Q7TNL3-2 ]

    Organism-specific databases

    CTDi 83931.
    MGIi MGI:1921428. Stk40.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114880.
    HOGENOMi HOG000007322.
    HOVERGENi HBG080296.
    InParanoidi B1AW01.
    KOi K16312.
    OMAi GNIPPVR.
    OrthoDBi EOG7W1543.
    PhylomeDBi Q7TNL3.
    TreeFami TF329785.

    Miscellaneous databases

    ChiTaRSi STK40. mouse.
    NextBioi 340002.
    PROi Q7TNL3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TNL3.
    Bgeei Q7TNL3.
    CleanExi MM_STK40.
    Genevestigatori Q7TNL3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024236. Ser/Thr_kinase_40.
    IPR008271. Ser/Thr_kinase_AS.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view ]
    PANTHERi PTHR22961. PTHR22961. 1 hit.
    PTHR22961:SF1. PTHR22961:SF1. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human, mouse, rat, chick and frog lyk4 gene."
      Shan Y.X., Yu L.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system."
      Matsuki T., Hori G., Furuichi T.
      Brain Res. Mol. Brain Res. 136:231-254(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J, ICR and NOD.
      Tissue: Brain and Tongue.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiSTK40_MOUSE
    AccessioniPrimary (citable) accession number: Q7TNL3
    Secondary accession number(s): B1AW01
    , Q3U3G3, Q811D6, Q8BKT1, Q9D7K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3