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Protein

ADM2

Gene

Adm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM2
Alternative name(s):
Intermedin
Cleaved into the following 2 chains:
Adrenomedullin-2
Short name:
AM2
Alternative name(s):
Intermedin-long
Short name:
IMDL
Intermedin-short
Short name:
IMDS
Gene namesi
Name:Adm2
Synonyms:Am2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2675256. Adm2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 10075By similarityPRO_0000000980Add
BLAST
Peptidei103 – 14947Adrenomedullin-2By similarityPRO_0000000981Add
BLAST
Peptidei110 – 14940Intermedin-shortSequence analysisPRO_0000000982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 117By similarity
Modified residuei149 – 1491Tyrosine amideCurated

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ7TNK8.
PRIDEiQ7TNK8.

PTM databases

PhosphoSiteiQ7TNK8.

Expressioni

Tissue specificityi

High expression detected in the submaxillary gland, kidney, stomach, and mesentery, followed by the pituitary, lung, pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the intermediate lobe of the pituitary, with sporadic in the anterior lobe.2 Publications

Gene expression databases

BgeeiQ7TNK8.
CleanExiMM_ADM2.
GenevisibleiQ7TNK8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064761.

Structurei

3D structure databases

ProteinModelPortaliQ7TNK8.
SMRiQ7TNK8. Positions 97-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3UK. Eukaryota.
ENOG410Z5UT. LUCA.
GeneTreeiENSGT00530000064523.
HOGENOMiHOG000033820.
HOVERGENiHBG048691.
InParanoidiQ7TNK8.
OMAiPAMGHPL.
OrthoDBiEOG74N5JJ.
PhylomeDBiQ7TNK8.
TreeFamiTF338591.

Family and domain databases

InterProiIPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLLMVTVT LGCISLLYLL PGTLSGSLGK GLRHSRPREP PAKIPSSNLQ
60 70 80 90 100
PGHPSLQPVV WKSRRHAPQP QGRGNRALAM VHLPQGGGSR HPGPQRPTGS
110 120 130 140 150
RRPHAQLLRV GCVLGTCQVQ NLSHRLWQLV RPAGRRDSAP VDPSSPHSYG
Length:150
Mass (Da):16,188
Last modified:October 1, 2003 - v1
Checksum:i2BFF392BFBFDEBBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529212 mRNA. Translation: AAQ09099.1.
AB121035 mRNA. Translation: BAD07412.1.
BC096428 mRNA. Translation: AAH96428.1.
CCDSiCCDS27744.1.
RefSeqiNP_891558.1. NM_182928.5.
UniGeneiMm.210541.

Genome annotation databases

EnsembliENSMUST00000066991; ENSMUSP00000064761; ENSMUSG00000054136.
GeneIDi223780.
KEGGimmu:223780.
UCSCiuc007xgb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529212 mRNA. Translation: AAQ09099.1.
AB121035 mRNA. Translation: BAD07412.1.
BC096428 mRNA. Translation: AAH96428.1.
CCDSiCCDS27744.1.
RefSeqiNP_891558.1. NM_182928.5.
UniGeneiMm.210541.

3D structure databases

ProteinModelPortaliQ7TNK8.
SMRiQ7TNK8. Positions 97-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064761.

PTM databases

PhosphoSiteiQ7TNK8.

Proteomic databases

PaxDbiQ7TNK8.
PRIDEiQ7TNK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066991; ENSMUSP00000064761; ENSMUSG00000054136.
GeneIDi223780.
KEGGimmu:223780.
UCSCiuc007xgb.2. mouse.

Organism-specific databases

CTDi79924.
MGIiMGI:2675256. Adm2.

Phylogenomic databases

eggNOGiENOG410J3UK. Eukaryota.
ENOG410Z5UT. LUCA.
GeneTreeiENSGT00530000064523.
HOGENOMiHOG000033820.
HOVERGENiHBG048691.
InParanoidiQ7TNK8.
OMAiPAMGHPL.
OrthoDBiEOG74N5JJ.
PhylomeDBiQ7TNK8.
TreeFamiTF338591.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

NextBioi376902.
PROiQ7TNK8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TNK8.
CleanExiMM_ADM2.
GenevisibleiQ7TNK8. MM.

Family and domain databases

InterProiIPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes."
    Roh J., Chang C.L., Bhalla A., Klein C., Hsu S.Y.T.
    J. Biol. Chem. 279:7264-7274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator."
    Takei Y., Inoue K., Ogoshi M., Kawahara T., Bannai H., Miyano S.
    FEBS Lett. 556:53-58(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiADM2_MOUSE
AccessioniPrimary (citable) accession number: Q7TNK8
Secondary accession number(s): Q4VAE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: November 11, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.