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Protein

ADM2

Gene

Adm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
ADM2
Alternative name(s):
Intermedin
Cleaved into the following 2 chains:
Adrenomedullin-2
Short name:
AM2
Alternative name(s):
Intermedin-long
Short name:
IMDL
Intermedin-short
Short name:
IMDS
Gene namesi
Name:Adm2
Synonyms:Am2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2675256 Adm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
PropeptideiPRO_000000098026 – 100By similarityAdd BLAST75
PeptideiPRO_0000000981103 – 149Adrenomedullin-2By similarityAdd BLAST47
PeptideiPRO_0000000982110 – 149Intermedin-shortSequence analysisAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 117By similarity
Modified residuei149Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ7TNK8
PRIDEiQ7TNK8

PTM databases

iPTMnetiQ7TNK8
PhosphoSitePlusiQ7TNK8

Expressioni

Tissue specificityi

High expression detected in the submaxillary gland, kidney, stomach, and mesentery, followed by the pituitary, lung, pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the intermediate lobe of the pituitary, with sporadic in the anterior lobe.2 Publications

Gene expression databases

BgeeiENSMUSG00000054136
CleanExiMM_ADM2
GenevisibleiQ7TNK8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064761

Structurei

3D structure databases

ProteinModelPortaliQ7TNK8
SMRiQ7TNK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3UK Eukaryota
ENOG410Z5UT LUCA
GeneTreeiENSGT00530000064523
HOGENOMiHOG000033820
HOVERGENiHBG048691
InParanoidiQ7TNK8
OMAiPAMGHPL
OrthoDBiEOG091G0ZSV
PhylomeDBiQ7TNK8
TreeFamiTF338591

Family and domain databases

InterProiView protein in InterPro
IPR021116 Calcitonin/adrenomedullin
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLLMVTVT LGCISLLYLL PGTLSGSLGK GLRHSRPREP PAKIPSSNLQ
60 70 80 90 100
PGHPSLQPVV WKSRRHAPQP QGRGNRALAM VHLPQGGGSR HPGPQRPTGS
110 120 130 140 150
RRPHAQLLRV GCVLGTCQVQ NLSHRLWQLV RPAGRRDSAP VDPSSPHSYG
Length:150
Mass (Da):16,188
Last modified:October 1, 2003 - v1
Checksum:i2BFF392BFBFDEBBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529212 mRNA Translation: AAQ09099.1
AB121035 mRNA Translation: BAD07412.1
BC096428 mRNA Translation: AAH96428.1
CCDSiCCDS27744.1
RefSeqiNP_891558.1, NM_182928.5
UniGeneiMm.210541

Genome annotation databases

EnsembliENSMUST00000066991; ENSMUSP00000064761; ENSMUSG00000054136
GeneIDi223780
KEGGimmu:223780
UCSCiuc007xgb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiADM2_MOUSE
AccessioniPrimary (citable) accession number: Q7TNK8
Secondary accession number(s): Q4VAE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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