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Protein

Ammonium transporter Rh type A

Gene

Rhag

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type A
Alternative name(s):
Erythrocyte membrane glycoprotein Rh50
Rhesus blood group family type A glycoprotein
Short name:
Rh family type A glycoprotein
Short name:
Rh type A glycoprotein
CD_antigen: CD241
Gene namesi
Name:Rhag
Synonyms:Rh50
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61871. Rhag.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 72ExtracellularSequence analysisAdd BLAST47
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 97CytoplasmicSequence analysis4
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 134ExtracellularSequence analysisAdd BLAST16
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 159CytoplasmicSequence analysis4
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 189ExtracellularSequence analysis9
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 229CytoplasmicSequence analysisAdd BLAST19
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 260ExtracellularSequence analysis10
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 289CytoplasmicSequence analysis8
Transmembranei290 – 307HelicalSequence analysisAdd BLAST18
Topological domaini308 – 311ExtracellularSequence analysis4
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 349CytoplasmicSequence analysisAdd BLAST17
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 384ExtracellularSequence analysisAdd BLAST14
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 450CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003801911 – 450Ammonium transporter Rh type AAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TNK7.

PTM databases

iPTMnetiQ7TNK7.
PhosphoSitePlusiQ7TNK7.

Interactioni

Subunit structurei

Heterotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065437.

Structurei

3D structure databases

ProteinModelPortaliQ7TNK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOGENOMiHOG000007656.
InParanoidiQ7TNK7.
KOiK06580.
PhylomeDBiQ7TNK7.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 2 hits.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TNK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKFSLIAL SLEVVMIVSF ALFVEYETSQ NGSQKSASQQ NASQQNAAAQ
60 70 80 90 100
QNASQQGNAS SPAKEDQFFQ LYPLFQHVHV MIFVGFGFLM TFLKKYGFSG
110 120 130 140 150
VGFNLFLAAL GLQWGTIVQG LLHSHGLKFP FRIKNMINAD FSTATVLISF
160 170 180 190 200
GAVLGKTSPI QMIIMTILEI AVFAGNEHLV TEIFKASDTG ASMTIHAFGA
210 220 230 240 250
YFGLAVAGVL YRSGLKHGHP NEESVYHSDL FAMIGTLFLW MFWPSFNSAI
260 270 280 290 300
AQPENNQYRA IVNTYMSLAA CVITAYALSS LVERRGRLDM VHIQNATLAG
310 320 330 340 350
GVAVGTCADM EIPLYFAMTI GSIAGIISVL GYKFLSPLLA HKLMIHDTCG
360 370 380 390 400
VHNLHGLPGV FGGLASIVAI SWGKSTVSTM AMQATALGSS IGSAIVGGLV
410 420 430 440 450
TGLILKLPVW NQPPDEYCFD DSVSWKVPKY RELDNYFFQH VTHNHVEHEV
Length:450
Mass (Da):49,062
Last modified:October 1, 2003 - v1
Checksum:iD5F1BBCE45D6335D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38S → P in BAA32443 (PubMed:9705835).Curated1
Sequence conflicti301G → S in BAA32443 (PubMed:9705835).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015194 mRNA. Translation: BAA32443.1.
AF531097 mRNA. Translation: AAQ10014.1.
RefSeqiNP_075411.2. NM_023022.2.
UniGeneiRn.44480.

Genome annotation databases

GeneIDi65207.
KEGGirno:65207.
UCSCiRGD:61871. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015194 mRNA. Translation: BAA32443.1.
AF531097 mRNA. Translation: AAQ10014.1.
RefSeqiNP_075411.2. NM_023022.2.
UniGeneiRn.44480.

3D structure databases

ProteinModelPortaliQ7TNK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065437.

PTM databases

iPTMnetiQ7TNK7.
PhosphoSitePlusiQ7TNK7.

Proteomic databases

PaxDbiQ7TNK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65207.
KEGGirno:65207.
UCSCiRGD:61871. rat.

Organism-specific databases

CTDi6005.
RGDi61871. Rhag.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOGENOMiHOG000007656.
InParanoidiQ7TNK7.
KOiK06580.
PhylomeDBiQ7TNK7.

Miscellaneous databases

PROiQ7TNK7.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 2 hits.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHAG_RAT
AccessioniPrimary (citable) accession number: Q7TNK7
Secondary accession number(s): O88300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.