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Protein

tRNA (guanine(10)-N2)-methyltransferase homolog

Gene

Trmt11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine(10)-N2)-methyltransferase homolog (EC:2.1.1.-)
Alternative name(s):
tRNA guanosine-2'-O-methyltransferase TRM11 homolog
Gene namesi
Name:Trmt11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727798. Trmt11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002302912 – 463tRNA (guanine(10)-N2)-methyltransferase homologAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ7TNK6.
PRIDEiQ7TNK6.

PTM databases

iPTMnetiQ7TNK6.
PhosphoSitePlusiQ7TNK6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019436.

Structurei

3D structure databases

ProteinModelPortaliQ7TNK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2671. Eukaryota.
COG1041. LUCA.
HOGENOMiHOG000191866.
HOVERGENiHBG097974.
InParanoidiQ7TNK6.
KOiK15430.
PhylomeDBiQ7TNK6.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR016691. tRNA_mtfrase_TRM11.
[Graphical view]
PfamiPF01170. UPF0020. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
PS51627. SAM_MT_TRM11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPGSLNRY LLLMAQEHLE FRLPEIKSLL SVIGGQFTNS QETYGKSPFW
60 70 80 90 100
ILNIPSEDIA RNLMKRTVCA KSLFELWGHG KSPEELYSSL KSYPVEKMVP
110 120 130 140 150
FLHSDSTYKI KIHTFNKTLT QEEKVKRIDA LEFLPFEGKV NLKKPQHVFS
160 170 180 190 200
ILEDYGLDPN CIPENPHNIY FGRWIADGQR ELIESYSVKK RHFIGNTSMD
210 220 230 240 250
AGLSFIMANH AKVKENDLVF DPFVGTGGLL IASAHFGAYV CGTDIDYNTV
260 270 280 290 300
HGLGKASRKN QKWRGPDENI RANLRQYGLE KFYLDVLVSD ASKPSWRKGT
310 320 330 340 350
YFDAIITDPP YGIRESTRRT GSQKEILKGI EKCPESHVPV SLTYHLSDMF
360 370 380 390 400
LDLINFAAET LVLGGRLVYW LPVYTPEYTE KMVPWHPCLR LVSNCEQKLS
410 420 430 440 450
SHTARRLITM EKVKEFENPD EYSRLLSDHF LPYQGHNSFR EKYFSGVTKR
460
IATEEQCSHE GKL
Length:463
Mass (Da):53,103
Last modified:October 1, 2003 - v1
Checksum:iA3AB4D43B7630177
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532978 mRNA. Translation: AAQ10285.1.
RefSeqiNP_932168.1. NM_198051.1.
UniGeneiRn.214011.

Genome annotation databases

GeneIDi378794.
KEGGirno:378794.
UCSCiRGD:727798. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532978 mRNA. Translation: AAQ10285.1.
RefSeqiNP_932168.1. NM_198051.1.
UniGeneiRn.214011.

3D structure databases

ProteinModelPortaliQ7TNK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019436.

PTM databases

iPTMnetiQ7TNK6.
PhosphoSitePlusiQ7TNK6.

Proteomic databases

PaxDbiQ7TNK6.
PRIDEiQ7TNK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378794.
KEGGirno:378794.
UCSCiRGD:727798. rat.

Organism-specific databases

CTDi60487.
RGDi727798. Trmt11.

Phylogenomic databases

eggNOGiKOG2671. Eukaryota.
COG1041. LUCA.
HOGENOMiHOG000191866.
HOVERGENiHBG097974.
InParanoidiQ7TNK6.
KOiK15430.
PhylomeDBiQ7TNK6.

Miscellaneous databases

PROiQ7TNK6.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR016691. tRNA_mtfrase_TRM11.
[Graphical view]
PfamiPF01170. UPF0020. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
PS51627. SAM_MT_TRM11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM11_RAT
AccessioniPrimary (citable) accession number: Q7TNK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.