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Protein

Zinc finger protein 24

Gene

Znf24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri251 – 27323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 24
Alternative name(s):
Zinc finger protein 191
Short name:
Zfp-191
Gene namesi
Name:Znf24
Synonyms:Zfp191, Znf191
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi727963. Zfp191.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Zinc finger protein 24PRO_0000366922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki27 – 27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki27 – 27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineBy similarity
Modified residuei274 – 2741PhosphoserineBy similarity
Cross-linki277 – 277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei292 – 2921PhosphoserineBy similarity
Modified residuei335 – 3351PhosphotyrosineBy similarity

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7TNK3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016562.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022304.

Structurei

3D structure databases

ProteinModelPortaliQ7TNK3.
SMRiQ7TNK3. Positions 44-135, 249-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 13483SCAN boxPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 30151Necessary and sufficient for nuclear localizationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri251 – 27323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ7TNK3.
KOiK09230.
OMAiILIIPNP.
OrthoDBiEOG091G09O3.
PhylomeDBiQ7TNK3.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPNPDEE EKILRVKLEE DPDGEEGSSI SWNHLPDPEI
60 70 80 90 100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF
110 120 130 140 150
VAILPRELQT LVREHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV
160 170 180 190 200
LVEEIASQED AQGLPSSELD AVENQLKWAS WELHSLRHCD DDATAENGAL
210 220 230 240 250
APKQEIASAG ESHEVPGTLN IGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ
260 270 280 290 300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
310 320 330 340 350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL
360
FRHQRRHNAE KLLNVVKV
Length:368
Mass (Da):41,910
Last modified:October 1, 2003 - v1
Checksum:iD0E1A13347CB875F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336973 mRNA. Translation: AAQ16149.1.
RefSeqiNP_892000.1. NM_182955.1.
XP_006254526.1. XM_006254464.2.
XP_006254527.1. XM_006254465.2.
UniGeneiRn.162286.
Rn.6583.

Genome annotation databases

EnsembliENSRNOT00000022304; ENSRNOP00000022304; ENSRNOG00000016562.
GeneIDi360204.
KEGGirno:360204.
UCSCiRGD:727963. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336973 mRNA. Translation: AAQ16149.1.
RefSeqiNP_892000.1. NM_182955.1.
XP_006254526.1. XM_006254464.2.
XP_006254527.1. XM_006254465.2.
UniGeneiRn.162286.
Rn.6583.

3D structure databases

ProteinModelPortaliQ7TNK3.
SMRiQ7TNK3. Positions 44-135, 249-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022304.

Proteomic databases

PaxDbiQ7TNK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022304; ENSRNOP00000022304; ENSRNOG00000016562.
GeneIDi360204.
KEGGirno:360204.
UCSCiRGD:727963. rat.

Organism-specific databases

CTDi59057.
RGDi727963. Zfp191.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ7TNK3.
KOiK09230.
OMAiILIIPNP.
OrthoDBiEOG091G09O3.
PhylomeDBiQ7TNK3.
TreeFamiTF338304.

Miscellaneous databases

PROiQ7TNK3.

Gene expression databases

BgeeiENSRNOG00000016562.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF24_RAT
AccessioniPrimary (citable) accession number: Q7TNK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.