Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine incorporator 1

Gene

Serinc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein binding, bridging Source: BHF-UCL

GO - Biological processi

  • membrane biogenesis Source: BHF-UCL
  • phosphatidylserine metabolic process Source: HGNC
  • phospholipid biosynthetic process Source: UniProtKB-KW
  • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: BHF-UCL
  • positive regulation of serine C-palmitoyltransferase activity Source: BHF-UCL
  • sphingolipid metabolic process Source: HGNC

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:Serinc1
Synonyms:Tde1l, Tde2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi727843 Serinc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88LumenalSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 123CytoplasmicSequence analysisAdd BLAST14
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 151LumenalSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 197CytoplasmicSequence analysisAdd BLAST25
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231LumenalSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 259CytoplasmicSequence analysis7
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 309LumenalSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 387CytoplasmicSequence analysisAdd BLAST57
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 426LumenalSequence analysisAdd BLAST18
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 453CytoplasmicSequence analysis6

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003159952 – 453Serine incorporator 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei352PhosphothreonineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ7TNK0
PRIDEiQ7TNK0

PTM databases

iPTMnetiQ7TNK0
PhosphoSitePlusiQ7TNK0

Expressioni

Tissue specificityi

Detected in brain cortex, hippocampus and cerebellar granule cell layer.1 Publication

Inductioni

Up-regulated by kainate treatment in neuronal cell layers of the hippocampus.1 Publication

Gene expression databases

BgeeiENSRNOG00000029360

Interactioni

Subunit structurei

Interacts with SPTLC1.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein binding, bridging Source: BHF-UCL

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001066

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ7TNK0
OMAiVCFGMAM
OrthoDBiEOG091G07WS
PhylomeDBiQ7TNK0
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029552 SERINC1
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAIILFFVYY THPASCSENK AFISVNMLLC IGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITIY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT
310 320 330 340 350
RPVPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGNGR SDGSLDDGEG VHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGIVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,553
Last modified:October 1, 2003 - v1
Checksum:i1DB300318421A4C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339894 mRNA Translation: AAQ17069.1
DQ103708 mRNA Translation: AAZ80295.1
BC088852 mRNA Translation: AAH88852.1
RefSeqiNP_891996.1, NM_182951.1
UniGeneiRn.2078

Genome annotation databases

EnsembliENSRNOT00000001066; ENSRNOP00000001066; ENSRNOG00000029360
GeneIDi294421
KEGGirno:294421
UCSCiRGD:727843 rat

Similar proteinsi

Entry informationi

Entry nameiSERC1_RAT
AccessioniPrimary (citable) accession number: Q7TNK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health