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Protein

Serine incorporator 1

Gene

Serinc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.1 Publication

GO - Molecular functioni

  • L-serine transmembrane transporter activity Source: HGNC

GO - Biological processi

  • L-serine transport Source: HGNC
  • phosphatidylserine metabolic process Source: HGNC
  • phospholipid biosynthetic process Source: UniProtKB-KW
  • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: BHF-UCL
  • positive regulation of serine C-palmitoyltransferase activity Source: BHF-UCL
  • sphingolipid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:Serinc1
Synonyms:Tde1l, Tde2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi727843. Serinc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3938CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Topological domaini61 – 8828LumenalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 12314CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 1517LumenalSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 19725CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 23113LumenalSequence analysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence analysisAdd
BLAST
Topological domaini253 – 2597CytoplasmicSequence analysis
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Topological domaini281 – 30929LumenalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Topological domaini331 – 38757CytoplasmicSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Topological domaini409 – 42618LumenalSequence analysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence analysisAdd
BLAST
Topological domaini448 – 4536CytoplasmicSequence analysis

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: HGNC
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 453452Serine incorporator 1PRO_0000315995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei351 – 3511PhosphoserineBy similarity
Modified residuei352 – 3521PhosphothreonineBy similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei364 – 3641PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ7TNK0.
PRIDEiQ7TNK0.

PTM databases

iPTMnetiQ7TNK0.

Expressioni

Tissue specificityi

Detected in brain cortex, hippocampus and cerebellar granule cell layer.1 Publication

Inductioni

Up-regulated by kainate treatment in neuronal cell layers of the hippocampus.1 Publication

Interactioni

Subunit structurei

Interacts with SPTLC1.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001066.

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ7TNK0.
OMAiSSSWICI.
OrthoDBiEOG7TXKGQ.
PhylomeDBiQ7TNK0.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAIILFFVYY THPASCSENK AFISVNMLLC IGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITIY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT
310 320 330 340 350
RPVPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGNGR SDGSLDDGEG VHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGIVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,553
Last modified:October 1, 2003 - v1
Checksum:i1DB300318421A4C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339894 mRNA. Translation: AAQ17069.1.
DQ103708 mRNA. Translation: AAZ80295.1.
BC088852 mRNA. Translation: AAH88852.1.
RefSeqiNP_891996.1. NM_182951.1.
UniGeneiRn.2078.

Genome annotation databases

EnsembliENSRNOT00000001066; ENSRNOP00000001066; ENSRNOG00000029360.
GeneIDi294421.
KEGGirno:294421.
UCSCiRGD:727843. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339894 mRNA. Translation: AAQ17069.1.
DQ103708 mRNA. Translation: AAZ80295.1.
BC088852 mRNA. Translation: AAH88852.1.
RefSeqiNP_891996.1. NM_182951.1.
UniGeneiRn.2078.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001066.

PTM databases

iPTMnetiQ7TNK0.

Proteomic databases

PaxDbiQ7TNK0.
PRIDEiQ7TNK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001066; ENSRNOP00000001066; ENSRNOG00000029360.
GeneIDi294421.
KEGGirno:294421.
UCSCiRGD:727843. rat.

Organism-specific databases

CTDi57515.
RGDi727843. Serinc1.

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ7TNK0.
OMAiSSSWICI.
OrthoDBiEOG7TXKGQ.
PhylomeDBiQ7TNK0.
TreeFamiTF312881.

Miscellaneous databases

PROiQ7TNK0.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis."
    Inuzuka M., Hayakawa M., Ingi T.
    J. Biol. Chem. 280:35776-35783(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SPTLC1, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Rattus norvegicus tumor differentially expressed 1, like (Tde1l)."
    Zhou G., Li W., Yu L., Wang J., Zhao S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSERC1_RAT
AccessioniPrimary (citable) accession number: Q7TNK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.