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Q7TNJ7

- KCC1G_RAT

UniProt

Q7TNJ7 - KCC1G_RAT

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Protein

Calcium/calmodulin-dependent protein kinase type 1G

Gene

Camk1g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Enzyme regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin is thought to result in a conformational change and leads to activation through phosphorylation by CAMKK1 By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATPPROSITE-ProRule annotation
Active sitei143 – 1431Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: RGD

GO - Biological processi

  1. calcium-mediated signaling Source: RGD
  2. protein phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type 1G (EC:2.7.11.17)
Alternative name(s):
CaM kinase I gamma
Short name:
CaM kinase IG
Short name:
CaM-KI gamma
Short name:
CaMKI gamma
Short name:
CaMKIG
CaMK-like CREB kinase III
Short name:
CLICK III
Gene namesi
Name:Camk1g
Synonyms:Camkig
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi621800. Camk1g.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. calcium- and calmodulin-dependent protein kinase complex Source: Ensembl
  2. cytoplasm Source: RGD
  3. Golgi apparatus Source: UniProtKB-KW
  4. neuron projection Source: RGD
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Calcium/calmodulin-dependent protein kinase type 1GPRO_0000086086Add
BLAST

Post-translational modificationi

Prenylated on Cys-473.By similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ7TNJ7.
PRIDEiQ7TNJ7.

Expressioni

Gene expression databases

GenevestigatoriQ7TNJ7.

Structurei

3D structure databases

ProteinModelPortaliQ7TNJ7.
SMRiQ7TNJ7. Positions 16-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 277255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 31741Autoinhibitory domainAdd
BLAST
Regioni297 – 31822Calmodulin-bindingAdd
BLAST

Domaini

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.By similarity

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ7TNJ7.
KOiK08794.
OMAiPWINGNT.
OrthoDBiEOG7WHH9K.
PhylomeDBiQ7TNJ7.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7TNJ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKEEEDCS SWKKQTTNIR KTFIFMEVLG SGAFSEVFLV KQRVTGKLFA
60 70 80 90 100
LKCIKKSPAF RDSSLENEIA VLKRIKHENI VTLEDIYEST THYYLVMQLV
110 120 130 140 150
SGGELFDRIL ERGVYTEKDA SLVIQQVLSA VKYLHENGIV HRDLKPENLL
160 170 180 190 200
YLTPEENSKI MITDFGLSKM EQNGVMSTAC GTPGYVAPEV LAQKPYSKAV
210 220 230 240 250
DCWSIGVITY ILLCGYPPFY EETESKLFEK IKEGYYEFES PFWDDISESA
260 270 280 290 300
KDFICHLLEK DPNERYTCEK ALRHPWIDGN TALHRDIYPS VSLQIQKNFA
310 320 330 340 350
KSKWRQAFNA AAVVHHMRKL HMNLHSPSVR QEVENRPPVS PAPEVSRPGS
360 370 380 390 400
HDSSITEAPI LDPSTPLPAL TRLPCSHSSR PSAPGGRSLN CLVNGSLRIS
410 420 430 440 450
SSLVPMQQGP LATGPCGCCS SCLNIGNKGK SSYCSEPTLF RKANKKQNFK
460 470
SEVMVPVKAG GSTHCRAGQT GVCLIM
Length:476
Mass (Da):53,179
Last modified:October 1, 2003 - v1
Checksum:i70AD679B0C36B0E3
GO
Isoform 2 (identifier: Q7TNJ7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-476: QAFNAAAVVH...AGQTGVCLIM → ELQVRGHGTS...GIAEAAGLRQ

Show »
Length:377
Mass (Da):42,902
Checksum:i2583EE864A5C12FC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei306 – 476171QAFNA…VCLIM → ELQVRGHGTSESRWQHPLPG WADWGVSHNVIPGARVVFQE TRLALLCLSKLASALRKGSS KAGIAEAAGLRQ in isoform 2. 1 PublicationVSP_012139Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB101231 mRNA. Translation: BAC80242.1.
AB101232 mRNA. Translation: BAC80243.1.
D86557 mRNA. Translation: BAA19880.1.
RefSeqiNP_878262.1. NM_182842.1. [Q7TNJ7-1]
XP_006250532.1. XM_006250470.2. [Q7TNJ7-4]
UniGeneiRn.91453.

Genome annotation databases

EnsembliENSRNOT00000009158; ENSRNOP00000009158; ENSRNOG00000006470. [Q7TNJ7-1]
ENSRNOT00000044161; ENSRNOP00000041124; ENSRNOG00000006470. [Q7TNJ7-4]
GeneIDi171358.
KEGGirno:171358.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB101231 mRNA. Translation: BAC80242.1 .
AB101232 mRNA. Translation: BAC80243.1 .
D86557 mRNA. Translation: BAA19880.1 .
RefSeqi NP_878262.1. NM_182842.1. [Q7TNJ7-1 ]
XP_006250532.1. XM_006250470.2. [Q7TNJ7-4 ]
UniGenei Rn.91453.

3D structure databases

ProteinModelPortali Q7TNJ7.
SMRi Q7TNJ7. Positions 16-301.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q7TNJ7.
PRIDEi Q7TNJ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009158 ; ENSRNOP00000009158 ; ENSRNOG00000006470 . [Q7TNJ7-1 ]
ENSRNOT00000044161 ; ENSRNOP00000041124 ; ENSRNOG00000006470 . [Q7TNJ7-4 ]
GeneIDi 171358.
KEGGi rno:171358.

Organism-specific databases

CTDi 57172.
RGDi 621800. Camk1g.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118944.
HOGENOMi HOG000233016.
HOVERGENi HBG108055.
InParanoidi Q7TNJ7.
KOi K08794.
OMAi PWINGNT.
OrthoDBi EOG7WHH9K.
PhylomeDBi Q7TNJ7.
TreeFami TF314166.

Enzyme and pathway databases

BRENDAi 2.7.11.17. 5301.

Miscellaneous databases

NextBioi 622144.
PROi Q7TNJ7.

Gene expression databases

Genevestigatori Q7TNJ7.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain."
    Nishimura H., Sakagami H., Uezu A., Fukunaga K., Watanabe M., Kondo H.
    J. Neurochem. 85:1216-1227(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ENZYME ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms."
    Yokokura H., Terada O., Naito Y., Hidaka H.
    Biochim. Biophys. Acta 1338:8-12(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-309.
    Tissue: Brain.

Entry informationi

Entry nameiKCC1G_RAT
AccessioniPrimary (citable) accession number: Q7TNJ7
Secondary accession number(s): O08763, Q7TNJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3