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Reviewed, UniProtKB/Swiss-Prot Q7TNJ7 (KCC1G_RAT)

Last modified February 9, 2010. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Calcium/calmodulin-dependent protein kinase type 1G
    EC=2.7.11.17
Alternative name(s):
    CaM kinase I gamma
      Short name=CaM kinase IG
      Short name=CaM-KI gamma
      Short name=CaMKI gamma
      Short name=CaMKIG
    CaMK-like CREB kinase III
      Short name=CLICK III
Gene names
Name: Camk1g
Synonyms: Camkig
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Ref.1

Enzyme regulation

Activated by Ca2+/calmodulin. Binding of calmodulin is thought to result in a conformational change and leads to activation through phosphorylation by CAMKK1 By similarity.

Subcellular location

Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein By similarity Ref.1.

Domain

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate By similarity.

Post-translational modification

Prenylated on Cys-473 By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7TNJ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7TNJ7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     306-476: QAFNAAAVVH...AGQTGVCLIM → ELQVRGHGTS...GIAEAAGLRQ

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Calcium/calmodulin-dependent protein kinase type 1G
PRO_0000086086

Regions

Domain23 – 277255Protein kinase
Nucleotide binding29 – 379ATP By similarity
Region277 – 31741Autoinhibitory domain
Region297 – 31822Calmodulin-binding

Sites

Active site1431Proton acceptor By similarity
Binding site521ATP By similarity

Amino acid modifications

Modified residue1781Phosphothreonine By similarity

Natural variations

Alternative sequence306 – 476171QAFNA…VCLIM → ELQVRGHGTSESRWQHPLPG WADWGVSHNVIPGARVVFQE TRLALLCLSKLASALRKGSS KAGIAEAAGLRQ in isoform 2.
VSP_012139

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 70AD679B0C36B0E3

FASTA47653,179
        10         20         30         40         50         60 
MGRKEEEDCS SWKKQTTNIR KTFIFMEVLG SGAFSEVFLV KQRVTGKLFA LKCIKKSPAF 

        70         80         90        100        110        120 
RDSSLENEIA VLKRIKHENI VTLEDIYEST THYYLVMQLV SGGELFDRIL ERGVYTEKDA 

       130        140        150        160        170        180 
SLVIQQVLSA VKYLHENGIV HRDLKPENLL YLTPEENSKI MITDFGLSKM EQNGVMSTAC 

       190        200        210        220        230        240 
GTPGYVAPEV LAQKPYSKAV DCWSIGVITY ILLCGYPPFY EETESKLFEK IKEGYYEFES 

       250        260        270        280        290        300 
PFWDDISESA KDFICHLLEK DPNERYTCEK ALRHPWIDGN TALHRDIYPS VSLQIQKNFA 

       310        320        330        340        350        360 
KSKWRQAFNA AAVVHHMRKL HMNLHSPSVR QEVENRPPVS PAPEVSRPGS HDSSITEAPI 

       370        380        390        400        410        420 
LDPSTPLPAL TRLPCSHSSR PSAPGGRSLN CLVNGSLRIS SSLVPMQQGP LATGPCGCCS 

       430        440        450        460        470 
SCLNIGNKGK SSYCSEPTLF RKANKKQNFK SEVMVPVKAG GSTHCRAGQT GVCLIM

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Isoform 2.

Checksum: 2583EE864A5C12FC
Show »

FASTA37742,902

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References

[1]"Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain."
Nishimura H., Sakagami H., Uezu A., Fukunaga K., Watanabe M., Kondo H.
J. Neurochem. 85:1216-1227(2003) [PubMed: 12753081] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ENZYME ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms."
Yokokura H., Terada O., Naito Y., Hidaka H.
Biochim. Biophys. Acta 1338:8-12(1997) [PubMed: 9074610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-309.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB101231 mRNA. Translation: BAC80242.1.
AB101232 mRNA. Translation: BAC80243.1.
D86557 mRNA. Translation: BAA19880.1.
IPIIPI00339078.
IPI00480628.
RefSeqNP_878262.1.
UniGeneRn.91453

3D structure databases

SMRQ7TNJ7. Positions 16-301.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7TNJ7.

Genome annotation databases

EnsemblENSRNOT00000009158; ENSRNOP00000009158; ENSRNOG00000006470; Rattus norvegicus. [Genome view]
GeneID171358.
KEGGrno:171358.
NMPDRfig|10116.3.peg.9808.
UCSCNM_182842. rat.

Organism-specific databases

CTD171358.
RGD621800. Camk1g.

Phylogenomic databases

eggNOGroNOG11129.
HOVERGENQ7TNJ7.
InParanoidQ7TNJ7.
OMAINHMKKL.
OrthoDBEOG93N9Z4.
PhylomeDBQ7TNJ7.

Enzyme and pathway databases

BRENDA2.7.11.17. 248.

Gene expression databases

ArrayExpressQ7TNJ7.
GenevestigatorQ7TNJ7.
GermOnlineENSRNOG00000006470. Rattus norvegicus.

Family and domain databases

InterProIPR020636. Ca/CaM-dep_prot_kinase-like.
IPR015734. Ca/CaM-dep_prot_kinase1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PANTHERPTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit.
PTHR22982:SF34. CaMKI. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio622144.

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Entry information

Entry nameKCC1G_RAT
AccessionPrimary (citable) accession number: Q7TNJ7
Secondary accession number(s): O08763, Q7TNJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2003
Last modified: February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents