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Protein

ATP-binding cassette sub-family A member 7

Gene

Abca7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi839 – 8468ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1852 – 18598ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 7
Gene namesi
Name:Abca7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303134. Abca7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Topological domaini43 – 547505ExtracellularBy similarityAdd
BLAST
Transmembranei548 – 56821HelicalSequence analysisAdd
BLAST
Transmembranei591 – 61121HelicalSequence analysisAdd
BLAST
Transmembranei624 – 64421HelicalSequence analysisAdd
BLAST
Transmembranei653 – 67321HelicalSequence analysisAdd
BLAST
Transmembranei679 – 69921HelicalSequence analysisAdd
BLAST
Transmembranei733 – 75321HelicalSequence analysisAdd
BLAST
Transmembranei847 – 86721HelicalSequence analysisAdd
BLAST
Transmembranei1257 – 127721HelicalSequence analysisAdd
BLAST
Topological domaini1278 – 1562285ExtracellularBy similarityAdd
BLAST
Transmembranei1563 – 158321HelicalSequence analysisAdd
BLAST
Transmembranei1609 – 162921HelicalSequence analysisAdd
BLAST
Transmembranei1646 – 166621HelicalSequence analysisAdd
BLAST
Transmembranei1674 – 169421HelicalSequence analysisAdd
BLAST
Transmembranei1708 – 172821HelicalSequence analysisAdd
BLAST
Transmembranei1754 – 177421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: Alzheimers_University_of_Toronto
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: GO_Central
  • membrane Source: RGD
  • phagocytic cup Source: Alzheimers_University_of_Toronto
  • plasma membrane Source: RGD
  • ruffle membrane Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21702170ATP-binding cassette sub-family A member 7PRO_0000250676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 222By similarity
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1370 ↔ 1384By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TNJ2.
PRIDEiQ7TNJ2.

PTM databases

iPTMnetiQ7TNJ2.
PhosphoSiteiQ7TNJ2.

Expressioni

Tissue specificityi

Expressed in blood cells. Also detected in brain and ovary tissues (at protein level). Expressed in platelet.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063805.

Structurei

3D structure databases

ProteinModelPortaliQ7TNJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini805 – 1036232ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1818 – 2050233ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiQ7TNJ2.
KOiK05645.
PhylomeDBiQ7TNJ2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030369. ABCA7.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 5 hits.
PTHR19229:SF49. PTHR19229:SF49. 5 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFCTQLMLL LWKNYTYRRR QPIQLVVELL WPLFLFFILV AVRHSHPPLE
60 70 80 90 100
HHECHFPNKP LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS
110 120 130 140 150
LISRLLADAH TVLGGHSTQD MLAALGKLIP VLRAVGSGAW PQESNQPAKQ
160 170 180 190 200
GSVTELLEKI LQRASLETVL GQAQDSMRKF SDATRTVAQE LLTLPSLVEL
210 220 230 240 250
RALLRRPRGS AGSLELISEA LCSTKGPSSP GGLSLNWYEA NQINEFMGPE
260 270 280 290 300
LAPTLPDSSL SPACSEFVGA LDDHPVSRLL WRRLKPLILG KILFAPDTNF
310 320 330 340 350
TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQKLLD
360 370 380 390 400
VEGTGWQQQT PKGQKQLEAI RDFLDPSRGR YNWQEAHADM GRLAEILGQI
410 420 430 440 450
LECVSLDKLE AVPSEEALVS RALELLGERR LWAGIVFLSP EHPLDSSEPP
460 470 480 490 500
SPTTTGPGHL RVKIRMDIDD VTRTNKIRDK FWDPGPSADP LMDLRYVWGG
510 520 530 540 550
FVYLQDLLEQ AAVRVLSGRD SRAGLYLQQM PHPCYVDDVF LRVLSRSLPL
560 570 580 590 600
FLTLAWIYSV ALTVKAVVRE KETRLRETMR AMGLSRAVLW LGWFLSCLGP
610 620 630 640 650
FLVSAALLVL VLKLGNILPY SHPVVVFLFL AAFAVATVAQ SFLLSAFFSR
660 670 680 690 700
ANLAAACGGL AYFALYLPYV LCVAWRERLP LGGLLAVSLL SPVAFGFGCE
710 720 730 740 750
SLALLEEQGD GAQWHNLGTG PAEDVFSLAQ VSAFLLLDAV IYGLALWYLE
760 770 780 790 800
AVCPGQYGIP EPWNFPFRRS YWCGPGPPKS SVLAPAPQDP KVLVEEPPPG
810 820 830 840 850
LVPGVSIRGL KKHFRGSPQP ALRGLNLDFY EGHITAFLGH NGAGKTTTLS
860 870 880 890 900
ILSGLFPPSS GSASILGHDV QTNMAAIRPH LGICPQYNVL FDMLTVEEHV
910 920 930 940 950
WFYGRLKGVS AAAIDSEQEH LIRDVGLIPK RDTQTRHLSG GMQRKLSVAI
960 970 980 990 1000
AFVGGSRVVI MDEPTAGVDP ASRRGIWELL LKYREGRTLI LSTHHLDEAE
1010 1020 1030 1040 1050
LLGDRVAMVA SGSLCCCGSP LFLRRHLGCG YYLTLVKSSQ SLVTHDLKGD
1060 1070 1080 1090 1100
TEDPRREKKS GSEGKTADTV LTRDGPHRSS QVPAPDAVPV TPSAALILEL
1110 1120 1130 1140 1150
VQRHVPGAQL VEELPHELVL ALPYAGALDG SFATVFQELD QQLERLGLTG
1160 1170 1180 1190 1200
YGISDTNLEE IFLKVVEEAH AHGEGGDPRQ QQHLLTATPQ PHTGPEASVL
1210 1220 1230 1240 1250
ENGELAKLVL DPQAPKGSAP TTAQVQGWTL TCQQLRALLH KRFLLARRSR
1260 1270 1280 1290 1300
RGLFAQIVLP ALFVGLALFF TLIVPPFGQY PPLQLSPAMY GPQVSFFSED
1310 1320 1330 1340 1350
APADPNRMKL LEALLGEAGL QDPSVQGKGS RGSECTHSLA CYFTVPEVPP
1360 1370 1380 1390 1400
DVASILASGN WTPDSPSPAC QCSQPGARRL LPDCPAGAGG PPPPQAMAGF
1410 1420 1430 1440 1450
GEVVQNLTGR NVSDFLVKTY PSLVRRGLKT KKWVDEVRYG GFSLGGRDPD
1460 1470 1480 1490 1500
LPSGREVVRT VAEMRALLSP QPGNTLDRIL NNLTQWALGL DARNSLKIWF
1510 1520 1530 1540 1550
NNKGWHAMVA FVNRANNGLL RAFLPSGSVR HAHSITTLNH PLNLTKEQLS
1560 1570 1580 1590 1600
EATLIASSVD VLVSICVVFA MSFVPASFTL VLIEERITRA KHLQLVSGLP
1610 1620 1630 1640 1650
QTLYWLGNFL WDMCNYLVAV CIVVLIFLAF QQKAYVAPEN LPALLLLLLL
1660 1670 1680 1690 1700
YGWSITPLMY PASFFFSVPS TAYVVLTCIN LFIGINSSMA TFVLELLSDQ
1710 1720 1730 1740 1750
NLQEVSRILK QVFLIFPHFC LGRGLIDMVR NQAMADAFER LGDKQFQSPL
1760 1770 1780 1790 1800
RWDIIGKNLL AMVAQGPLFL LITLLLQHRN RLLPQPKSRL PPPLGEEDED
1810 1820 1830 1840 1850
VVRERERVTK GATQGDVLVL RDLTKVYRGQ RSPAVDHLCL GIPPGECFGL
1860 1870 1880 1890 1900
LGVNGAGKTS TFRMVTGDTL PSSGEAVLAG HNVAQEPSAA HRSMGYCPQS
1910 1920 1930 1940 1950
DAIFDLLTGR EHLELFARLR GVPEAQVAQT ALSGLVRLGL PSYADRPAGT
1960 1970 1980 1990 2000
YSGGNKRKLA TALALVGDPA VVFLDEPTTG MDPSARRFLW NNLLSVVREG
2010 2020 2030 2040 2050
RSVVLTSHSM EECEALCTRL AIMVNGRFRC LGSAQHLKSR FGAGHTLTLR
2060 2070 2080 2090 2100
VPPDQPEPAI AFIVTTFPDA ELREVHGSRL RFQLPPGGGC TLARVFRELA
2110 2120 2130 2140 2150
AQGKAHGVED FSVSQTTLEE VFLYFSKDQG EEEEGSGQET ETREVSTPGL
2160 2170
QHPKRVSRFL EDPSSVETVI
Length:2,170
Mass (Da):237,720
Last modified:October 1, 2003 - v1
Checksum:i003C8DF70B8744CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097814 mRNA. Translation: BAC81426.1.
RefSeqiNP_997481.1. NM_207598.1.
UniGeneiRn.25281.

Genome annotation databases

GeneIDi299609.
KEGGirno:299609.
UCSCiRGD:1303134. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097814 mRNA. Translation: BAC81426.1.
RefSeqiNP_997481.1. NM_207598.1.
UniGeneiRn.25281.

3D structure databases

ProteinModelPortaliQ7TNJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063805.

PTM databases

iPTMnetiQ7TNJ2.
PhosphoSiteiQ7TNJ2.

Proteomic databases

PaxDbiQ7TNJ2.
PRIDEiQ7TNJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi299609.
KEGGirno:299609.
UCSCiRGD:1303134. rat.

Organism-specific databases

CTDi10347.
RGDi1303134. Abca7.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiQ7TNJ2.
KOiK05645.
PhylomeDBiQ7TNJ2.

Miscellaneous databases

PROiQ7TNJ2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030369. ABCA7.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 5 hits.
PTHR19229:SF49. PTHR19229:SF49. 5 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of rat ABCA7 and its preferential expression in platelets."
    Sasaki M., Shoji A., Kubo Y., Nada S., Yamaguchi A.
    Biochem. Biophys. Res. Commun. 304:777-782(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Platelet.

Entry informationi

Entry nameiABCA7_RAT
AccessioniPrimary (citable) accession number: Q7TNJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.