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Protein
Submitted name:

Toll-like receptor 3

Gene

Tlr3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • double-stranded RNA binding Source: RGD
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  • cellular response to drug Source: RGD
  • cellular response to dsRNA Source: RGD
  • cellular response to exogenous dsRNA Source: RGD
  • cellular response to interferon-beta Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • defense response to virus Source: InterPro
  • male gonad development Source: RGD
  • microglial cell activation Source: RGD
  • MyD88-independent toll-like receptor signaling pathway Source: InterPro
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of chemokine production Source: InterPro
  • positive regulation of inflammatory response Source: InterPro
  • positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  • positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • response to dsRNA Source: RGD
  • response to virus Source: RGD
  • toll-like receptor 3 signaling pathway Source: InterPro
  • toll-like receptor signaling pathway Source: RGD

Keywordsi

Molecular functionReceptorSAAS annotationImported
Biological processImmunity, Innate immunitySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 3Imported
Gene namesi
Name:Tlr3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi735171 Tlr3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18
Transmembranei705 – 726HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

iPTMnetiQ7TNI8
PhosphoSitePlusiQ7TNI8

Structurei

3D structure databases

ProteinModelPortaliQ7TNI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini755 – 859TIRInterPro annotationAdd BLAST105

Sequence similaritiesi

Belongs to the Toll-like receptor family.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
HOGENOMiHOG000251618
HOVERGENiHBG023181
KOiK05401

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027173 TLR3
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR44599 PTHR44599, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 7 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 15 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 19 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TNI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGRSSYLIY SFGGLLSLWI LVVSSTNQCT VRYNVADCSH LKLTHIPDDL
60 70 80 90 100
PSNITVLNLT HNQLRGLPPA NFTRYSQLAL LDAGFNSISK LEPELCQILP
110 120 130 140 150
LLKVLNLQHN ELSQISDQTF AFCTNLTELH LMSNSIRKIK SNPFKNQKSL
160 170 180 190 200
IKLDLSHNGL SSTKLGTWVQ LENLQELLLA KNKIFALRNE ELDFLGNSSL
210 220 230 240 250
QKLDLSSNPL KEFSPGCFHA IGKLFVLLLN NAQLNLDLTE KLCWELSNTS
260 270 280 290 300
IQNLSLANNQ LLATSNSTFS GLKQTNLTSL DLSYNSLRDV GNDAFSWLPH
310 320 330 340 350
LKYLSLEYNN IQRLTPHSFR GLSNLRYLSL KRAFTKQSVA LASHPNIDDF
360 370 380 390 400
SFQWLKCLEH LNMDDNTIPG IKSNTFTGLV SLKYLSLSKT FTGLQTLTNE
410 420 430 440 450
TFVSLTHSPL LTLNLTKNHI SKIASGTFSW LGQLRILDLG LNEIEQELTG
460 470 480 490 500
QEWRGLGNIF EIYLSYNKYL QLTSKSFTLV PSLQRLMLRR VALKSVDISP
510 520 530 540 550
SPFRPLYNLT ILDLSNNNIA NLNEDLLEGL ENLEILDFQH NNLARLWKHA
560 570 580 590 600
NPGGPVNFLK GLSHLHILNL ESNGLDEIPV KVFKNLFELK SINLGLNNLN
610 620 630 640 650
TLLPSIFDDQ TSLRSLNLQK NLITSVEKSV FGPAFHNLNS LDMSFNPFDC
660 670 680 690 700
TCESIAWFVT WLNQTHTNIP ELSTHYLCNT PQRYHGLPVK LFDTSSCKDS
710 720 730 740 750
APFQLLFIIN TSTLLTFILA VLLIHFEGWR ISFYWNVSVH RILGFKEIDA
760 770 780 790 800
QGEQFEYTAY IIHAQKDRDW VWEHFSPMEE QDQSLKFCLE ERDFEAGVLG
810 820 830 840 850
LEAIVNSIKR SRKIIFVITH HLLKDPLCRR FKVHHAVQQA IEQNLDSIIL
860 870 880 890 900
IFLQNIPDYK LNHALCLRRG MFKSHCILNW PIQKERINAF HHKLQVALGS

RNSAH
Length:905
Mass (Da):103,175
Last modified:October 1, 2003 - v1
Checksum:i478326F3A695D3D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116229 mRNA Translation: BAC81504.1
RefSeqiNP_942086.1, NM_198791.1
UniGeneiRn.15273

Genome annotation databases

GeneIDi364594
KEGGirno:364594

Similar proteinsi

Entry informationi

Entry nameiQ7TNI8_RAT
AccessioniPrimary (citable) accession number: Q7TNI8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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