Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Toll-like receptor 3

Gene

Tlr3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • receptor activity Source: RGD
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  • cellular response to drug Source: RGD
  • cellular response to dsRNA Source: RGD
  • cellular response to exogenous dsRNA Source: RGD
  • cellular response to interferon-beta Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • defense response to virus Source: InterPro
  • male gonad development Source: RGD
  • microglial cell activation Source: RGD
  • microglial cell activation involved in immune response Source: RGD
  • MyD88-independent toll-like receptor signaling pathway Source: InterPro
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of chemokine production Source: InterPro
  • positive regulation of inflammatory response Source: InterPro
  • positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  • positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • response to dsRNA Source: RGD
  • response to virus Source: RGD
  • toll-like receptor 3 signaling pathway Source: InterPro
  • toll-like receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 3Imported
Gene namesi
Name:Tlr3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi735171. Tlr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2418HelicalSequence analysisAdd
BLAST
Transmembranei705 – 72622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ7TNI8.
PRIDEiQ7TNI8.

PTM databases

PhosphoSiteiQ7TNI8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036680.

Structurei

3D structure databases

ProteinModelPortaliQ7TNI8.
SMRiQ7TNI8. Positions 28-698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini755 – 859105TIRInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000251618.
HOVERGENiHBG023181.
KOiK05401.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027173. TLR3.
[Graphical view]
PANTHERiPTHR24365:SF5. PTHR24365:SF5. 2 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 7 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 15 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 19 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGRSSYLIY SFGGLLSLWI LVVSSTNQCT VRYNVADCSH LKLTHIPDDL
60 70 80 90 100
PSNITVLNLT HNQLRGLPPA NFTRYSQLAL LDAGFNSISK LEPELCQILP
110 120 130 140 150
LLKVLNLQHN ELSQISDQTF AFCTNLTELH LMSNSIRKIK SNPFKNQKSL
160 170 180 190 200
IKLDLSHNGL SSTKLGTWVQ LENLQELLLA KNKIFALRNE ELDFLGNSSL
210 220 230 240 250
QKLDLSSNPL KEFSPGCFHA IGKLFVLLLN NAQLNLDLTE KLCWELSNTS
260 270 280 290 300
IQNLSLANNQ LLATSNSTFS GLKQTNLTSL DLSYNSLRDV GNDAFSWLPH
310 320 330 340 350
LKYLSLEYNN IQRLTPHSFR GLSNLRYLSL KRAFTKQSVA LASHPNIDDF
360 370 380 390 400
SFQWLKCLEH LNMDDNTIPG IKSNTFTGLV SLKYLSLSKT FTGLQTLTNE
410 420 430 440 450
TFVSLTHSPL LTLNLTKNHI SKIASGTFSW LGQLRILDLG LNEIEQELTG
460 470 480 490 500
QEWRGLGNIF EIYLSYNKYL QLTSKSFTLV PSLQRLMLRR VALKSVDISP
510 520 530 540 550
SPFRPLYNLT ILDLSNNNIA NLNEDLLEGL ENLEILDFQH NNLARLWKHA
560 570 580 590 600
NPGGPVNFLK GLSHLHILNL ESNGLDEIPV KVFKNLFELK SINLGLNNLN
610 620 630 640 650
TLLPSIFDDQ TSLRSLNLQK NLITSVEKSV FGPAFHNLNS LDMSFNPFDC
660 670 680 690 700
TCESIAWFVT WLNQTHTNIP ELSTHYLCNT PQRYHGLPVK LFDTSSCKDS
710 720 730 740 750
APFQLLFIIN TSTLLTFILA VLLIHFEGWR ISFYWNVSVH RILGFKEIDA
760 770 780 790 800
QGEQFEYTAY IIHAQKDRDW VWEHFSPMEE QDQSLKFCLE ERDFEAGVLG
810 820 830 840 850
LEAIVNSIKR SRKIIFVITH HLLKDPLCRR FKVHHAVQQA IEQNLDSIIL
860 870 880 890 900
IFLQNIPDYK LNHALCLRRG MFKSHCILNW PIQKERINAF HHKLQVALGS

RNSAH
Length:905
Mass (Da):103,175
Last modified:October 1, 2003 - v1
Checksum:i478326F3A695D3D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116229 mRNA. Translation: BAC81504.1.
RefSeqiNP_942086.1. NM_198791.1.
UniGeneiRn.15273.

Genome annotation databases

GeneIDi364594.
KEGGirno:364594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116229 mRNA. Translation: BAC81504.1.
RefSeqiNP_942086.1. NM_198791.1.
UniGeneiRn.15273.

3D structure databases

ProteinModelPortaliQ7TNI8.
SMRiQ7TNI8. Positions 28-698.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036680.

PTM databases

PhosphoSiteiQ7TNI8.

Proteomic databases

PaxDbiQ7TNI8.
PRIDEiQ7TNI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi364594.
KEGGirno:364594.

Organism-specific databases

CTDi7098.
RGDi735171. Tlr3.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000251618.
HOVERGENiHBG023181.
KOiK05401.

Miscellaneous databases

NextBioi685628.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027173. TLR3.
[Graphical view]
PANTHERiPTHR24365:SF5. PTHR24365:SF5. 2 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 7 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 15 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 19 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a gene encoding rat toll-like receptor 3."
    Tamura H., Oikawa A., Kato H.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ7TNI8_RAT
AccessioniPrimary (citable) accession number: Q7TNI8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.