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Protein

Interleukin-17F

Gene

Il17f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (By similarity). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (PubMed:15477493).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17F
Short name:
IL-17F
Gene namesi
Name:Il17f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2676631. Il17f.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 161133Interleukin-17FPRO_0000378104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 – 45Interchain (with C-135)By similarity
Glycosylationi83 – 831N-linked (GlcNAc...)By similarity
Disulfide bondi100 ↔ 150By similarity
Disulfide bondi105 ↔ 152By similarity
Disulfide bondi135 – 135Interchain (with C-35)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TNI7.
PRIDEiQ7TNI7.

Expressioni

Tissue specificityi

Expressed by a subset of activated T-cells in the lamina propria.1 Publication

Inductioni

Induced upon antigen receptor ligation in the presence of IL6 and TGB1.1 Publication

Gene expression databases

BgeeiQ7TNI7.
ExpressionAtlasiQ7TNI7. baseline and differential.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Heterodimer with IL17A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7TNI7. 2 interactions.
STRINGi10090.ENSMUSP00000046960.

Structurei

3D structure databases

ProteinModelPortaliQ7TNI7.
SMRiQ7TNI7. Positions 74-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYVF. Eukaryota.
ENOG410YVBI. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
InParanoidiQ7TNI7.
KOiK05494.
OMAiCPPLEDN.
OrthoDBiEOG70089V.
PhylomeDBiQ7TNI7.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TNI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKCTRETAMV KSLLLLMLGL AILREVAARK NPKAGVPALQ KAGNCPPLED
60 70 80 90 100
NTVRVDIRIF NQNQGISVPR EFQNRSSSPW DYNITRDPHR FPSEIAEAQC
110 120 130 140 150
RHSGCINAQG QEDSTMNSVA IQQEILVLRR EPQGCSNSFR LEKMLLKVGC
160
TCVKPIVHQA A
Length:161
Mass (Da):17,941
Last modified:October 1, 2003 - v1
Checksum:i649D57E491301CAA
GO
Isoform 2 (identifier: Q7TNI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Note: No experimental confirmation available.
Show »
Length:153
Mass (Da):17,020
Checksum:i894494F904ECCAAD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88Missing in isoform 2. 1 PublicationVSP_037499

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380822 mRNA. Translation: AAQ88439.1.
AB116259 mRNA. Translation: BAC81535.1.
AF458064 mRNA. Translation: AAM77568.1.
CCDSiCCDS35522.1. [Q7TNI7-1]
RefSeqiNP_665855.2. NM_145856.2. [Q7TNI7-1]
XP_006495585.1. XM_006495522.2. [Q7TNI7-1]
XP_006495586.1. XM_006495523.2. [Q7TNI7-1]
UniGeneiMm.222807.

Genome annotation databases

EnsembliENSMUST00000039046; ENSMUSP00000046960; ENSMUSG00000041872. [Q7TNI7-1]
GeneIDi257630.
KEGGimmu:257630.
UCSCiuc007akz.2. mouse. [Q7TNI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380822 mRNA. Translation: AAQ88439.1.
AB116259 mRNA. Translation: BAC81535.1.
AF458064 mRNA. Translation: AAM77568.1.
CCDSiCCDS35522.1. [Q7TNI7-1]
RefSeqiNP_665855.2. NM_145856.2. [Q7TNI7-1]
XP_006495585.1. XM_006495522.2. [Q7TNI7-1]
XP_006495586.1. XM_006495523.2. [Q7TNI7-1]
UniGeneiMm.222807.

3D structure databases

ProteinModelPortaliQ7TNI7.
SMRiQ7TNI7. Positions 74-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TNI7. 2 interactions.
STRINGi10090.ENSMUSP00000046960.

Proteomic databases

PaxDbiQ7TNI7.
PRIDEiQ7TNI7.

Protocols and materials databases

DNASUi257630.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039046; ENSMUSP00000046960; ENSMUSG00000041872. [Q7TNI7-1]
GeneIDi257630.
KEGGimmu:257630.
UCSCiuc007akz.2. mouse. [Q7TNI7-1]

Organism-specific databases

CTDi112744.
MGIiMGI:2676631. Il17f.

Phylogenomic databases

eggNOGiENOG410IYVF. Eukaryota.
ENOG410YVBI. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
InParanoidiQ7TNI7.
KOiK05494.
OMAiCPPLEDN.
OrthoDBiEOG70089V.
PhylomeDBiQ7TNI7.
TreeFamiTF314701.

Miscellaneous databases

NextBioi387445.
PROiQ7TNI7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TNI7.
ExpressionAtlasiQ7TNI7. baseline and differential.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Expression of IL-17F like cytokine in a mouse model of asthma."
    Kawaguchi M., Kokubu F., Suzuki S., Watanabe S., Ieki K., Matsukura S., Kurokawa M., Adachi M.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response."
    Oda N., Canelos P.B., Essayan D.M., Plunkett B.A., Myers A.C., Huang S.K.
    Am. J. Respir. Crit. Care Med. 171:12-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  3. Gilbert J.M., Gorman D.M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells."
    Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R.
    Cell 126:1121-1133(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IL6 AND TGFB1, TISSUE SPECIFICITY.
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiIL17F_MOUSE
AccessioniPrimary (citable) accession number: Q7TNI7
Secondary accession number(s): Q8K4C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.