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Protein

Interleukin-22 receptor subunit alpha-2

Gene

Il22ra2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei65Critical for IL22-bindingBy similarity1
Sitei117Critical for IL22-bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-8854691 Interleukin-20 family signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-2
Short name:
IL-22 receptor subunit alpha-2
Short name:
IL-22R-alpha-2
Short name:
IL-22RA2
Alternative name(s):
Cytokine receptor family type 2, soluble 1
Short name:
CRF2-S1
Interleukin-22-binding protein
Short name:
IL-22BP
Short name:
IL22BP
Gene namesi
Name:Il22ra2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303169 Il22ra2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001101820 – 229Interleukin-22 receptor subunit alpha-2Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 225By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TNI4
PRIDEiQ7TNI4

Expressioni

Gene expression databases

BgeeiENSRNOG00000012259
GenevisibleiQ7TNI4 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016354

Structurei

3D structure databases

ProteinModelPortaliQ7TNI4
SMRiQ7TNI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 127Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini128 – 229Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVX1 Eukaryota
ENOG410YNE2 LUCA
GeneTreeiENSGT00530000063352
HOGENOMiHOG000082681
HOVERGENiHBG052067
InParanoidiQ7TNI4
KOiK05139
OMAiPYYGRVR
OrthoDBiEOG091G068P
PhylomeDBiQ7TNI4
TreeFamiTF332537

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHCFLGLL IMLLTTATET QPAHVSLKPQ KVQFQSRNFH NILHWQPGNS
60 70 80 90 100
LTSNGSVYFV QYKTYGQGQW KDKNDCWGTT ALFCDLTKET LDPYEPYYGR
110 120 130 140 150
VMMAWAGSYS EWTRTPRFTP WWETKLDPPV VTITRVNASL RVRLRPPELP
160 170 180 190 200
HRNQTGKNTS MENYYNLVYR VSIINNSLEK EQKAYEGTQR AVEIQGLTPH
210 220
CSYCVVAEMY QPMFDRRSPR SKERCVQIP
Length:229
Mass (Da):26,722
Last modified:October 1, 2003 - v1
Checksum:i5CFFD37652A99365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555485 mRNA Translation: CAD88475.1
RefSeqiNP_001003404.1, NM_001003404.1
XP_017445017.1, XM_017589528.1
XP_017445018.1, XM_017589529.1
UniGeneiRn.13127

Genome annotation databases

EnsembliENSRNOT00000016354; ENSRNOP00000016354; ENSRNOG00000012259
GeneIDi444986
KEGGirno:444986
UCSCiRGD:1303169 rat

Similar proteinsi

Entry informationi

Entry nameiI22R2_RAT
AccessioniPrimary (citable) accession number: Q7TNI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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