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Protein

Interleukin-22 receptor subunit alpha-2

Gene

Il22ra2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei65 – 651Critical for IL22-bindingBy similarity
Sitei117 – 1171Critical for IL22-bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-2
Short name:
IL-22 receptor subunit alpha-2
Short name:
IL-22R-alpha-2
Short name:
IL-22RA2
Alternative name(s):
Cytokine receptor family type 2, soluble 1
Short name:
CRF2-S1
Interleukin-22-binding protein
Short name:
IL-22BP
Short name:
IL22BP
Gene namesi
Name:Il22ra2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303169. Il22ra2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 229210Interleukin-22 receptor subunit alpha-2PRO_0000011018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi204 ↔ 225By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TNI4.

Expressioni

Gene expression databases

GenevisibleiQ7TNI4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016354.

Structurei

3D structure databases

ProteinModelPortaliQ7TNI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 127100Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 229102Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVX1. Eukaryota.
ENOG410YNE2. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000082681.
HOVERGENiHBG052067.
InParanoidiQ7TNI4.
KOiK05139.
OMAiPYYGRVR.
OrthoDBiEOG7C2R12.
PhylomeDBiQ7TNI4.
TreeFamiTF332537.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHCFLGLL IMLLTTATET QPAHVSLKPQ KVQFQSRNFH NILHWQPGNS
60 70 80 90 100
LTSNGSVYFV QYKTYGQGQW KDKNDCWGTT ALFCDLTKET LDPYEPYYGR
110 120 130 140 150
VMMAWAGSYS EWTRTPRFTP WWETKLDPPV VTITRVNASL RVRLRPPELP
160 170 180 190 200
HRNQTGKNTS MENYYNLVYR VSIINNSLEK EQKAYEGTQR AVEIQGLTPH
210 220
CSYCVVAEMY QPMFDRRSPR SKERCVQIP
Length:229
Mass (Da):26,722
Last modified:October 1, 2003 - v1
Checksum:i5CFFD37652A99365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555485 mRNA. Translation: CAD88475.1.
RefSeqiNP_001003404.1. NM_001003404.1.
XP_006227726.1. XM_006227664.2.
UniGeneiRn.13127.

Genome annotation databases

EnsembliENSRNOT00000016354; ENSRNOP00000016354; ENSRNOG00000012259.
GeneIDi444986.
KEGGirno:444986.
UCSCiRGD:1303169. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555485 mRNA. Translation: CAD88475.1.
RefSeqiNP_001003404.1. NM_001003404.1.
XP_006227726.1. XM_006227664.2.
UniGeneiRn.13127.

3D structure databases

ProteinModelPortaliQ7TNI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016354.

Proteomic databases

PaxDbiQ7TNI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016354; ENSRNOP00000016354; ENSRNOG00000012259.
GeneIDi444986.
KEGGirno:444986.
UCSCiRGD:1303169. rat.

Organism-specific databases

CTDi116379.
RGDi1303169. Il22ra2.

Phylogenomic databases

eggNOGiENOG410IVX1. Eukaryota.
ENOG410YNE2. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000082681.
HOVERGENiHBG052067.
InParanoidiQ7TNI4.
KOiK05139.
OMAiPYYGRVR.
OrthoDBiEOG7C2R12.
PhylomeDBiQ7TNI4.
TreeFamiTF332537.

Miscellaneous databases

NextBioi697075.
PROiQ7TNI4.

Gene expression databases

GenevisibleiQ7TNI4. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart."
    Weiss B., Wolk K., Gruenberg B.H., Volk H.D., Sterry W., Asadullah K., Sabat R.
    Genes Immun. 5:330-336(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spleen.

Entry informationi

Entry nameiI22R2_RAT
AccessioniPrimary (citable) accession number: Q7TNI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.