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Q7TNI3

- Q7TNI3_MOUSE

UniProt

Q7TNI3 - Q7TNI3_MOUSE

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Protein
Submitted name: L-type dihydropyridine-sensitive calcium channel alpha-1f subunit
Gene
Cacna1f, Cav1.4
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. axonogenesis Source: MGI
  2. calcium ion import Source: RefGenome
  3. cellular calcium ion homeostasis Source: MGI
  4. dendrite morphogenesis Source: MGI
  5. detection of light stimulus involved in visual perception Source: Ensembl
  6. membrane depolarization during action potential Source: RefGenome
  7. retina development in camera-type eye Source: MGI
  8. visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
L-type dihydropyridine-sensitive calcium channel alpha-1f subunitImported
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1FImported
Gene namesi
Name:Cacna1fImported
Synonyms:Cav1.4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. perikaryon Source: Ensembl
  2. photoreceptor outer segment Source: Ensembl
  3. plasma membrane Source: RefGenome
  4. voltage-gated calcium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ7TNI3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117620.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
InParanoidiQ7TNI3.
KOiK04853.
OMAiAVKSTAC.
OrthoDBiEOG7T1RBQ.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNI3-1 [UniParc]FASTAAdd to Basket

« Hide

MSESEVGKDT TPEPSPANGT GPGPEWGLCP GPPTVGTDTS GASGLGTPRR     50
RTQHNKHKTV AVASAQRSPR ALFCLTLTNP IRRSCISIVE WKPFDILILL 100
TIFANCVALG VYIPFPEDDS NTANHNLEQV EYVFLVIFTV ETVLKIVAYG 150
LVLHPSAYIR NGWNLLDFII VVVGLFSVLL EQGPGRPGDA PHTGGKPGGF 200
DVKALRAFRV LRPLRLVSGV PSLHIVLNSI MKALVPLLHI ALLVLFVIII 250
YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR SCTLNHTECR 300
GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV 350
YFVSLVIFGS FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQMEED 400
LRGYLDWITQ AEELDLHDPS VDGNLASLAE EGRAGHRPQL SELTNRRRGR 450
LRWFSHSTRS THSTSSHASL PASDTGSMTD TPGDEDEEEG TMASCTRCLN 500
KIMKTRICRH FRRANRGLRA RCRRAVKSNA CYWAVLLLVF LNTLTIASEH 550
HGQPLWLTQT QEYANKVLLC LFTVEMLLKL YGLGPSVYVA SFFNRFDCFV 600
VCGGILETTL VEVGAMQPLG ISVLRCVRLL RIFKVTRHWA SLSNLVASLL 650
NSMKSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDQTHTK RSTFDTFPQA 700
LLTVFQILTG EDWNVVMYDG IMAYGGPFFP GMLVCVYFII LFICGNYILL 750
NVFLAIAVDN LASGDAGTAK DKGREKSSEG NPPKENKVLV PGGENEDAKG 800
ARSEGAAPGM EEEEEEEEEE EEEEEEENGA GHVELLQEVV PKEKVVPIPE 850
GSAFFCLSQT NPLRKACHTL IHHHIFTSLI LVFIILSSVS LAAEDPIRAH 900
SFRNHILGYF DYAFTSIFTV EILLKMTVFG AFLHRGSFCR SWFNLLDLLV 950
VSVSLISFGI HSSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI 1000
RTIGNIMIVT TLLQFMFACI GVQLFKGKFY SCTDEAKHTL KECKGSFLIY 1050
PDGDVSRPLV RERLWVNSDF NFDNVLSAMM ALFTVSTFEG WPALLYKAID 1100
ANAEDEGPIY NYHVEISVFF IVYIIIIAFF MMNIFVGFVI ITFRAQGEQE 1150
YQNCELDKNQ RQCVEYALKA QPLRRYIPKN PHQYRVWATV NSAAFEYLMF 1200
LLILLNTVAL AMQHYEQTAP FNYAMDILNM VFTGLFTIEM VLKIIAFKPK 1250
HYFADAWNTF DALIVVGSVV DIAVTEVNNG GHLGESSEDS SRISITFFRL 1300
FRVMRLVKLL SKGEGIRTLL WTFIKSFQAL PYVALLIAMI FFIYAVIGMQ 1350
MFGKVALQDG TQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLASLPGNR 1400
CDPESDFGPG EEFTCGSSFA IVYFISFFML CAFLIINLFV AVIMDNFDYL 1450
TRDWSILGPH HLDEFKRIWS EYDPGAKGRI KHLDVVALLR RIQPPLGFGK 1500
LCPHRVACKR LVAMNVPLNS DGTVTFNATL FALVRTSLKI KTEGNLDQAN 1550
QELRMVIKKI WKRIKQKLLD EVIPPPDEEE VTVGKFYATF LIQDYFRKFR 1600
RRKEKGLLGR EAPTSTSSAL QAGLRSLQDL GPEIRQALTY DTEEEEEEEE 1650
AVGQEAEEEE AENNPEPYKD SIDSQPQSRW NSRISVSLPV KEKLPDSLST 1700
GPSDDDGLAP NSRQPSVIQA GSQPHRRSSG VFMFTIPEEG SIQLKGTQGQ 1750
DNQNEEQEVP DWTPDLDEQA GTPSNPVLLP PHWSQQHVNG HHVPRRRLLP 1800
PTPAGRKPSF TIQCLQRQGS CEDLPIPGTY HRGRTSGPSR AQGSWAAPPQ 1850
KGRLLYAPLL LVEESTVGEG YLGKLGGPLR TFTCLQVPGA HPNPSHRKRG 1900
SADSLVEAVL ISEGLGLFAQ DPRFVALAKQ EIADACHLTL DEMDSAASDL 1950
LAQRTTSLYS DEESILSRFD EEDLGDEMAC VHAL 1984
Length:1,984
Mass (Da):221,827
Last modified:October 1, 2003 - v1
Checksum:iE193BF4CCBAD3882
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672231 Genomic DNA. No translation available.
AJ579852 mRNA. Translation: CAE30292.1.
RefSeqiNP_062528.2. NM_019582.2.
UniGeneiMm.289647.

Genome annotation databases

EnsembliENSMUST00000115726; ENSMUSP00000111391; ENSMUSG00000031142.
GeneIDi54652.
KEGGimmu:54652.
UCSCiuc009slp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672231 Genomic DNA. No translation available.
AJ579852 mRNA. Translation: CAE30292.1 .
RefSeqi NP_062528.2. NM_019582.2.
UniGenei Mm.289647.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 54652.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115726 ; ENSMUSP00000111391 ; ENSMUSG00000031142 .
GeneIDi 54652.
KEGGi mmu:54652.
UCSCi uc009slp.1. mouse.

Organism-specific databases

CTDi 778.
MGIi MGI:1859639. Cacna1f.

Phylogenomic databases

GeneTreei ENSGT00750000117620.
HOGENOMi HOG000231529.
HOVERGENi HBG050763.
InParanoidi Q7TNI3.
KOi K04853.
OMAi AVKSTAC.
OrthoDBi EOG7T1RBQ.
TreeFami TF312805.

Miscellaneous databases

NextBioi 311512.
SOURCEi Search...

Gene expression databases

Genevestigatori Q7TNI3.

Family and domain databases

Gene3Di 1.20.120.350. 5 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina."
    Baumann L., Gerstner A., Zong X., Biel M., Wahl-Scott C.
    Invest. Ophthalmol. Vis. Sci. 45:708-713(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57Bl6Imported.
    Tissue: EyeImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ7TNI3_MOUSE
AccessioniPrimary (citable) accession number: Q7TNI3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi