L-type dihydropyridine-sensitive calcium channel alpha-1f subunit

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Q7TNI3 (Q7TNI3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
L-type dihydropyridine-sensitive calcium channel alpha-1f subunit EMBL CAE30292.1

Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1F Ensembl ENSMUSP00000111391

Gene names

Name:	Cacna1f MGI 1859639 Ensembl ENSMUSP00000111391
Synonyms:	Cav1.4 EMBL CAE30292.1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1984 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ion channel Voltage-gated channel RuleBase RU003808
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from mutant phenotype PubMed 16155113. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 16155113. Source: MGI dendrite morphogenesis Inferred from mutant phenotype PubMed 16155113. Source: MGI detection of light stimulus involved in visual perception Inferred from electronic annotation. Source: Compara retina development in camera-type eye Inferred from mutant phenotype PubMed 21052544. Source: MGI visual perception Inferred from mutant phenotype PubMed 16155113. Source: MGI
Cellular_component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: Compara
Molecular_function	voltage-gated calcium channel activity Inferred from mutant phenotype PubMed 16155113. Source: MGI
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q7TNI3 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: E193BF4CCBAD3882
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FASTA

1,984

221,827

        10         20         30         40         50         60 
MSESEVGKDT TPEPSPANGT GPGPEWGLCP GPPTVGTDTS GASGLGTPRR RTQHNKHKTV 

        70         80         90        100        110        120 
AVASAQRSPR ALFCLTLTNP IRRSCISIVE WKPFDILILL TIFANCVALG VYIPFPEDDS 

       130        140        150        160        170        180 
NTANHNLEQV EYVFLVIFTV ETVLKIVAYG LVLHPSAYIR NGWNLLDFII VVVGLFSVLL 

       190        200        210        220        230        240 
EQGPGRPGDA PHTGGKPGGF DVKALRAFRV LRPLRLVSGV PSLHIVLNSI MKALVPLLHI 

       250        260        270        280        290        300 
ALLVLFVIII YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR SCTLNHTECR 

       310        320        330        340        350        360 
GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV YFVSLVIFGS 

       370        380        390        400        410        420 
FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQMEED LRGYLDWITQ AEELDLHDPS 

       430        440        450        460        470        480 
VDGNLASLAE EGRAGHRPQL SELTNRRRGR LRWFSHSTRS THSTSSHASL PASDTGSMTD 

       490        500        510        520        530        540 
TPGDEDEEEG TMASCTRCLN KIMKTRICRH FRRANRGLRA RCRRAVKSNA CYWAVLLLVF 

       550        560        570        580        590        600 
LNTLTIASEH HGQPLWLTQT QEYANKVLLC LFTVEMLLKL YGLGPSVYVA SFFNRFDCFV 

       610        620        630        640        650        660 
VCGGILETTL VEVGAMQPLG ISVLRCVRLL RIFKVTRHWA SLSNLVASLL NSMKSIASLL 

       670        680        690        700        710        720 
LLLFLFIIIF SLLGMQLFGG KFNFDQTHTK RSTFDTFPQA LLTVFQILTG EDWNVVMYDG 

       730        740        750        760        770        780 
IMAYGGPFFP GMLVCVYFII LFICGNYILL NVFLAIAVDN LASGDAGTAK DKGREKSSEG 

       790        800        810        820        830        840 
NPPKENKVLV PGGENEDAKG ARSEGAAPGM EEEEEEEEEE EEEEEEENGA GHVELLQEVV 

       850        860        870        880        890        900 
PKEKVVPIPE GSAFFCLSQT NPLRKACHTL IHHHIFTSLI LVFIILSSVS LAAEDPIRAH 

       910        920        930        940        950        960 
SFRNHILGYF DYAFTSIFTV EILLKMTVFG AFLHRGSFCR SWFNLLDLLV VSVSLISFGI 

       970        980        990       1000       1010       1020 
HSSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI RTIGNIMIVT TLLQFMFACI 

      1030       1040       1050       1060       1070       1080 
GVQLFKGKFY SCTDEAKHTL KECKGSFLIY PDGDVSRPLV RERLWVNSDF NFDNVLSAMM 

      1090       1100       1110       1120       1130       1140 
ALFTVSTFEG WPALLYKAID ANAEDEGPIY NYHVEISVFF IVYIIIIAFF MMNIFVGFVI 

      1150       1160       1170       1180       1190       1200 
ITFRAQGEQE YQNCELDKNQ RQCVEYALKA QPLRRYIPKN PHQYRVWATV NSAAFEYLMF 

      1210       1220       1230       1240       1250       1260 
LLILLNTVAL AMQHYEQTAP FNYAMDILNM VFTGLFTIEM VLKIIAFKPK HYFADAWNTF 

      1270       1280       1290       1300       1310       1320 
DALIVVGSVV DIAVTEVNNG GHLGESSEDS SRISITFFRL FRVMRLVKLL SKGEGIRTLL 

      1330       1340       1350       1360       1370       1380 
WTFIKSFQAL PYVALLIAMI FFIYAVIGMQ MFGKVALQDG TQINRNNNFQ TFPQAVLLLF 

      1390       1400       1410       1420       1430       1440 
RCATGEAWQE IMLASLPGNR CDPESDFGPG EEFTCGSSFA IVYFISFFML CAFLIINLFV 

      1450       1460       1470       1480       1490       1500 
AVIMDNFDYL TRDWSILGPH HLDEFKRIWS EYDPGAKGRI KHLDVVALLR RIQPPLGFGK 

      1510       1520       1530       1540       1550       1560 
LCPHRVACKR LVAMNVPLNS DGTVTFNATL FALVRTSLKI KTEGNLDQAN QELRMVIKKI 

      1570       1580       1590       1600       1610       1620 
WKRIKQKLLD EVIPPPDEEE VTVGKFYATF LIQDYFRKFR RRKEKGLLGR EAPTSTSSAL 

      1630       1640       1650       1660       1670       1680 
QAGLRSLQDL GPEIRQALTY DTEEEEEEEE AVGQEAEEEE AENNPEPYKD SIDSQPQSRW 

      1690       1700       1710       1720       1730       1740 
NSRISVSLPV KEKLPDSLST GPSDDDGLAP NSRQPSVIQA GSQPHRRSSG VFMFTIPEEG 

      1750       1760       1770       1780       1790       1800 
SIQLKGTQGQ DNQNEEQEVP DWTPDLDEQA GTPSNPVLLP PHWSQQHVNG HHVPRRRLLP 

      1810       1820       1830       1840       1850       1860 
PTPAGRKPSF TIQCLQRQGS CEDLPIPGTY HRGRTSGPSR AQGSWAAPPQ KGRLLYAPLL 

      1870       1880       1890       1900       1910       1920 
LVEESTVGEG YLGKLGGPLR TFTCLQVPGA HPNPSHRKRG SADSLVEAVL ISEGLGLFAQ 

      1930       1940       1950       1960       1970       1980 
DPRFVALAKQ EIADACHLTL DEMDSAASDL LAQRTTSLYS DEESILSRFD EEDLGDEMAC 


VHAL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina." Baumann L., Gerstner A., Zong X., Biel M., Wahl-Scott C. Invest. Ophthalmol. Vis. Sci. 45:708-713(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57Bl6 EMBL CAE30292.1. Tissue: Eye EMBL CAE30292.1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000111391.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000111391.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL672231 Genomic DNA. No translation available. AJ579852 mRNA. Translation: CAE30292.1.
IPI	IPI00875458.
RefSeq	NP_062528.2. NM_019582.2.
UniGene	Mm.289647.
3D structure databases
HSSP	HSSP built from PDB template 1T0J based on UniProtKB Q13933.
SMR	Q7TNI3. Positions 386-414, 1528-1608.
ModBase	Search...
Protocols and materials databases
DNASU	54652.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000115726; ENSMUSP00000111391; ENSMUSG00000031142.
GeneID	54652.
KEGG	mmu:54652.
UCSC	uc009slp.1. mouse.
Organism-specific databases
CTD	778.
MGI	MGI:1859639. Cacna1f.
Phylogenomic databases
GeneTree	ENSGT00680000099892.
HOGENOM	HOG000231529.
HOVERGEN	HBG050763.
InParanoid	Q7TNI3.
KO	K04853.
OrthoDB	EOG4W3SM2.
Gene expression databases
Genevestigator	Q7TNI3.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR014873. VDCC_a1su_IQ. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311512.
SOURCE	Search...

Entry information

Entry name

Q7TNI3_MOUSE

Accession

Primary (citable) accession number: Q7TNI3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information