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Q7TNI3

- Q7TNI3_MOUSE

UniProt

Q7TNI3 - Q7TNI3_MOUSE

Protein
Submitted name:

L-type dihydropyridine-sensitive calcium channel alpha-1f subunit

Gene

Cacna1f

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. high voltage-gated calcium channel activity Source: RefGenome
    2. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. calcium ion import Source: RefGenome
    3. cellular calcium ion homeostasis Source: MGI
    4. dendrite morphogenesis Source: MGI
    5. detection of light stimulus involved in visual perception Source: Ensembl
    6. membrane depolarization during action potential Source: RefGenome
    7. retina development in camera-type eye Source: MGI
    8. visual perception Source: MGI

    Keywords - Molecular functioni

    Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    L-type dihydropyridine-sensitive calcium channel alpha-1f subunitImported
    Submitted name:
    Voltage-dependent L-type calcium channel subunit alpha-1FImported
    Gene namesi
    Name:Cacna1fImported
    Synonyms:Cav1.4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1859639. Cacna1f.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. perikaryon Source: Ensembl
    2. photoreceptor outer segment Source: Ensembl
    3. plasma membrane Source: RefGenome
    4. voltage-gated calcium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TNI3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117620.
    HOGENOMiHOG000231529.
    HOVERGENiHBG050763.
    InParanoidiQ7TNI3.
    KOiK04853.
    OMAiAVKSTAC.
    OrthoDBiEOG7T1RBQ.
    TreeFamiTF312805.

    Family and domain databases

    Gene3Di1.20.120.350. 5 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    SMARTiSM01062. Ca_chan_IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TNI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESEVGKDT TPEPSPANGT GPGPEWGLCP GPPTVGTDTS GASGLGTPRR     50
    RTQHNKHKTV AVASAQRSPR ALFCLTLTNP IRRSCISIVE WKPFDILILL 100
    TIFANCVALG VYIPFPEDDS NTANHNLEQV EYVFLVIFTV ETVLKIVAYG 150
    LVLHPSAYIR NGWNLLDFII VVVGLFSVLL EQGPGRPGDA PHTGGKPGGF 200
    DVKALRAFRV LRPLRLVSGV PSLHIVLNSI MKALVPLLHI ALLVLFVIII 250
    YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR SCTLNHTECR 300
    GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV 350
    YFVSLVIFGS FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQMEED 400
    LRGYLDWITQ AEELDLHDPS VDGNLASLAE EGRAGHRPQL SELTNRRRGR 450
    LRWFSHSTRS THSTSSHASL PASDTGSMTD TPGDEDEEEG TMASCTRCLN 500
    KIMKTRICRH FRRANRGLRA RCRRAVKSNA CYWAVLLLVF LNTLTIASEH 550
    HGQPLWLTQT QEYANKVLLC LFTVEMLLKL YGLGPSVYVA SFFNRFDCFV 600
    VCGGILETTL VEVGAMQPLG ISVLRCVRLL RIFKVTRHWA SLSNLVASLL 650
    NSMKSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDQTHTK RSTFDTFPQA 700
    LLTVFQILTG EDWNVVMYDG IMAYGGPFFP GMLVCVYFII LFICGNYILL 750
    NVFLAIAVDN LASGDAGTAK DKGREKSSEG NPPKENKVLV PGGENEDAKG 800
    ARSEGAAPGM EEEEEEEEEE EEEEEEENGA GHVELLQEVV PKEKVVPIPE 850
    GSAFFCLSQT NPLRKACHTL IHHHIFTSLI LVFIILSSVS LAAEDPIRAH 900
    SFRNHILGYF DYAFTSIFTV EILLKMTVFG AFLHRGSFCR SWFNLLDLLV 950
    VSVSLISFGI HSSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI 1000
    RTIGNIMIVT TLLQFMFACI GVQLFKGKFY SCTDEAKHTL KECKGSFLIY 1050
    PDGDVSRPLV RERLWVNSDF NFDNVLSAMM ALFTVSTFEG WPALLYKAID 1100
    ANAEDEGPIY NYHVEISVFF IVYIIIIAFF MMNIFVGFVI ITFRAQGEQE 1150
    YQNCELDKNQ RQCVEYALKA QPLRRYIPKN PHQYRVWATV NSAAFEYLMF 1200
    LLILLNTVAL AMQHYEQTAP FNYAMDILNM VFTGLFTIEM VLKIIAFKPK 1250
    HYFADAWNTF DALIVVGSVV DIAVTEVNNG GHLGESSEDS SRISITFFRL 1300
    FRVMRLVKLL SKGEGIRTLL WTFIKSFQAL PYVALLIAMI FFIYAVIGMQ 1350
    MFGKVALQDG TQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLASLPGNR 1400
    CDPESDFGPG EEFTCGSSFA IVYFISFFML CAFLIINLFV AVIMDNFDYL 1450
    TRDWSILGPH HLDEFKRIWS EYDPGAKGRI KHLDVVALLR RIQPPLGFGK 1500
    LCPHRVACKR LVAMNVPLNS DGTVTFNATL FALVRTSLKI KTEGNLDQAN 1550
    QELRMVIKKI WKRIKQKLLD EVIPPPDEEE VTVGKFYATF LIQDYFRKFR 1600
    RRKEKGLLGR EAPTSTSSAL QAGLRSLQDL GPEIRQALTY DTEEEEEEEE 1650
    AVGQEAEEEE AENNPEPYKD SIDSQPQSRW NSRISVSLPV KEKLPDSLST 1700
    GPSDDDGLAP NSRQPSVIQA GSQPHRRSSG VFMFTIPEEG SIQLKGTQGQ 1750
    DNQNEEQEVP DWTPDLDEQA GTPSNPVLLP PHWSQQHVNG HHVPRRRLLP 1800
    PTPAGRKPSF TIQCLQRQGS CEDLPIPGTY HRGRTSGPSR AQGSWAAPPQ 1850
    KGRLLYAPLL LVEESTVGEG YLGKLGGPLR TFTCLQVPGA HPNPSHRKRG 1900
    SADSLVEAVL ISEGLGLFAQ DPRFVALAKQ EIADACHLTL DEMDSAASDL 1950
    LAQRTTSLYS DEESILSRFD EEDLGDEMAC VHAL 1984
    Length:1,984
    Mass (Da):221,827
    Last modified:October 1, 2003 - v1
    Checksum:iE193BF4CCBAD3882
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672231 Genomic DNA. No translation available.
    AJ579852 mRNA. Translation: CAE30292.1.
    RefSeqiNP_062528.2. NM_019582.2.
    UniGeneiMm.289647.

    Genome annotation databases

    EnsembliENSMUST00000115726; ENSMUSP00000111391; ENSMUSG00000031142.
    GeneIDi54652.
    KEGGimmu:54652.
    UCSCiuc009slp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672231 Genomic DNA. No translation available.
    AJ579852 mRNA. Translation: CAE30292.1 .
    RefSeqi NP_062528.2. NM_019582.2.
    UniGenei Mm.289647.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 54652.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115726 ; ENSMUSP00000111391 ; ENSMUSG00000031142 .
    GeneIDi 54652.
    KEGGi mmu:54652.
    UCSCi uc009slp.1. mouse.

    Organism-specific databases

    CTDi 778.
    MGIi MGI:1859639. Cacna1f.

    Phylogenomic databases

    GeneTreei ENSGT00750000117620.
    HOGENOMi HOG000231529.
    HOVERGENi HBG050763.
    InParanoidi Q7TNI3.
    KOi K04853.
    OMAi AVKSTAC.
    OrthoDBi EOG7T1RBQ.
    TreeFami TF312805.

    Miscellaneous databases

    NextBioi 311512.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q7TNI3.

    Family and domain databases

    Gene3Di 1.20.120.350. 5 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    SMARTi SM01062. Ca_chan_IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina."
      Baumann L., Gerstner A., Zong X., Biel M., Wahl-Scott C.
      Invest. Ophthalmol. Vis. Sci. 45:708-713(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57Bl6Imported.
      Tissue: EyeImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ7TNI3_MOUSE
    AccessioniPrimary (citable) accession number: Q7TNI3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3