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Q7TNI3

- Q7TNI3_MOUSE

UniProt

Q7TNI3 - Q7TNI3_MOUSE

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Protein
Submitted name:

L-type dihydropyridine-sensitive calcium channel alpha-1f subunit

Gene

Cacna1f

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. axonogenesis Source: MGI
  2. calcium ion import Source: RefGenome
  3. cellular calcium ion homeostasis Source: MGI
  4. dendrite morphogenesis Source: MGI
  5. detection of light stimulus involved in visual perception Source: Ensembl
  6. membrane depolarization during action potential Source: RefGenome
  7. retina development in camera-type eye Source: MGI
  8. visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
L-type dihydropyridine-sensitive calcium channel alpha-1f subunitImported
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1FImported
Gene namesi
Name:Cacna1fImported
Synonyms:Cav1.4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. perikaryon Source: Ensembl
  2. photoreceptor outer segment Source: Ensembl
  3. plasma membrane Source: RefGenome
  4. voltage-gated calcium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ7TNI3.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118827.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04853.
OMAiAVKSTAC.
OrthoDBiEOG7T1RBQ.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESEVGKDT TPEPSPANGT GPGPEWGLCP GPPTVGTDTS GASGLGTPRR
60 70 80 90 100
RTQHNKHKTV AVASAQRSPR ALFCLTLTNP IRRSCISIVE WKPFDILILL
110 120 130 140 150
TIFANCVALG VYIPFPEDDS NTANHNLEQV EYVFLVIFTV ETVLKIVAYG
160 170 180 190 200
LVLHPSAYIR NGWNLLDFII VVVGLFSVLL EQGPGRPGDA PHTGGKPGGF
210 220 230 240 250
DVKALRAFRV LRPLRLVSGV PSLHIVLNSI MKALVPLLHI ALLVLFVIII
260 270 280 290 300
YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR SCTLNHTECR
310 320 330 340 350
GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV
360 370 380 390 400
YFVSLVIFGS FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQMEED
410 420 430 440 450
LRGYLDWITQ AEELDLHDPS VDGNLASLAE EGRAGHRPQL SELTNRRRGR
460 470 480 490 500
LRWFSHSTRS THSTSSHASL PASDTGSMTD TPGDEDEEEG TMASCTRCLN
510 520 530 540 550
KIMKTRICRH FRRANRGLRA RCRRAVKSNA CYWAVLLLVF LNTLTIASEH
560 570 580 590 600
HGQPLWLTQT QEYANKVLLC LFTVEMLLKL YGLGPSVYVA SFFNRFDCFV
610 620 630 640 650
VCGGILETTL VEVGAMQPLG ISVLRCVRLL RIFKVTRHWA SLSNLVASLL
660 670 680 690 700
NSMKSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDQTHTK RSTFDTFPQA
710 720 730 740 750
LLTVFQILTG EDWNVVMYDG IMAYGGPFFP GMLVCVYFII LFICGNYILL
760 770 780 790 800
NVFLAIAVDN LASGDAGTAK DKGREKSSEG NPPKENKVLV PGGENEDAKG
810 820 830 840 850
ARSEGAAPGM EEEEEEEEEE EEEEEEENGA GHVELLQEVV PKEKVVPIPE
860 870 880 890 900
GSAFFCLSQT NPLRKACHTL IHHHIFTSLI LVFIILSSVS LAAEDPIRAH
910 920 930 940 950
SFRNHILGYF DYAFTSIFTV EILLKMTVFG AFLHRGSFCR SWFNLLDLLV
960 970 980 990 1000
VSVSLISFGI HSSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI
1010 1020 1030 1040 1050
RTIGNIMIVT TLLQFMFACI GVQLFKGKFY SCTDEAKHTL KECKGSFLIY
1060 1070 1080 1090 1100
PDGDVSRPLV RERLWVNSDF NFDNVLSAMM ALFTVSTFEG WPALLYKAID
1110 1120 1130 1140 1150
ANAEDEGPIY NYHVEISVFF IVYIIIIAFF MMNIFVGFVI ITFRAQGEQE
1160 1170 1180 1190 1200
YQNCELDKNQ RQCVEYALKA QPLRRYIPKN PHQYRVWATV NSAAFEYLMF
1210 1220 1230 1240 1250
LLILLNTVAL AMQHYEQTAP FNYAMDILNM VFTGLFTIEM VLKIIAFKPK
1260 1270 1280 1290 1300
HYFADAWNTF DALIVVGSVV DIAVTEVNNG GHLGESSEDS SRISITFFRL
1310 1320 1330 1340 1350
FRVMRLVKLL SKGEGIRTLL WTFIKSFQAL PYVALLIAMI FFIYAVIGMQ
1360 1370 1380 1390 1400
MFGKVALQDG TQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLASLPGNR
1410 1420 1430 1440 1450
CDPESDFGPG EEFTCGSSFA IVYFISFFML CAFLIINLFV AVIMDNFDYL
1460 1470 1480 1490 1500
TRDWSILGPH HLDEFKRIWS EYDPGAKGRI KHLDVVALLR RIQPPLGFGK
1510 1520 1530 1540 1550
LCPHRVACKR LVAMNVPLNS DGTVTFNATL FALVRTSLKI KTEGNLDQAN
1560 1570 1580 1590 1600
QELRMVIKKI WKRIKQKLLD EVIPPPDEEE VTVGKFYATF LIQDYFRKFR
1610 1620 1630 1640 1650
RRKEKGLLGR EAPTSTSSAL QAGLRSLQDL GPEIRQALTY DTEEEEEEEE
1660 1670 1680 1690 1700
AVGQEAEEEE AENNPEPYKD SIDSQPQSRW NSRISVSLPV KEKLPDSLST
1710 1720 1730 1740 1750
GPSDDDGLAP NSRQPSVIQA GSQPHRRSSG VFMFTIPEEG SIQLKGTQGQ
1760 1770 1780 1790 1800
DNQNEEQEVP DWTPDLDEQA GTPSNPVLLP PHWSQQHVNG HHVPRRRLLP
1810 1820 1830 1840 1850
PTPAGRKPSF TIQCLQRQGS CEDLPIPGTY HRGRTSGPSR AQGSWAAPPQ
1860 1870 1880 1890 1900
KGRLLYAPLL LVEESTVGEG YLGKLGGPLR TFTCLQVPGA HPNPSHRKRG
1910 1920 1930 1940 1950
SADSLVEAVL ISEGLGLFAQ DPRFVALAKQ EIADACHLTL DEMDSAASDL
1960 1970 1980
LAQRTTSLYS DEESILSRFD EEDLGDEMAC VHAL
Length:1,984
Mass (Da):221,827
Last modified:October 1, 2003 - v1
Checksum:iE193BF4CCBAD3882
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672231 Genomic DNA. No translation available.
AJ579852 mRNA. Translation: CAE30292.1.
RefSeqiNP_062528.2. NM_019582.2.
UniGeneiMm.289647.

Genome annotation databases

EnsembliENSMUST00000115726; ENSMUSP00000111391; ENSMUSG00000031142.
GeneIDi54652.
KEGGimmu:54652.
UCSCiuc009slp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672231 Genomic DNA. No translation available.
AJ579852 mRNA. Translation: CAE30292.1 .
RefSeqi NP_062528.2. NM_019582.2.
UniGenei Mm.289647.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 54652.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115726 ; ENSMUSP00000111391 ; ENSMUSG00000031142 .
GeneIDi 54652.
KEGGi mmu:54652.
UCSCi uc009slp.1. mouse.

Organism-specific databases

CTDi 778.
MGIi MGI:1859639. Cacna1f.

Phylogenomic databases

GeneTreei ENSGT00760000118827.
HOGENOMi HOG000231529.
HOVERGENi HBG050763.
KOi K04853.
OMAi AVKSTAC.
OrthoDBi EOG7T1RBQ.
TreeFami TF312805.

Miscellaneous databases

NextBioi 311512.
SOURCEi Search...

Gene expression databases

Genevestigatori Q7TNI3.

Family and domain databases

Gene3Di 1.20.120.350. 5 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina."
    Baumann L., Gerstner A., Zong X., Biel M., Wahl-Scott C.
    Invest. Ophthalmol. Vis. Sci. 45:708-713(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57Bl6Imported.
    Tissue: EyeImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ7TNI3_MOUSE
AccessioniPrimary (citable) accession number: Q7TNI3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3