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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Cacna1f

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1fImported
Synonyms:Cav1.4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei96 – 113HelicalSequence analysisAdd BLAST18
Transmembranei133 – 152HelicalSequence analysisAdd BLAST20
Transmembranei164 – 180HelicalSequence analysisAdd BLAST17
Transmembranei237 – 260HelicalSequence analysisAdd BLAST24
Transmembranei316 – 337HelicalSequence analysisAdd BLAST22
Transmembranei349 – 371HelicalSequence analysisAdd BLAST23
Transmembranei530 – 548HelicalSequence analysisAdd BLAST19
Transmembranei563 – 581HelicalSequence analysisAdd BLAST19
Transmembranei659 – 678HelicalSequence analysisAdd BLAST20
Transmembranei728 – 750HelicalSequence analysisAdd BLAST23
Transmembranei874 – 893HelicalSequence analysisAdd BLAST20
Transmembranei913 – 933HelicalSequence analysisAdd BLAST21
Transmembranei945 – 971HelicalSequence analysisAdd BLAST27
Transmembranei991 – 1020HelicalSequence analysisAdd BLAST30
Transmembranei1116 – 1143HelicalSequence analysisAdd BLAST28
Transmembranei1194 – 1215HelicalSequence analysisAdd BLAST22
Transmembranei1227 – 1246HelicalSequence analysisAdd BLAST20
Transmembranei1329 – 1347HelicalSequence analysisAdd BLAST19
Transmembranei1420 – 1444HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000031142.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1578 – 1612Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili807 – 830Sequence analysisAdd BLAST24
Coiled coili1642 – 1664Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04853.
OMAiDGHNAPR.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR030157. VDCC_L_a1F.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF184. PTHR10037:SF184. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESEVGKDT TPEPSPANGT GPGPEWGLCP GPPTVGTDTS GASGLGTPRR
60 70 80 90 100
RTQHNKHKTV AVASAQRSPR ALFCLTLTNP IRRSCISIVE WKPFDILILL
110 120 130 140 150
TIFANCVALG VYIPFPEDDS NTANHNLEQV EYVFLVIFTV ETVLKIVAYG
160 170 180 190 200
LVLHPSAYIR NGWNLLDFII VVVGLFSVLL EQGPGRPGDA PHTGGKPGGF
210 220 230 240 250
DVKALRAFRV LRPLRLVSGV PSLHIVLNSI MKALVPLLHI ALLVLFVIII
260 270 280 290 300
YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR SCTLNHTECR
310 320 330 340 350
GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV
360 370 380 390 400
YFVSLVIFGS FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQMEED
410 420 430 440 450
LRGYLDWITQ AEELDLHDPS VDGNLASLAE EGRAGHRPQL SELTNRRRGR
460 470 480 490 500
LRWFSHSTRS THSTSSHASL PASDTGSMTD TPGDEDEEEG TMASCTRCLN
510 520 530 540 550
KIMKTRICRH FRRANRGLRA RCRRAVKSNA CYWAVLLLVF LNTLTIASEH
560 570 580 590 600
HGQPLWLTQT QEYANKVLLC LFTVEMLLKL YGLGPSVYVA SFFNRFDCFV
610 620 630 640 650
VCGGILETTL VEVGAMQPLG ISVLRCVRLL RIFKVTRHWA SLSNLVASLL
660 670 680 690 700
NSMKSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDQTHTK RSTFDTFPQA
710 720 730 740 750
LLTVFQILTG EDWNVVMYDG IMAYGGPFFP GMLVCVYFII LFICGNYILL
760 770 780 790 800
NVFLAIAVDN LASGDAGTAK DKGREKSSEG NPPKENKVLV PGGENEDAKG
810 820 830 840 850
ARSEGAAPGM EEEEEEEEEE EEEEEEENGA GHVELLQEVV PKEKVVPIPE
860 870 880 890 900
GSAFFCLSQT NPLRKACHTL IHHHIFTSLI LVFIILSSVS LAAEDPIRAH
910 920 930 940 950
SFRNHILGYF DYAFTSIFTV EILLKMTVFG AFLHRGSFCR SWFNLLDLLV
960 970 980 990 1000
VSVSLISFGI HSSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI
1010 1020 1030 1040 1050
RTIGNIMIVT TLLQFMFACI GVQLFKGKFY SCTDEAKHTL KECKGSFLIY
1060 1070 1080 1090 1100
PDGDVSRPLV RERLWVNSDF NFDNVLSAMM ALFTVSTFEG WPALLYKAID
1110 1120 1130 1140 1150
ANAEDEGPIY NYHVEISVFF IVYIIIIAFF MMNIFVGFVI ITFRAQGEQE
1160 1170 1180 1190 1200
YQNCELDKNQ RQCVEYALKA QPLRRYIPKN PHQYRVWATV NSAAFEYLMF
1210 1220 1230 1240 1250
LLILLNTVAL AMQHYEQTAP FNYAMDILNM VFTGLFTIEM VLKIIAFKPK
1260 1270 1280 1290 1300
HYFADAWNTF DALIVVGSVV DIAVTEVNNG GHLGESSEDS SRISITFFRL
1310 1320 1330 1340 1350
FRVMRLVKLL SKGEGIRTLL WTFIKSFQAL PYVALLIAMI FFIYAVIGMQ
1360 1370 1380 1390 1400
MFGKVALQDG TQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLASLPGNR
1410 1420 1430 1440 1450
CDPESDFGPG EEFTCGSSFA IVYFISFFML CAFLIINLFV AVIMDNFDYL
1460 1470 1480 1490 1500
TRDWSILGPH HLDEFKRIWS EYDPGAKGRI KHLDVVALLR RIQPPLGFGK
1510 1520 1530 1540 1550
LCPHRVACKR LVAMNVPLNS DGTVTFNATL FALVRTSLKI KTEGNLDQAN
1560 1570 1580 1590 1600
QELRMVIKKI WKRIKQKLLD EVIPPPDEEE VTVGKFYATF LIQDYFRKFR
1610 1620 1630 1640 1650
RRKEKGLLGR EAPTSTSSAL QAGLRSLQDL GPEIRQALTY DTEEEEEEEE
1660 1670 1680 1690 1700
AVGQEAEEEE AENNPEPYKD SIDSQPQSRW NSRISVSLPV KEKLPDSLST
1710 1720 1730 1740 1750
GPSDDDGLAP NSRQPSVIQA GSQPHRRSSG VFMFTIPEEG SIQLKGTQGQ
1760 1770 1780 1790 1800
DNQNEEQEVP DWTPDLDEQA GTPSNPVLLP PHWSQQHVNG HHVPRRRLLP
1810 1820 1830 1840 1850
PTPAGRKPSF TIQCLQRQGS CEDLPIPGTY HRGRTSGPSR AQGSWAAPPQ
1860 1870 1880 1890 1900
KGRLLYAPLL LVEESTVGEG YLGKLGGPLR TFTCLQVPGA HPNPSHRKRG
1910 1920 1930 1940 1950
SADSLVEAVL ISEGLGLFAQ DPRFVALAKQ EIADACHLTL DEMDSAASDL
1960 1970 1980
LAQRTTSLYS DEESILSRFD EEDLGDEMAC VHAL
Length:1,984
Mass (Da):221,827
Last modified:October 1, 2003 - v1
Checksum:iE193BF4CCBAD3882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672231 Genomic DNA. No translation available.
AJ579852 mRNA. Translation: CAE30292.1.
RefSeqiNP_062528.2. NM_019582.2.
UniGeneiMm.289647.

Genome annotation databases

EnsembliENSMUST00000115726; ENSMUSP00000111391; ENSMUSG00000031142.
GeneIDi54652.
KEGGimmu:54652.
UCSCiuc009slp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672231 Genomic DNA. No translation available.
AJ579852 mRNA. Translation: CAE30292.1.
RefSeqiNP_062528.2. NM_019582.2.
UniGeneiMm.289647.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111391.

Protocols and materials databases

DNASUi54652.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115726; ENSMUSP00000111391; ENSMUSG00000031142.
GeneIDi54652.
KEGGimmu:54652.
UCSCiuc009slp.1. mouse.

Organism-specific databases

CTDi778.
MGIiMGI:1859639. Cacna1f.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04853.
OMAiDGHNAPR.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031142.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR030157. VDCC_L_a1F.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF184. PTHR10037:SF184. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TNI3_MOUSE
AccessioniPrimary (citable) accession number: Q7TNI3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.