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Protein

Probable D-lactate dehydrogenase, mitochondrial

Gene

Ldhd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+.

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

  • ATP biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-lactate dehydrogenase, mitochondrial (EC:1.1.2.4)
Short name:
DLD
Short name:
Lactate dehydrogenase D
Gene namesi
Name:LdhdImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106428 Ldhd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000262953? – 484Probable D-lactate dehydrogenase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36N6-acetyllysineCombined sources1
Modified residuei292N6-acetyllysineCombined sources1
Modified residuei335N6-acetyllysine; alternateCombined sources1
Modified residuei335N6-succinyllysine; alternateCombined sources1
Modified residuei422N6-acetyllysineCombined sources1
Modified residuei449N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7TNG8
PaxDbiQ7TNG8
PeptideAtlasiQ7TNG8
PRIDEiQ7TNG8

PTM databases

iPTMnetiQ7TNG8
PhosphoSitePlusiQ7TNG8
SwissPalmiQ7TNG8

Expressioni

Tissue specificityi

Readily detected in liver and kidney, with a weaker signal observed in heart, skeletal muscle, stomach, brain, and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000031958
CleanExiMM_LDHD
GenevisibleiQ7TNG8 MM

Interactioni

Subunit structurei

Interacts with CSRP3.1 Publication

Protein-protein interaction databases

IntActiQ7TNG8, 2 interactors
MINTiQ7TNG8
STRINGi10090.ENSMUSP00000068086

Structurei

3D structure databases

ProteinModelPortaliQ7TNG8
SMRiQ7TNG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 242FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1231 Eukaryota
COG0277 LUCA
GeneTreeiENSGT00530000063515
HOGENOMiHOG000230995
HOVERGENiHBG066407
InParanoidiQ7TNG8
KOiK00102
OMAiTPRTCGE
OrthoDBiEOG091G0BAW
PhylomeDBiQ7TNG8
TreeFamiTF314122

Family and domain databases

Gene3Di1.10.45.10, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016164 FAD-linked_Oxase-like_C
IPR004113 FAD-linked_oxidase_C
IPR006094 Oxid_FAD_bind_N
IPR016171 Vanillyl_alc_oxidase_C-sub2
PfamiView protein in Pfam
PF02913 FAD-oxidase_C, 1 hit
PF01565 FAD_binding_4, 1 hit
SUPFAMiSSF55103 SSF55103, 1 hit
SSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLLRVATQ RLSPWRSFCS RGSQGGLSQD FVEALKAVVG SPHVSTASAV
60 70 80 90 100
REQHGHDESM HRCQPPDAVV WPQNVDQVSR VASLCYNQGV PIIPFGTGTG
110 120 130 140 150
VEGGVCAVQG GVCINLTHMD QITELNTEDF SVVVEPGVTR KALNTHLRDS
160 170 180 190 200
GLWFPVDPGA DASLCGMAAT GASGTNAVRY GTMRDNVINL EVVLPDGRLL
210 220 230 240 250
HTAGRGRHYR KSAAGYNLTG LFVGSEGTLG IITSTTLRLH PAPEATVAAT
260 270 280 290 300
CAFPSVQAAV DSTVQILQAA VPVARIEFLD DVMMDACNRH SKLNCPVAPT
310 320 330 340 350
LFLEFHGSQQ TLAEQLQRTE AITQDNGGSH FSWAKEAEKR NELWAARHNA
360 370 380 390 400
WYAALALSPG SKAYSTDVCV PISRLPEILV ETKEEIKASK LTGAIVGHVG
410 420 430 440 450
DGNFHCILLV DPDDAEEQRR VKAFAENLGR RALALGGTCT GEHGIGLGKR
460 470 480
QLLQEEVGPV GVETMRQLKN TLDPRGLMNP GKVL
Length:484
Mass (Da):51,848
Last modified:October 1, 2003 - v1
Checksum:i78BDF31A861B9A82
GO

Sequence cautioni

The sequence AAM50323 differs from that shown. Reason: Frameshift at positions 459 and 474.Curated
The sequence BAC29917 differs from that shown. Reason: Frameshift at positions 141, 229 and 315.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti413D → H in BAC29917 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY092768 mRNA Translation: AAM50323.1 Frameshift.
BC039155 mRNA Translation: AAH39155.1
BC055443 mRNA Translation: AAH55443.1
AK037996 mRNA Translation: BAC29917.1 Frameshift.
CCDSiCCDS22677.1
RefSeqiNP_081846.3, NM_027570.3
UniGeneiMm.271578
Mm.27589

Genome annotation databases

EnsembliENSMUST00000070004; ENSMUSP00000068086; ENSMUSG00000031958
GeneIDi52815
KEGGimmu:52815
UCSCiuc009nmn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLDHD_MOUSE
AccessioniPrimary (citable) accession number: Q7TNG8
Secondary accession number(s): Q8BYU7, Q8CIV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health