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Protein

Echinoderm microtubule-associated protein-like 2

Gene

Eml2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 2
Short name:
EMAP-2
Gene namesi
Name:Eml2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919455 Eml2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843881 – 649Echinoderm microtubule-associated protein-like 2Add BLAST649

Proteomic databases

EPDiQ7TNG5
PaxDbiQ7TNG5
PeptideAtlasiQ7TNG5
PRIDEiQ7TNG5

PTM databases

iPTMnetiQ7TNG5
PhosphoSitePlusiQ7TNG5

Expressioni

Gene expression databases

BgeeiENSMUSG00000040811
CleanExiMM_EML2
ExpressionAtlasiQ7TNG5 baseline and differential
GenevisibleiQ7TNG5 MM

Interactioni

Subunit structurei

Binds unpolymerized tubulins via its WD repeat region. Interacts with GRID2 and may also interact with GRID1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7TNG5, 1 interactor
MINTiQ7TNG5
STRINGi10090.ENSMUSP00000037654

Structurei

3D structure databases

ProteinModelPortaliQ7TNG5
SMRiQ7TNG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 93WD 1Add BLAST38
Repeati97 – 144WD 2Add BLAST48
Repeati151 – 192WD 3Add BLAST42
Repeati195 – 234WD 4Add BLAST40
Repeati241 – 280WD 5Add BLAST40
Repeati285 – 323WD 6Add BLAST39
Repeati369 – 406WD 7Add BLAST38
Repeati410 – 447WD 8Add BLAST38
Repeati452 – 489WD 9Add BLAST38
Repeati495 – 535WD 10Add BLAST41
Repeati564 – 602WD 11Add BLAST39
Repeati609 – 648WD 12Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 649Tandem atypical propeller in EMLsBy similarityAdd BLAST640

Domaini

Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).By similarity

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106 Eukaryota
ENOG410XNTQ LUCA
GeneTreeiENSGT00550000074369
HOGENOMiHOG000294061
HOVERGENiHBG051470
InParanoidiQ7TNG5
KOiK18595
TreeFamiTF317832

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF03451 HELP, 1 hit
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50998 SSF50998, 5 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TNG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSFGIGKTK EVIFSMEEGS VKMFLRGRPV PMLIPDELAP TYSLDTRSEL
60 70 80 90 100
PSSRLKLDWV YGYRGRDCRA NLYLLPTGEV VYFVASVAVL YSVEEQRQRH
110 120 130 140 150
YLGHNDDIKC LAVHPDMVTI ATGQVAGTTK EGKPLPPHVR VWDSVSLSTL
160 170 180 190 200
HVLGLGVFDR AVCCVAFSKS NGGNLLCAVD ESNDHVLSVW DWAKESKVVD
210 220 230 240 250
SKCSNEAVLV ATFHPTDPSL LITCGKSHIY FWSLEGGSLS KRQGLFEKHE
260 270 280 290 300
KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQEVQ GAHDGGVFAL
310 320 330 340 350
CALRDGTLVS GGGRDRRVVL WGSDYSKVQE VEVPEDFGPV RTVAEGRGDT
360 370 380 390 400
LYVGTTRNSI LLGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL
410 420 430 440 450
VHLWSSETHQ PVWSRSIEDP ARSAGFHPSG SVLAVGTVTG RWLLLDTETH
460 470 480 490 500
DLVAIHTDGN EQISVVSFSP DGAYLAVGSH DNLVYVYTVD QGGRKVSRLG
510 520 530 540 550
KCSGHSSFIT HLDWAQDSTC FVTNSGDYEI LYWDPVTCKQ ITSADTVRNV
560 570 580 590 600
EWATATCVLG FGVFGIWPEG ADGTDINAVA RSHDGKLLVS ADDFGKVHLF
610 620 630 640
SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVA
Length:649
Mass (Da):70,734
Last modified:October 1, 2003 - v1
Checksum:i7B85AE89FE9ECAAC
GO
Isoform 2 (identifier: Q7TNG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: Y → YPLTSSLSALLEEALGFSSY

Note: No experimental confirmation available.
Show »
Length:668
Mass (Da):72,701
Checksum:iD81FF853F3E7665D
GO

Sequence cautioni

The sequence BAB24122 differs from that shown. Reason: Frameshift at position 32.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251K → R in BAB24122 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02448061Y → YPLTSSLSALLEEALGFSSY in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005562 mRNA Translation: BAB24122.1 Frameshift.
BC055476 mRNA Translation: AAH55476.1
CCDSiCCDS52055.1 [Q7TNG5-2]
CCDS85224.1 [Q7TNG5-1]
RefSeqiNP_001156468.1, NM_001162996.1 [Q7TNG5-1]
NP_082429.1, NM_028153.1 [Q7TNG5-2]
UniGeneiMm.154121

Genome annotation databases

EnsembliENSMUST00000048502; ENSMUSP00000037654; ENSMUSG00000040811 [Q7TNG5-2]
ENSMUST00000120595; ENSMUSP00000112447; ENSMUSG00000040811 [Q7TNG5-1]
GeneIDi72205
KEGGimmu:72205
UCSCiuc009fkz.2 mouse [Q7TNG5-1]
uc009fla.2 mouse [Q7TNG5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEMAL2_MOUSE
AccessioniPrimary (citable) accession number: Q7TNG5
Secondary accession number(s): Q9DAS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health