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Q7TNF4

- Q7TNF4_MOUSE

UniProt

Q7TNF4 - Q7TNF4_MOUSE

Protein
Submitted name:

Kinesin light chain 1

Gene

Klc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. microtubule motor activity Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. axon cargo transport Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Kinesin light chain 1Imported
    Gene namesi
    Name:Klc1Imported
    Synonyms:Kns2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:107978. Klc1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. ciliary rootlet Source: MGI
    3. cytoplasm Source: MGI
    4. cytoplasmic vesicle Source: MGI
    5. kinesin complex Source: InterPro
    6. membrane-bounded organelle Source: MGI
    7. neuron projection Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TNF4.

    Family & Domainsi

    Keywords - Domaini

    RepeatUniRule annotation, TPR repeatUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000006393.
    HOGENOMiHOG000261663.
    HOVERGENiHBG006217.
    KOiK10407.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR002151. Kinesin_light.
    IPR015792. Kinesin_light_repeat.
    IPR015390. Rabaptin_Rab5-bd_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF09311. Rab5-bind. 1 hit.
    PF00515. TPR_1. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    PRINTSiPR00381. KINESINLIGHT.
    SMARTiSM00028. TPR. 5 hits.
    [Graphical view]
    PROSITEiPS01160. KINESIN_LIGHT. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TNF4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDNMSTMVY IKEEKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL    50
    ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE 100
    SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF 150
    MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDEPGQG IQQQHSSAAA 200
    AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD 250
    HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG RDHPAVAATL 300
    NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ 350
    NQGKYEEVEY YYQRALGIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA 400
    ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGSAFGEYG 450
    GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA MRSRKQRVAE 500
    VLNDPESMEK RRSRESLNMD VVKYESGPDG GEEVSMSVEW NGDGTGSLKR 550
    SGSFSKLRAS IRRSSEKLVR KLKGGSSRDS EPRNPGASPA EPLCVENDSS 600
    SLEDASTN 608
    Length:608
    Mass (Da):68,603
    Last modified:October 1, 2003 - v1
    Checksum:i328BA2D5E5BDDC6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152065 Genomic DNA. No translation available.
    BC055744 mRNA. Translation: AAH55744.1.
    RefSeqiNP_001075428.1. NM_001081959.1.
    NP_032476.2. NM_008450.2.
    UniGeneiMm.278357.

    Genome annotation databases

    EnsembliENSMUST00000122300; ENSMUSP00000113997; ENSMUSG00000021288.
    GeneIDi16593.
    KEGGimmu:16593.
    UCSCiuc007pdw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152065 Genomic DNA. No translation available.
    BC055744 mRNA. Translation: AAH55744.1 .
    RefSeqi NP_001075428.1. NM_001081959.1.
    NP_032476.2. NM_008450.2.
    UniGenei Mm.278357.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000122300 ; ENSMUSP00000113997 ; ENSMUSG00000021288 .
    GeneIDi 16593.
    KEGGi mmu:16593.
    UCSCi uc007pdw.1. mouse.

    Organism-specific databases

    CTDi 3831.
    MGIi MGI:107978. Klc1.

    Phylogenomic databases

    GeneTreei ENSGT00390000006393.
    HOGENOMi HOG000261663.
    HOVERGENi HBG006217.
    KOi K10407.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Miscellaneous databases

    ChiTaRSi KLC1. mouse.
    NextBioi 290149.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q7TNF4.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR002151. Kinesin_light.
    IPR015792. Kinesin_light_repeat.
    IPR015390. Rabaptin_Rab5-bd_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF09311. Rab5-bind. 1 hit.
    PF00515. TPR_1. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00381. KINESINLIGHT.
    SMARTi SM00028. TPR. 5 hits.
    [Graphical view ]
    PROSITEi PS01160. KINESIN_LIGHT. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    2. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ7TNF4_MOUSE
    AccessioniPrimary (citable) accession number: Q7TNF4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3