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Protein

Ribosome production factor 1

Gene

Rpf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be required for ribosome biogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 1
Alternative name(s):
Brix domain-containing protein 5
Ribosome biogenesis protein RPF1
Gene namesi
Name:Rpf1
Synonyms:Bxdc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917535. Rpf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Ribosome production factor 1PRO_0000120249Add
BLAST

Proteomic databases

EPDiQ7TND5.
MaxQBiQ7TND5.
PaxDbiQ7TND5.
PeptideAtlasiQ7TND5.
PRIDEiQ7TND5.

PTM databases

iPTMnetiQ7TND5.
PhosphoSiteiQ7TND5.

Expressioni

Gene expression databases

BgeeiQ7TND5.
CleanExiMM_BXDC5.
ExpressionAtlasiQ7TND5. baseline and differential.
GenevisibleiQ7TND5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ7TND5. 1 interaction.
MINTiMINT-4607434.
STRINGi10090.ENSMUSP00000029838.

Structurei

3D structure databases

ProteinModelPortaliQ7TND5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 325184BrixPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni303 – 32018RNA-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2780. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074691.
HOGENOMiHOG000172062.
HOVERGENiHBG083559.
InParanoidiQ7TND5.
KOiK14846.
OMAiTDEFAPY.
OrthoDBiEOG754HPR.
PhylomeDBiQ7TND5.
TreeFamiTF105897.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TND5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAGEKSVG GGKRGLKRKA AAEEPQEAAA ASDGTAESGV QPAKAAAFPP
60 70 80 90 100
GFSISEIKNK QRRHLMFTRW KQQQRKEKLA AKKKLKKERE ALGDKAPPKP
110 120 130 140 150
VPKTIDNQRV YDETTVDPND EEVAYDEATD EFASYFNRQT SPKILITTSD
160 170 180 190 200
RPHGRTVRLC EQLSTVIPDS HVYYRRGLAL KKIIPQCIAR DFTDLIVINE
210 220 230 240 250
DRKTPNGLIL SHLPNGPTAH FKMSSVRLRK EIKRRGKDPT EHVPEIILNN
260 270 280 290 300
FTTRLGHSIG RMFASLFPHN PQFIGRQVAT FHNQRDYIFF RFHRYIFKSE
310 320 330 340
KKVGIQELGP RFTLKLRSLQ KGTFDSKYGE YEWVHKPREM DTSRRKFHL
Length:349
Mass (Da):40,037
Last modified:July 19, 2005 - v2
Checksum:i9E044A2C04E32F77
GO

Sequence cautioni

The sequence AAH28802.1 differs from that shown.Intron retention.Curated
The sequence AAH56165.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH89369.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471A → V in BAE42233 (PubMed:16141072).Curated
Sequence conflicti299 – 2991S → G in BAE42233 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK171079 mRNA. Translation: BAE42233.1.
BC028802 mRNA. Translation: AAH28802.1. Sequence problems.
BC056165 mRNA. Translation: AAH56165.2. Different initiation.
BC089369 mRNA. Translation: AAH89369.2. Different initiation.
CCDSiCCDS51089.1.
RefSeqiNP_081608.1. NM_027332.3.
NP_081647.2. NM_027371.3.
UniGeneiMm.28128.

Genome annotation databases

EnsembliENSMUST00000029838; ENSMUSP00000029838; ENSMUSG00000028187.
GeneIDi70285.
KEGGimmu:70285.
UCSCiuc008rrl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK171079 mRNA. Translation: BAE42233.1.
BC028802 mRNA. Translation: AAH28802.1. Sequence problems.
BC056165 mRNA. Translation: AAH56165.2. Different initiation.
BC089369 mRNA. Translation: AAH89369.2. Different initiation.
CCDSiCCDS51089.1.
RefSeqiNP_081608.1. NM_027332.3.
NP_081647.2. NM_027371.3.
UniGeneiMm.28128.

3D structure databases

ProteinModelPortaliQ7TND5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TND5. 1 interaction.
MINTiMINT-4607434.
STRINGi10090.ENSMUSP00000029838.

PTM databases

iPTMnetiQ7TND5.
PhosphoSiteiQ7TND5.

Proteomic databases

EPDiQ7TND5.
MaxQBiQ7TND5.
PaxDbiQ7TND5.
PeptideAtlasiQ7TND5.
PRIDEiQ7TND5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029838; ENSMUSP00000029838; ENSMUSG00000028187.
GeneIDi70285.
KEGGimmu:70285.
UCSCiuc008rrl.2. mouse.

Organism-specific databases

CTDi80135.
MGIiMGI:1917535. Rpf1.

Phylogenomic databases

eggNOGiKOG2780. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074691.
HOGENOMiHOG000172062.
HOVERGENiHBG083559.
InParanoidiQ7TND5.
KOiK14846.
OMAiTDEFAPY.
OrthoDBiEOG754HPR.
PhylomeDBiQ7TND5.
TreeFamiTF105897.

Miscellaneous databases

ChiTaRSiRpf1. mouse.
PROiQ7TND5.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TND5.
CleanExiMM_BXDC5.
ExpressionAtlasiQ7TND5. baseline and differential.
GenevisibleiQ7TND5. MM.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Dendritic cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain, Eye and Mammary gland.

Entry informationi

Entry nameiRPF1_MOUSE
AccessioniPrimary (citable) accession number: Q7TND5
Secondary accession number(s): Q3TBS4, Q5EBN9, Q8K343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 6, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.