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Protein

Putative RNA-binding protein Luc7-like 2

Gene

Luc7l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 2
Alternative name(s):
CGI-74 homolog
Gene namesi
Name:Luc7l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2183260. Luc7l2.

Subcellular locationi

Isoform 4 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Putative RNA-binding protein Luc7-like 2PRO_0000187283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei266 – 26615-hydroxylysine; by JMJD6By similarity
Modified residuei269 – 26915-hydroxylysine; by JMJD6By similarity

Keywords - PTMi

Hydroxylation, Phosphoprotein

Proteomic databases

EPDiQ7TNC4.
MaxQBiQ7TNC4.
PaxDbiQ7TNC4.
PRIDEiQ7TNC4.

PTM databases

iPTMnetiQ7TNC4.
PhosphoSiteiQ7TNC4.

Expressioni

Tissue specificityi

All isoforms are expressed in brain, kidney, heart, thymus, stomach, skeletal muscle, testis and spinal cord.1 Publication

Gene expression databases

BgeeiQ7TNC4.
CleanExiMM_LUC7L2.
ExpressionAtlasiQ7TNC4. baseline and differential.
GenevisibleiQ7TNC4. MM.

Interactioni

Subunit structurei

Interacts with SCNM1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228673. 2 interactions.
IntActiQ7TNC4. 4 interactions.
MINTiMINT-1605815.
STRINGi10090.ENSMUSP00000055254.

Structurei

3D structure databases

ProteinModelPortaliQ7TNC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili102 – 17776Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi239 – 387149Arg/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ7TNC4.
KOiK13212.
OMAiDQDFFFE.
PhylomeDBiQ7TNC4.
TreeFamiTF317607.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TNC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVSKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASRDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Length:392
Mass (Da):46,583
Last modified:October 1, 2003 - v1
Checksum:i1A5202B1F537A7CC
GO
Isoform 2 (identifier: Q7TNC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-269: Missing.
     335-335: S → Y
     336-392: Missing.

Show »
Length:325
Mass (Da):38,611
Checksum:i5C8AC61980E5D16D
GO
Isoform 3 (identifier: Q7TNC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: S → Y
     336-392: Missing.

Show »
Length:335
Mass (Da):39,790
Checksum:i6184B722DCEDA297
GO
Isoform 4 (identifier: Q7TNC4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-269: Missing.

Show »
Length:382
Mass (Da):45,405
Checksum:i34D02E7A1679AB98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471G → E in AAH56383 (PubMed:15489334).Curated
Sequence conflicti245 – 2451K → L in AAK01182 (Ref. 1) Curated
Sequence conflicti259 – 2591R → W in AAK01182 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei260 – 26910Missing in isoform 2 and isoform 4. 1 PublicationVSP_010218
Alternative sequencei335 – 3351S → Y in isoform 2 and isoform 3. 1 PublicationVSP_010219
Alternative sequencei336 – 39257Missing in isoform 2 and isoform 3. 1 PublicationVSP_010220Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318301 mRNA. Translation: AAK01182.1.
BC002314 mRNA. Translation: AAH02314.1.
BC056354 mRNA. Translation: AAH56354.1.
BC056383 mRNA. Translation: AAH56383.1.
BC056970 mRNA. Translation: AAH56970.1.
CCDSiCCDS20015.1. [Q7TNC4-1]
CCDS51751.1. [Q7TNC4-2]
RefSeqiNP_001164320.1. NM_001170849.1. [Q7TNC4-2]
NP_001298028.1. NM_001311099.1.
NP_001298029.1. NM_001311100.1.
NP_619621.2. NM_138680.2. [Q7TNC4-1]
UniGeneiMm.276133.
Mm.479854.
Mm.482221.

Genome annotation databases

EnsembliENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823. [Q7TNC4-1]
ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823. [Q7TNC4-2]
GeneIDi192196.
KEGGimmu:192196.
UCSCiuc009bkl.2. mouse. [Q7TNC4-2]
uc009bkm.2. mouse. [Q7TNC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318301 mRNA. Translation: AAK01182.1.
BC002314 mRNA. Translation: AAH02314.1.
BC056354 mRNA. Translation: AAH56354.1.
BC056383 mRNA. Translation: AAH56383.1.
BC056970 mRNA. Translation: AAH56970.1.
CCDSiCCDS20015.1. [Q7TNC4-1]
CCDS51751.1. [Q7TNC4-2]
RefSeqiNP_001164320.1. NM_001170849.1. [Q7TNC4-2]
NP_001298028.1. NM_001311099.1.
NP_001298029.1. NM_001311100.1.
NP_619621.2. NM_138680.2. [Q7TNC4-1]
UniGeneiMm.276133.
Mm.479854.
Mm.482221.

3D structure databases

ProteinModelPortaliQ7TNC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228673. 2 interactions.
IntActiQ7TNC4. 4 interactions.
MINTiMINT-1605815.
STRINGi10090.ENSMUSP00000055254.

PTM databases

iPTMnetiQ7TNC4.
PhosphoSiteiQ7TNC4.

Proteomic databases

EPDiQ7TNC4.
MaxQBiQ7TNC4.
PaxDbiQ7TNC4.
PRIDEiQ7TNC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823. [Q7TNC4-1]
ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823. [Q7TNC4-2]
GeneIDi192196.
KEGGimmu:192196.
UCSCiuc009bkl.2. mouse. [Q7TNC4-2]
uc009bkm.2. mouse. [Q7TNC4-1]

Organism-specific databases

CTDi51631.
MGIiMGI:2183260. Luc7l2.

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ7TNC4.
KOiK13212.
OMAiDQDFFFE.
PhylomeDBiQ7TNC4.
TreeFamiTF317607.

Miscellaneous databases

ChiTaRSiLuc7l2. mouse.
PROiQ7TNC4.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TNC4.
CleanExiMM_LUC7L2.
ExpressionAtlasiQ7TNC4. baseline and differential.
GenevisibleiQ7TNC4. MM.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CGI-74 homolog in the mouse."
    Utsch B., Albers N., Wickert L., Schubert R., Bidlingmaier F., Ludwig M.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: NMRI.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-392 (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Evidence for a direct role of the disease modifier SCNM1 in splicing."
    Howell V.M., Jones J.M., Bergren S.K., Li L., Billi A.C., Avenarius M.R., Meisler M.H.
    Hum. Mol. Genet. 16:2506-2516(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-311 (ISOFORMS 1/2/3/4), INTERACTION WITH SCNM1, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Embryo.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLC7L2_MOUSE
AccessioniPrimary (citable) accession number: Q7TNC4
Secondary accession number(s): Q99LM5, Q99PC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.