ID   TNNT1_RAT               Reviewed;         261 AA.
AC   Q7TNB2; Q7TNA9; Q7TNB0; Q7TNB1; Q923S7;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   24-JAN-2024, entry version 122.
DE   RecName: Full=Troponin T, slow skeletal muscle;
DE            Short=TnTs;
DE   AltName: Full=Slow skeletal muscle troponin T;
DE            Short=sTnT;
GN   Name=Tnnt1; Synonyms=Fang2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=Wistar;
RX   PubMed=15788488; DOI=10.1152/ajpcell.00365.2004;
RA   Kischel P., Bastide B., Muller M., Dubail F., Offredi F., Jin J.-P.,
RA   Mounier Y., Martial J.;
RT   "Expression and functional properties of four slow skeletal troponin T
RT   isoforms in rat muscles.";
RL   Am. J. Physiol. 289:C437-C443(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=Sprague-Dawley;
RA   Chang Y.Y., Zuo J.J., Fang F.F.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC   -!- SUBUNIT: Interacts with TPM3. {ECO:0000250|UniProtKB:P13805}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=sTnT1;
CC         IsoId=Q7TNB2-1; Sequence=Displayed;
CC       Name=2; Synonyms=sTnT2;
CC         IsoId=Q7TNB2-2; Sequence=VSP_013790;
CC       Name=3; Synonyms=sTnT3;
CC         IsoId=Q7TNB2-3; Sequence=VSP_013789, VSP_013790;
CC       Name=4; Synonyms=sTnTx;
CC         IsoId=Q7TNB2-4; Sequence=VSP_013789;
CC   -!- TISSUE SPECIFICITY: Expressed in soleus muscle. Isoform 4 is
CC       predominantly expressed in fast muscles. {ECO:0000269|PubMed:15788488}.
CC   -!- MISCELLANEOUS: [Isoform 1]: Major.
CC   -!- MISCELLANEOUS: [Isoform 2]: Major. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform 3]: Minor. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform 4]: Minor. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK94010.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY334079; AAQ19259.1; -; mRNA.
DR   EMBL; AY334080; AAQ19260.1; -; mRNA.
DR   EMBL; AY334081; AAQ19261.1; -; mRNA.
DR   EMBL; AY334082; AAQ19262.1; -; mRNA.
DR   EMBL; AF399874; AAK94010.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001264189.1; NM_001277260.1. [Q7TNB2-2]
DR   RefSeq; NP_001264190.1; NM_001277261.2. [Q7TNB2-3]
DR   RefSeq; NP_001264191.1; NM_001277262.2. [Q7TNB2-4]
DR   RefSeq; NP_599215.2; NM_134388.2. [Q7TNB2-1]
DR   AlphaFoldDB; Q7TNB2; -.
DR   SMR; Q7TNB2; -.
DR   STRING; 10116.ENSRNOP00000038327; -.
DR   iPTMnet; Q7TNB2; -.
DR   PhosphoSitePlus; Q7TNB2; -.
DR   jPOST; Q7TNB2; -.
DR   PaxDb; 10116-ENSRNOP00000038327; -.
DR   Ensembl; ENSRNOT00000034957.7; ENSRNOP00000038327.4; ENSRNOG00000028041.8. [Q7TNB2-1]
DR   Ensembl; ENSRNOT00000058843.6; ENSRNOP00000055633.4; ENSRNOG00000028041.8. [Q7TNB2-4]
DR   Ensembl; ENSRNOT00055026943; ENSRNOP00055021776; ENSRNOG00055015790. [Q7TNB2-1]
DR   Ensembl; ENSRNOT00060047448; ENSRNOP00060039497; ENSRNOG00060027201. [Q7TNB2-1]
DR   Ensembl; ENSRNOT00065055968; ENSRNOP00065046098; ENSRNOG00065032525. [Q7TNB2-1]
DR   GeneID; 171409; -.
DR   KEGG; rno:171409; -.
DR   UCSC; RGD:621852; rat. [Q7TNB2-1]
DR   AGR; RGD:621852; -.
DR   CTD; 7138; -.
DR   RGD; 621852; Tnnt1.
DR   eggNOG; KOG3634; Eukaryota.
DR   GeneTree; ENSGT00940000160609; -.
DR   InParanoid; Q7TNB2; -.
DR   OMA; EWIYELE; -.
DR   OrthoDB; 5362548at2759; -.
DR   PhylomeDB; Q7TNB2; -.
DR   Reactome; R-RNO-390522; Striated Muscle Contraction.
DR   PRO; PR:Q7TNB2; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000028041; Expressed in esophagus and 17 other cell types or tissues.
DR   GO; GO:0005861; C:troponin complex; IDA:RGD.
DR   GO; GO:0005523; F:tropomyosin binding; ISO:RGD.
DR   GO; GO:0031014; F:troponin T binding; IDA:RGD.
DR   GO; GO:0045932; P:negative regulation of muscle contraction; ISO:RGD.
DR   GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR   GO; GO:0003009; P:skeletal muscle contraction; ISO:RGD.
DR   GO; GO:0031444; P:slow-twitch skeletal muscle fiber contraction; IDA:RGD.
DR   GO; GO:0014883; P:transition between fast and slow fiber; ISO:RGD.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; TROPONIN T; 1.
DR   PANTHER; PTHR11521:SF6; TROPONIN T, SLOW SKELETAL MUSCLE; 1.
DR   Pfam; PF00992; Troponin; 2.
DR   SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
DR   Genevisible; Q7TNB2; RN.
PE   1: Evidence at protein level;
KW   Alternative splicing; Muscle protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..261
FT                   /note="Troponin T, slow skeletal muscle"
FT                   /id="PRO_0000186171"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         24..34
FT                   /note="Missing (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15788488"
FT                   /id="VSP_013789"
FT   VAR_SEQ         35
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15788488"
FT                   /id="VSP_013790"
SQ   SEQUENCE   261 AA;  31215 MW;  B323364DBCAB5863 CRC64;
     MSDTEEQEYE EEQAEDEEAV EEEAPEEPEP VAEREEERPK PSRPVVPPLI PPKIPEGERV
     DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD RIERRRAERA EQQRFRTEKE
     RERQAKLAEE KMRKEEEEAK KRAEDDAKKK KVLSNMGAHF GGYLVKAEQK RGKRQTGREM
     KLRILSERKK PLNIDYMGED QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR
     ISHAQKFRKG AGKGRVGGRW K
//