Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Troponin T, slow skeletal muscle

Gene

Tnnt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  1. troponin T binding Source: RGD

GO - Biological processi

  1. negative regulation of muscle contraction Source: Ensembl
  2. regulation of muscle contraction Source: RGD
  3. slow-twitch skeletal muscle fiber contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Enzyme and pathway databases

ReactomeiREACT_283017. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, slow skeletal muscle
Short name:
TnTs
Alternative name(s):
Slow skeletal muscle troponin T
Short name:
sTnT
Gene namesi
Name:Tnnt1
Synonyms:Fang2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621852. Tnnt1.

Subcellular locationi

GO - Cellular componenti

  1. troponin complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Troponin T, slow skeletal musclePRO_0000186171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Phosphoserine; by CK2By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ7TNB2.

Expressioni

Tissue specificityi

Expressed in soleus muscle. Isoform 4 is predominanatly expressed in fast muscles.1 Publication

Gene expression databases

ExpressionAtlasiQ7TNB2. baseline and differential.
GenevestigatoriQ7TNB2.

Structurei

3D structure databases

ProteinModelPortaliQ7TNB2.
SMRiQ7TNB2. Positions 65-98, 173-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiNOG299534.
GeneTreeiENSGT00390000013611.
HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiQ7TNB2.
KOiK10372.
OMAiGRNFVIQ.
OrthoDBiEOG7W155J.
PhylomeDBiQ7TNB2.

Family and domain databases

InterProiIPR027707. TNNT.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TNB2-1) [UniParc]FASTAAdd to basket

Also known as: sTnT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTEEQEYE EEQAEDEEAV EEEAPEEPEP VAEREEERPK PSRPVVPPLI
60 70 80 90 100
PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD
110 120 130 140 150
RIERRRAERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK
160 170 180 190 200
KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KLRILSERKK PLNIDYMGED
210 220 230 240 250
QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR ISHAQKFRKG
260
AGKGRVGGRW K

Note: Major.

Length:261
Mass (Da):31,215
Last modified:January 23, 2007 - v3
Checksum:iB323364DBCAB5863
GO
Isoform 2 (identifier: Q7TNB2-2) [UniParc]FASTAAdd to basket

Also known as: sTnT2

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: Missing.

Note: Major.

Show »
Length:260
Mass (Da):31,086
Checksum:i3ECE14856D3FAE4D
GO
Isoform 3 (identifier: Q7TNB2-3) [UniParc]FASTAAdd to basket

Also known as: sTnT3

The sequence of this isoform differs from the canonical sequence as follows:
     24-34: Missing.
     35-35: Missing.

Note: Minor.

Show »
Length:249
Mass (Da):29,881
Checksum:i6CEFF688EF129079
GO
Isoform 4 (identifier: Q7TNB2-4) [UniParc]FASTAAdd to basket

Also known as: sTnTx

The sequence of this isoform differs from the canonical sequence as follows:
     24-34: Missing.

Note: Minor.

Show »
Length:250
Mass (Da):30,010
Checksum:i98B117AFB129755D
GO

Sequence cautioni

The sequence AAK94010.1 differs from that shown. Reason: Erroneous termination at position 229. Translated as Gln.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 3411Missing in isoform 3 and isoform 4. 1 PublicationVSP_013789Add
BLAST
Alternative sequencei35 – 351Missing in isoform 2 and isoform 3. 1 PublicationVSP_013790

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY334079 mRNA. Translation: AAQ19259.1.
AY334080 mRNA. Translation: AAQ19260.1.
AY334081 mRNA. Translation: AAQ19261.1.
AY334082 mRNA. Translation: AAQ19262.1.
AF399874 mRNA. Translation: AAK94010.1. Sequence problems.
RefSeqiNP_001264189.1. NM_001277260.1. [Q7TNB2-2]
NP_001264190.1. NM_001277261.2. [Q7TNB2-3]
NP_001264191.1. NM_001277262.2. [Q7TNB2-4]
NP_599215.2. NM_134388.2. [Q7TNB2-1]
UniGeneiRn.13846.

Genome annotation databases

EnsembliENSRNOT00000034957; ENSRNOP00000038327; ENSRNOG00000028041. [Q7TNB2-1]
GeneIDi171409.
KEGGirno:171409.
UCSCiRGD:621852. rat. [Q7TNB2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY334079 mRNA. Translation: AAQ19259.1.
AY334080 mRNA. Translation: AAQ19260.1.
AY334081 mRNA. Translation: AAQ19261.1.
AY334082 mRNA. Translation: AAQ19262.1.
AF399874 mRNA. Translation: AAK94010.1. Sequence problems.
RefSeqiNP_001264189.1. NM_001277260.1. [Q7TNB2-2]
NP_001264190.1. NM_001277261.2. [Q7TNB2-3]
NP_001264191.1. NM_001277262.2. [Q7TNB2-4]
NP_599215.2. NM_134388.2. [Q7TNB2-1]
UniGeneiRn.13846.

3D structure databases

ProteinModelPortaliQ7TNB2.
SMRiQ7TNB2. Positions 65-98, 173-246.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7TNB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034957; ENSRNOP00000038327; ENSRNOG00000028041. [Q7TNB2-1]
GeneIDi171409.
KEGGirno:171409.
UCSCiRGD:621852. rat. [Q7TNB2-1]

Organism-specific databases

CTDi7138.
RGDi621852. Tnnt1.

Phylogenomic databases

eggNOGiNOG299534.
GeneTreeiENSGT00390000013611.
HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiQ7TNB2.
KOiK10372.
OMAiGRNFVIQ.
OrthoDBiEOG7W155J.
PhylomeDBiQ7TNB2.

Enzyme and pathway databases

ReactomeiREACT_283017. Striated Muscle Contraction.

Miscellaneous databases

NextBioi622284.
PROiQ7TNB2.

Gene expression databases

ExpressionAtlasiQ7TNB2. baseline and differential.
GenevestigatoriQ7TNB2.

Family and domain databases

InterProiIPR027707. TNNT.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles."
    Kischel P., Bastide B., Muller M., Dubail F., Offredi F., Jin J.-P., Mounier Y., Martial J.
    Am. J. Physiol. 289:C437-C443(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
    Strain: Wistar.
  2. Chang Y.Y., Zuo J.J., Fang F.F.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiTNNT1_RAT
AccessioniPrimary (citable) accession number: Q7TNB2
Secondary accession number(s): Q7TNA9
, Q7TNB0, Q7TNB1, Q923S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.