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Q7TNB2 (TNNT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Troponin T, slow skeletal muscle
Short name=TnTs
Alternative name(s):
Slow skeletal muscle troponin T
Short name=sTnT
Gene names
Name:Tnnt1
Synonyms:Fang2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Tissue specificity

Expressed in soleus muscle. Isoform 4 is predominanatly expressed in fast muscles. Ref.1

Sequence similarities

Belongs to the troponin T family.

Sequence caution

The sequence AAK94010.1 differs from that shown. Reason: Erroneous termination at position 229. Translated as Gln.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionMuscle protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of muscle contraction

Inferred from direct assay PubMed 16192301. Source: RGD

slow-twitch skeletal muscle fiber contraction

Inferred from direct assay Ref.1. Source: RGD

   Cellular_componenttroponin complex

Inferred from direct assay Ref.1PubMed 16192301. Source: RGD

   Molecular_functiontroponin T binding

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7TNB2-1)

Also known as: sTnT1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Major.
Isoform 2 (identifier: Q7TNB2-2)

Also known as: sTnT2;

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: Missing.
Note: Major.
Isoform 3 (identifier: Q7TNB2-3)

Also known as: sTnT3;

The sequence of this isoform differs from the canonical sequence as follows:
     24-34: Missing.
     35-35: Missing.
Note: Minor.
Isoform 4 (identifier: Q7TNB2-4)

Also known as: sTnTx;

The sequence of this isoform differs from the canonical sequence as follows:
     24-34: Missing.
Note: Minor.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Troponin T, slow skeletal muscle
PRO_0000186171

Amino acid modifications

Modified residue21Phosphoserine; by CK2 By similarity

Natural variations

Alternative sequence24 – 3411Missing in isoform 3 and isoform 4.
VSP_013789
Alternative sequence351Missing in isoform 2 and isoform 3.
VSP_013790

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (sTnT1) [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B323364DBCAB5863

FASTA26131,215
        10         20         30         40         50         60 
MSDTEEQEYE EEQAEDEEAV EEEAPEEPEP VAEREEERPK PSRPVVPPLI PPKIPEGERV 

        70         80         90        100        110        120 
DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD RIERRRAERA EQQRFRTEKE 

       130        140        150        160        170        180 
RERQAKLAEE KMRKEEEEAK KRAEDDAKKK KVLSNMGAHF GGYLVKAEQK RGKRQTGREM 

       190        200        210        220        230        240 
KLRILSERKK PLNIDYMGED QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR 

       250        260 
ISHAQKFRKG AGKGRVGGRW K

« Hide

Isoform 2 (sTnT2) [UniParc].

Checksum: 3ECE14856D3FAE4D
Show »

FASTA26031,086
Isoform 3 (sTnT3) [UniParc].

Checksum: 6CEFF688EF129079
Show »

FASTA24929,881
Isoform 4 (sTnTx) [UniParc].

Checksum: 98B117AFB129755D
Show »

FASTA25030,010

References

[1]"Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles."
Kischel P., Bastide B., Muller M., Dubail F., Offredi F., Jin J.-P., Mounier Y., Martial J.
Am. J. Physiol. 289:C437-C443(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
Strain: Wistar.
[2]Chang Y.Y., Zuo J.J., Fang F.F.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY334079 mRNA. Translation: AAQ19259.1.
AY334080 mRNA. Translation: AAQ19260.1.
AY334081 mRNA. Translation: AAQ19261.1.
AY334082 mRNA. Translation: AAQ19262.1.
AF399874 mRNA. Translation: AAK94010.1. Sequence problems.
IPIIPI00382154.
IPI00563170.
IPI00607116.
IPI00607128.
RefSeqNP_599215.1. NM_134388.1.
UniGeneRn.13846.

3D structure databases

ProteinModelPortalQ7TNB2.
SMRQ7TNB2. Positions 65-98, 173-246.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000034957; ENSRNOP00000038327; ENSRNOG00000028041.
GeneID171409.
KEGGrno:171409.
UCSCRGD:621852. rat.

Organism-specific databases

CTD7138.
RGD621852. Tnnt1.

Phylogenomic databases

eggNOGNOG299534.
GeneTreeENSGT00390000013611.
HOGENOMHOG000231049.
HOVERGENHBG052790.
InParanoidQ7TNB2.
KOK10372.
OMAKERDRQT.
OrthoDBEOG4MCX1P.

Gene expression databases

GenevestigatorQ7TNB2.
GermOnlineENSRNOG00000028041. Rattus norvegicus.

Family and domain databases

InterProIPR001978. Troponin.
[Graphical view]
PfamPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622284.

Entry information

Entry nameTNNT1_RAT
AccessionPrimary (citable) accession number: Q7TNB2
Secondary accession number(s): Q7TNA9 expand/collapse secondary AC list , Q7TNB0, Q7TNB1, Q923S7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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