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Protein

Troponin T, slow skeletal muscle

Gene

Tnnt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • tropomyosin binding Source: Ensembl
  • troponin T binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-RNO-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, slow skeletal muscle
Short name:
TnTs
Alternative name(s):
Slow skeletal muscle troponin T
Short name:
sTnT
Gene namesi
Name:Tnnt1
Synonyms:Fang2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621852 Tnnt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861711 – 261Troponin T, slow skeletal muscleAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TNB2
PRIDEiQ7TNB2

PTM databases

iPTMnetiQ7TNB2
PhosphoSitePlusiQ7TNB2

Expressioni

Tissue specificityi

Expressed in soleus muscle. Isoform 4 is predominantly expressed in fast muscles.1 Publication

Gene expression databases

BgeeiENSRNOG00000028041
GenevisibleiQ7TNB2 RN

Interactioni

GO - Molecular functioni

  • tropomyosin binding Source: Ensembl
  • troponin T binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038327

Structurei

3D structure databases

ProteinModelPortaliQ7TNB2
SMRiQ7TNB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiQ7TNB2
KOiK10372
OMAiDHMGEEQ
OrthoDBiEOG091G0U67
PhylomeDBiQ7TNB2

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TNB2-1) [UniParc]FASTAAdd to basket
Also known as: sTnT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTEEQEYE EEQAEDEEAV EEEAPEEPEP VAEREEERPK PSRPVVPPLI
60 70 80 90 100
PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD
110 120 130 140 150
RIERRRAERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK
160 170 180 190 200
KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KLRILSERKK PLNIDYMGED
210 220 230 240 250
QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR ISHAQKFRKG
260
AGKGRVGGRW K
Note: Major.
Length:261
Mass (Da):31,215
Last modified:January 23, 2007 - v3
Checksum:iB323364DBCAB5863
GO
Isoform 2 (identifier: Q7TNB2-2) [UniParc]FASTAAdd to basket
Also known as: sTnT2

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: Missing.

Note: Major.
Show »
Length:260
Mass (Da):31,086
Checksum:i3ECE14856D3FAE4D
GO
Isoform 3 (identifier: Q7TNB2-3) [UniParc]FASTAAdd to basket
Also known as: sTnT3

The sequence of this isoform differs from the canonical sequence as follows:
     24-34: Missing.
     35-35: Missing.

Note: Minor.
Show »
Length:249
Mass (Da):29,881
Checksum:i6CEFF688EF129079
GO
Isoform 4 (identifier: Q7TNB2-4) [UniParc]FASTAAdd to basket
Also known as: sTnTx

The sequence of this isoform differs from the canonical sequence as follows:
     24-34: Missing.

Note: Minor.
Show »
Length:250
Mass (Da):30,010
Checksum:i98B117AFB129755D
GO

Sequence cautioni

The sequence AAK94010 differs from that shown. Reason: Erroneous termination at position 229. Translated as Gln.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01378924 – 34Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_01379035Missing in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY334079 mRNA Translation: AAQ19259.1
AY334080 mRNA Translation: AAQ19260.1
AY334081 mRNA Translation: AAQ19261.1
AY334082 mRNA Translation: AAQ19262.1
AF399874 mRNA Translation: AAK94010.1 Sequence problems.
RefSeqiNP_001264189.1, NM_001277260.1 [Q7TNB2-2]
NP_001264190.1, NM_001277261.2 [Q7TNB2-3]
NP_001264191.1, NM_001277262.2 [Q7TNB2-4]
NP_599215.2, NM_134388.2 [Q7TNB2-1]
UniGeneiRn.13846

Genome annotation databases

EnsembliENSRNOT00000034957; ENSRNOP00000038327; ENSRNOG00000028041 [Q7TNB2-1]
ENSRNOT00000058843; ENSRNOP00000055633; ENSRNOG00000028041 [Q7TNB2-4]
GeneIDi171409
KEGGirno:171409
UCSCiRGD:621852 rat [Q7TNB2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT1_RAT
AccessioniPrimary (citable) accession number: Q7TNB2
Secondary accession number(s): Q7TNA9
, Q7TNB0, Q7TNB1, Q923S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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