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Q7TNB2

- TNNT1_RAT

UniProt

Q7TNB2 - TNNT1_RAT

Protein

Troponin T, slow skeletal muscle

Gene

Tnnt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    GO - Molecular functioni

    1. troponin T binding Source: RGD

    GO - Biological processi

    1. negative regulation of muscle contraction Source: Ensembl
    2. regulation of muscle contraction Source: RGD
    3. slow-twitch skeletal muscle fiber contraction Source: RGD

    Keywords - Molecular functioni

    Muscle protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin T, slow skeletal muscle
    Short name:
    TnTs
    Alternative name(s):
    Slow skeletal muscle troponin T
    Short name:
    sTnT
    Gene namesi
    Name:Tnnt1
    Synonyms:Fang2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621852. Tnnt1.

    Subcellular locationi

    GO - Cellular componenti

    1. troponin complex Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Troponin T, slow skeletal musclePRO_0000186171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Phosphoserine; by CK2By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ7TNB2.

    Expressioni

    Tissue specificityi

    Expressed in soleus muscle. Isoform 4 is predominanatly expressed in fast muscles.1 Publication

    Gene expression databases

    GenevestigatoriQ7TNB2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TNB2.
    SMRiQ7TNB2. Positions 65-98, 173-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the troponin T family.Curated

    Phylogenomic databases

    eggNOGiNOG299534.
    GeneTreeiENSGT00390000013611.
    HOGENOMiHOG000231049.
    HOVERGENiHBG052790.
    InParanoidiQ7TNB2.
    KOiK10372.
    OMAiMDYEIQQ.
    OrthoDBiEOG7W155J.
    PhylomeDBiQ7TNB2.

    Family and domain databases

    InterProiIPR027707. TNNT.
    IPR001978. Troponin.
    [Graphical view]
    PANTHERiPTHR11521. PTHR11521. 1 hit.
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TNB2-1) [UniParc]FASTAAdd to Basket

    Also known as: sTnT1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDTEEQEYE EEQAEDEEAV EEEAPEEPEP VAEREEERPK PSRPVVPPLI    50
    PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD 100
    RIERRRAERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK 150
    KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KLRILSERKK PLNIDYMGED 200
    QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR ISHAQKFRKG 250
    AGKGRVGGRW K 261

    Note: Major.

    Length:261
    Mass (Da):31,215
    Last modified:January 23, 2007 - v3
    Checksum:iB323364DBCAB5863
    GO
    Isoform 2 (identifier: Q7TNB2-2) [UniParc]FASTAAdd to Basket

    Also known as: sTnT2

    The sequence of this isoform differs from the canonical sequence as follows:
         35-35: Missing.

    Note: Major.

    Show »
    Length:260
    Mass (Da):31,086
    Checksum:i3ECE14856D3FAE4D
    GO
    Isoform 3 (identifier: Q7TNB2-3) [UniParc]FASTAAdd to Basket

    Also known as: sTnT3

    The sequence of this isoform differs from the canonical sequence as follows:
         24-34: Missing.
         35-35: Missing.

    Note: Minor.

    Show »
    Length:249
    Mass (Da):29,881
    Checksum:i6CEFF688EF129079
    GO
    Isoform 4 (identifier: Q7TNB2-4) [UniParc]FASTAAdd to Basket

    Also known as: sTnTx

    The sequence of this isoform differs from the canonical sequence as follows:
         24-34: Missing.

    Note: Minor.

    Show »
    Length:250
    Mass (Da):30,010
    Checksum:i98B117AFB129755D
    GO

    Sequence cautioni

    The sequence AAK94010.1 differs from that shown. Reason: Erroneous termination at position 229. Translated as Gln.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei24 – 3411Missing in isoform 3 and isoform 4. 1 PublicationVSP_013789Add
    BLAST
    Alternative sequencei35 – 351Missing in isoform 2 and isoform 3. 1 PublicationVSP_013790

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY334079 mRNA. Translation: AAQ19259.1.
    AY334080 mRNA. Translation: AAQ19260.1.
    AY334081 mRNA. Translation: AAQ19261.1.
    AY334082 mRNA. Translation: AAQ19262.1.
    AF399874 mRNA. Translation: AAK94010.1. Sequence problems.
    RefSeqiNP_001264189.1. NM_001277260.1. [Q7TNB2-2]
    NP_001264190.1. NM_001277261.2. [Q7TNB2-3]
    NP_001264191.1. NM_001277262.2. [Q7TNB2-4]
    NP_599215.2. NM_134388.2. [Q7TNB2-1]
    XP_006228309.1. XM_006228247.1. [Q7TNB2-1]
    UniGeneiRn.13846.

    Genome annotation databases

    EnsembliENSRNOT00000034957; ENSRNOP00000038327; ENSRNOG00000028041. [Q7TNB2-1]
    GeneIDi171409.
    KEGGirno:171409.
    UCSCiRGD:621852. rat. [Q7TNB2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY334079 mRNA. Translation: AAQ19259.1 .
    AY334080 mRNA. Translation: AAQ19260.1 .
    AY334081 mRNA. Translation: AAQ19261.1 .
    AY334082 mRNA. Translation: AAQ19262.1 .
    AF399874 mRNA. Translation: AAK94010.1 . Sequence problems.
    RefSeqi NP_001264189.1. NM_001277260.1. [Q7TNB2-2 ]
    NP_001264190.1. NM_001277261.2. [Q7TNB2-3 ]
    NP_001264191.1. NM_001277262.2. [Q7TNB2-4 ]
    NP_599215.2. NM_134388.2. [Q7TNB2-1 ]
    XP_006228309.1. XM_006228247.1. [Q7TNB2-1 ]
    UniGenei Rn.13846.

    3D structure databases

    ProteinModelPortali Q7TNB2.
    SMRi Q7TNB2. Positions 65-98, 173-246.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7TNB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000034957 ; ENSRNOP00000038327 ; ENSRNOG00000028041 . [Q7TNB2-1 ]
    GeneIDi 171409.
    KEGGi rno:171409.
    UCSCi RGD:621852. rat. [Q7TNB2-1 ]

    Organism-specific databases

    CTDi 7138.
    RGDi 621852. Tnnt1.

    Phylogenomic databases

    eggNOGi NOG299534.
    GeneTreei ENSGT00390000013611.
    HOGENOMi HOG000231049.
    HOVERGENi HBG052790.
    InParanoidi Q7TNB2.
    KOi K10372.
    OMAi MDYEIQQ.
    OrthoDBi EOG7W155J.
    PhylomeDBi Q7TNB2.

    Miscellaneous databases

    NextBioi 622284.
    PROi Q7TNB2.

    Gene expression databases

    Genevestigatori Q7TNB2.

    Family and domain databases

    InterProi IPR027707. TNNT.
    IPR001978. Troponin.
    [Graphical view ]
    PANTHERi PTHR11521. PTHR11521. 1 hit.
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles."
      Kischel P., Bastide B., Muller M., Dubail F., Offredi F., Jin J.-P., Mounier Y., Martial J.
      Am. J. Physiol. 289:C437-C443(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
      Strain: Wistar.
    2. Chang Y.Y., Zuo J.J., Fang F.F.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiTNNT1_RAT
    AccessioniPrimary (citable) accession number: Q7TNB2
    Secondary accession number(s): Q7TNA9
    , Q7TNB0, Q7TNB1, Q923S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3