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Protein

L-lactate dehydrogenase

Gene

Ldhal6b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase C chain (Ldhc), L-lactate dehydrogenase, L-lactate dehydrogenase (Ldhc)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei156SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Active sitei243Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Ldhal6bImported
Synonyms:LdhlImported
ORF Names:rCG_63067Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi727955 Ldhal6b

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ7TNA8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 210Ldh_1_NInterPro annotationAdd BLAST139
Domaini214 – 379Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000462
KOiK00016

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TNA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWAVSILRA RRRMGTVRVD FKDLGVALWP SQVLRVPPNR AWWSLTPTST
60 70 80 90 100
MATVKGKLLQ HVSSEEPVLH NKVSIIGTGS VGMACAISII AKGLTDELAL
110 120 130 140 150
VDSNEGKMKG ETMDLQHGSV FMKMPNIVCS KDFHVTANSE VVVITAGARQ
160 170 180 190 200
EKDETRLNLV QRNVSIFKIM FANIVKYSPR CKIIIVSNPV DILTYVAWKL
210 220 230 240 250
SGFPKNRVIG SGCNLDTARF RYMLGQRLGI HSESCHGWVL GEHGDSSVPV
260 270 280 290 300
WSGVNIAGVP LKELNSAIGT NKDPEQWGNV HKEVIASAYK IIKMKGYTSW
310 320 330 340 350
AIGLSVADIA ESILKNLRKT HPVSTKIKGL YGIKEEVFLS VPCVLGENGI
360 370 380
SDIIKVKLSP TEEAQMVKSA DTIWKIQKDI KF
Length:382
Mass (Da):42,049
Last modified:October 1, 2003 - v1
Checksum:iE09828A1F78B716F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078970 mRNA Translation: AAH78970.1
AY342428 mRNA Translation: AAQ20046.1
CH474077 Genomic DNA Translation: EDL83739.1
RefSeqiNP_899163.1, NM_183334.1
UniGeneiRn.208286

Genome annotation databases

GeneIDi369018
KEGGirno:369018

Similar proteinsi

Entry informationi

Entry nameiQ7TNA8_RAT
AccessioniPrimary (citable) accession number: Q7TNA8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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