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Protein

L-lactate dehydrogenase

Gene

Ldhal6b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase C chain (Ldhc), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei243 – 2431Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Ldhal6bImported
Synonyms:LdhlImported
ORF Names:rCG_63067Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi727955. Ldhal6b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ7TNA8.

Structurei

3D structure databases

SMRiQ7TNA8. Positions 52-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 210139Ldh_1_NInterPro annotationAdd
BLAST
Domaini214 – 379166Ldh_1_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000462.
KOiK00016.
PhylomeDBiQ7TNA8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TNA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWAVSILRA RRRMGTVRVD FKDLGVALWP SQVLRVPPNR AWWSLTPTST
60 70 80 90 100
MATVKGKLLQ HVSSEEPVLH NKVSIIGTGS VGMACAISII AKGLTDELAL
110 120 130 140 150
VDSNEGKMKG ETMDLQHGSV FMKMPNIVCS KDFHVTANSE VVVITAGARQ
160 170 180 190 200
EKDETRLNLV QRNVSIFKIM FANIVKYSPR CKIIIVSNPV DILTYVAWKL
210 220 230 240 250
SGFPKNRVIG SGCNLDTARF RYMLGQRLGI HSESCHGWVL GEHGDSSVPV
260 270 280 290 300
WSGVNIAGVP LKELNSAIGT NKDPEQWGNV HKEVIASAYK IIKMKGYTSW
310 320 330 340 350
AIGLSVADIA ESILKNLRKT HPVSTKIKGL YGIKEEVFLS VPCVLGENGI
360 370 380
SDIIKVKLSP TEEAQMVKSA DTIWKIQKDI KF
Length:382
Mass (Da):42,049
Last modified:October 1, 2003 - v1
Checksum:iE09828A1F78B716F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078970 mRNA. Translation: AAH78970.1.
AY342428 mRNA. Translation: AAQ20046.1.
CH474077 Genomic DNA. Translation: EDL83739.1.
RefSeqiNP_899163.1. NM_183334.1.
UniGeneiRn.208286.

Genome annotation databases

GeneIDi369018.
KEGGirno:369018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078970 mRNA. Translation: AAH78970.1.
AY342428 mRNA. Translation: AAQ20046.1.
CH474077 Genomic DNA. Translation: EDL83739.1.
RefSeqiNP_899163.1. NM_183334.1.
UniGeneiRn.208286.

3D structure databases

SMRiQ7TNA8. Positions 52-382.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ7TNA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi369018.
KEGGirno:369018.

Organism-specific databases

CTDi92483.
RGDi727955. Ldhal6b.

Phylogenomic databases

HOVERGENiHBG000462.
KOiK00016.
PhylomeDBiQ7TNA8.

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TNA8_RAT
AccessioniPrimary (citable) accession number: Q7TNA8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.