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Protein

L-lactate dehydrogenase

Gene

Ldhal6b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase C chain (Ldhc), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei156SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Active sitei243Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Ldhal6bImported
Synonyms:LdhlImported
ORF Names:rCG_63067Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi727955. Ldhal6b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 210Ldh_1_NInterPro annotationAdd BLAST139
Domaini214 – 379Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000462.
KOiK00016.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TNA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWAVSILRA RRRMGTVRVD FKDLGVALWP SQVLRVPPNR AWWSLTPTST
60 70 80 90 100
MATVKGKLLQ HVSSEEPVLH NKVSIIGTGS VGMACAISII AKGLTDELAL
110 120 130 140 150
VDSNEGKMKG ETMDLQHGSV FMKMPNIVCS KDFHVTANSE VVVITAGARQ
160 170 180 190 200
EKDETRLNLV QRNVSIFKIM FANIVKYSPR CKIIIVSNPV DILTYVAWKL
210 220 230 240 250
SGFPKNRVIG SGCNLDTARF RYMLGQRLGI HSESCHGWVL GEHGDSSVPV
260 270 280 290 300
WSGVNIAGVP LKELNSAIGT NKDPEQWGNV HKEVIASAYK IIKMKGYTSW
310 320 330 340 350
AIGLSVADIA ESILKNLRKT HPVSTKIKGL YGIKEEVFLS VPCVLGENGI
360 370 380
SDIIKVKLSP TEEAQMVKSA DTIWKIQKDI KF
Length:382
Mass (Da):42,049
Last modified:October 1, 2003 - v1
Checksum:iE09828A1F78B716F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078970 mRNA. Translation: AAH78970.1.
AY342428 mRNA. Translation: AAQ20046.1.
CH474077 Genomic DNA. Translation: EDL83739.1.
RefSeqiNP_899163.1. NM_183334.1.
UniGeneiRn.208286.

Genome annotation databases

GeneIDi369018.
KEGGirno:369018.

Similar proteinsi

Entry informationi

Entry nameiQ7TNA8_RAT
AccessioniPrimary (citable) accession number: Q7TNA8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)