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Protein

GTPase ERas

Gene

Eras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.1 Publication

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 55GTPBy similarity8
Nucleotide bindingi95 – 99GTPBy similarity5
Nucleotide bindingi151 – 154GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ERas
Short name:
E-Ras
Alternative name(s):
Embryonic stem cell-expressed Ras
Gene namesi
Name:Eras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2665023 Eras

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475401 – 224GTPase ERasAdd BLAST224
PropeptideiPRO_0000247541225 – 227Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi220S-palmitoyl cysteineBy similarity1
Lipidationi222S-palmitoyl cysteineBy similarity1
Modified residuei224Cysteine methyl esterBy similarity1
Lipidationi224S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ7TN89
PRIDEiQ7TN89

PTM databases

iPTMnetiQ7TN89
PhosphoSitePlusiQ7TN89

Expressioni

Tissue specificityi

Expressed in several undifferentiated mouse embryonic stem cell lines.1 Publication

Gene expression databases

BgeeiENSMUSG00000031160
CleanExiMM_ERAS
ExpressionAtlasiQ7TN89 baseline and differential
GenevisibleiQ7TN89 MM

Interactioni

Subunit structurei

Interacts with PIK3CD.1 Publication

Protein-protein interaction databases

IntActiQ7TN89, 1 interactor
STRINGi10090.ENSMUSP00000033500

Structurei

3D structure databases

ProteinModelPortaliQ7TN89
SMRiQ7TN89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi70 – 78Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ7TN89
KOiK17196
OMAiRATWGPH
OrthoDBiEOG091G0L0E
PhylomeDBiQ7TN89
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TN89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPTKSSIL DLSSGTPCTR SPEESHEAWA QCKDAGRQLP EYKAVVVGAS
60 70 80 90 100
GVGKSALTIQ MTHQCFVKDH DPTIQDSYWK EVARDNGGYI LNVLDTSGQD
110 120 130 140 150
IHRALRDQCL ASGDGVLGVF ALDDPSSLDQ LQQIWSTWTP HHKQPLVLVG
160 170 180 190 200
NKCDLVTTAG DAHAAAALLA HKLGAPLVKT SAKTRQGVEE AFALLVHEIQ
210 220
RAQEAVAESS KKTRHQKAVC SCGCSVA
Length:227
Mass (Da):24,321
Last modified:October 1, 2003 - v1
Checksum:i0F0EC10163027FCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093573 mRNA Translation: BAC76996.1
AK141212 mRNA Translation: BAE24591.1
CCDSiCCDS29980.1
RefSeqiNP_853526.1, NM_181548.2
UniGeneiMm.250895

Genome annotation databases

EnsembliENSMUST00000033500; ENSMUSP00000033500; ENSMUSG00000031160
GeneIDi353283
KEGGimmu:353283
UCSCiuc009sng.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRASE_MOUSE
AccessioniPrimary (citable) accession number: Q7TN89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health