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Protein

GTPase ERas

Gene

Eras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.1 Publication

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 558GTPBy similarity
Nucleotide bindingi95 – 995GTPBy similarity
Nucleotide bindingi151 – 1544GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ERas
Short name:
E-Ras
Alternative name(s):
Embryonic stem cell-expressed Ras
Gene namesi
Name:Eras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2665023. Eras.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224GTPase ERasPRO_0000247540Add
BLAST
Propeptidei225 – 2273Removed in mature formBy similarityPRO_0000247541

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi220 – 2201S-palmitoyl cysteineBy similarity
Lipidationi222 – 2221S-palmitoyl cysteineBy similarity
Modified residuei224 – 2241Cysteine methyl esterBy similarity
Lipidationi224 – 2241S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiQ7TN89.
PaxDbiQ7TN89.
PRIDEiQ7TN89.

PTM databases

iPTMnetiQ7TN89.
PhosphoSiteiQ7TN89.

Expressioni

Tissue specificityi

Expressed in several undifferentiated mouse embryonic stem cell lines.1 Publication

Gene expression databases

BgeeiQ7TN89.
CleanExiMM_ERAS.
ExpressionAtlasiQ7TN89. baseline and differential.
GenevisibleiQ7TN89. MM.

Interactioni

Subunit structurei

Interacts with PIK3CD.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033500.

Structurei

3D structure databases

ProteinModelPortaliQ7TN89.
SMRiQ7TN89. Positions 39-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 789Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ7TN89.
KOiK17196.
OMAiRATWGPH.
OrthoDBiEOG7BS4BJ.
PhylomeDBiQ7TN89.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TN89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPTKSSIL DLSSGTPCTR SPEESHEAWA QCKDAGRQLP EYKAVVVGAS
60 70 80 90 100
GVGKSALTIQ MTHQCFVKDH DPTIQDSYWK EVARDNGGYI LNVLDTSGQD
110 120 130 140 150
IHRALRDQCL ASGDGVLGVF ALDDPSSLDQ LQQIWSTWTP HHKQPLVLVG
160 170 180 190 200
NKCDLVTTAG DAHAAAALLA HKLGAPLVKT SAKTRQGVEE AFALLVHEIQ
210 220
RAQEAVAESS KKTRHQKAVC SCGCSVA
Length:227
Mass (Da):24,321
Last modified:October 1, 2003 - v1
Checksum:i0F0EC10163027FCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093573 mRNA. Translation: BAC76996.1.
AK141212 mRNA. Translation: BAE24591.1.
CCDSiCCDS29980.1.
RefSeqiNP_853526.1. NM_181548.2.
UniGeneiMm.250895.

Genome annotation databases

EnsembliENSMUST00000033500; ENSMUSP00000033500; ENSMUSG00000031160.
GeneIDi353283.
KEGGimmu:353283.
UCSCiuc009sng.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093573 mRNA. Translation: BAC76996.1.
AK141212 mRNA. Translation: BAE24591.1.
CCDSiCCDS29980.1.
RefSeqiNP_853526.1. NM_181548.2.
UniGeneiMm.250895.

3D structure databases

ProteinModelPortaliQ7TN89.
SMRiQ7TN89. Positions 39-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033500.

PTM databases

iPTMnetiQ7TN89.
PhosphoSiteiQ7TN89.

Proteomic databases

MaxQBiQ7TN89.
PaxDbiQ7TN89.
PRIDEiQ7TN89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033500; ENSMUSP00000033500; ENSMUSG00000031160.
GeneIDi353283.
KEGGimmu:353283.
UCSCiuc009sng.1. mouse.

Organism-specific databases

CTDi3266.
MGIiMGI:2665023. Eras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ7TN89.
KOiK17196.
OMAiRATWGPH.
OrthoDBiEOG7BS4BJ.
PhylomeDBiQ7TN89.
TreeFamiTF312796.

Miscellaneous databases

PROiQ7TN89.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TN89.
CleanExiMM_ERAS.
ExpressionAtlasiQ7TN89. baseline and differential.
GenevisibleiQ7TN89. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Role of Eras in promoting tumor-like properties in mouse embryonic stem cells."
    Takahashi K., Mitsui K., Yamanaka S.
    Nature 423:541-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH PIK3CD.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiRASE_MOUSE
AccessioniPrimary (citable) accession number: Q7TN89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.