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Protein

Synaptotagmin-14

Gene

Syt14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • clathrin binding Source: GO_Central
  • phospholipid binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • syntaxin binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-14
Alternative name(s):
Synaptotagmin XIV
Short name:
SytXIV
Gene namesi
Name:Syt14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444490. Syt14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4723Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
BLAST
Topological domaini48 – 555508CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Synaptotagmin-14PRO_0000183979Add
BLAST

Proteomic databases

PRIDEiQ7TN84.

PTM databases

PhosphoSiteiQ7TN84.

Expressioni

Tissue specificityi

Expressed in heart and testis. Expressed in brain (especially in the cerebellum).2 Publications

Gene expression databases

BgeeiQ7TN84.
CleanExiMM_SYT14.
ExpressionAtlasiQ7TN84. baseline and differential.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4997547.
STRINGi10090.ENSMUSP00000016344.

Structurei

3D structure databases

ProteinModelPortaliQ7TN84.
SMRiQ7TN84. Positions 259-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 378103C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini417 – 521105C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305739.
GeneTreeiENSGT00560000077240.
HOVERGENiHBG062897.
InParanoidiQ7TN84.
OMAiGDSKCEF.
OrthoDBiEOG7DRJ31.
PhylomeDBiQ7TN84.
TreeFamiTF351132.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028696. SYT14.
[Graphical view]
PANTHERiPTHR10024:SF209. PTHR10024:SF209. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIVLML LLFLYINKKF
60 70 80 90 100
CFENVGGFPD LGSGYNTRTN SQDKMYNSYM DRDEPGSSSE SEDEALGKYH
110 120 130 140 150
EALSRTHNSR WPLVDSRQKS YAWETRQKYS PLSAEYDGYS TEASMEDGNC
160 170 180 190 200
IQRMRRTPPL DELQPPPYQD DSGSPHLSCT PSEIGDAKCE ISHCSNSPRC
210 220 230 240 250
SFNKCPSEGS TGHEAESYHN KGYEDDVPSD STAVLSPEDM SAQGSSSQLP
260 270 280 290 300
KPFDPEPEAK YGTLDVTFDY DSERQKLLVT VTAVTDIPTY NRTGGNSWQV
310 320 330 340 350
HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV
360 370 380 390 400
HRMKKEKIVG EKIFYLTKLN LQGKMSLPVI LEPSYNPSGC DSQVSLSEAS
410 420 430 440 450
CGDSTSSCQS LQHGSVPEIL IGLLYNATTG RLSAEVIKGS HFKNLAANRP
460 470 480 490 500
PNTYVKLTLL NSMGQEMSKC KTSTRRGQPN PVYKETFVFQ VALFQLSDVT
510 520 530 540 550
LILSVYNRRS MKRKEMIGWI SLGLNSSGEE ELRHWTAMKE SKGQQVCRWH

ALLES
Length:555
Mass (Da):62,044
Last modified:October 1, 2003 - v1
Checksum:i7728CA866BFBA84E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102947 mRNA. Translation: BAC76808.1.
CCDSiCCDS48489.1.
RefSeqiNP_853524.1. NM_181546.3.
UniGeneiMm.170401.
Mm.76710.

Genome annotation databases

EnsembliENSMUST00000195354; ENSMUSP00000142190; ENSMUSG00000016200.
GeneIDi329324.
KEGGimmu:329324.
UCSCiuc007edu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102947 mRNA. Translation: BAC76808.1.
CCDSiCCDS48489.1.
RefSeqiNP_853524.1. NM_181546.3.
UniGeneiMm.170401.
Mm.76710.

3D structure databases

ProteinModelPortaliQ7TN84.
SMRiQ7TN84. Positions 259-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997547.
STRINGi10090.ENSMUSP00000016344.

PTM databases

PhosphoSiteiQ7TN84.

Proteomic databases

PRIDEiQ7TN84.

Protocols and materials databases

DNASUi329324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000195354; ENSMUSP00000142190; ENSMUSG00000016200.
GeneIDi329324.
KEGGimmu:329324.
UCSCiuc007edu.1. mouse.

Organism-specific databases

CTDi255928.
MGIiMGI:2444490. Syt14.

Phylogenomic databases

eggNOGiNOG305739.
GeneTreeiENSGT00560000077240.
HOVERGENiHBG062897.
InParanoidiQ7TN84.
OMAiGDSKCEF.
OrthoDBiEOG7DRJ31.
PhylomeDBiQ7TN84.
TreeFamiTF351132.

Miscellaneous databases

NextBioi398680.
PROiQ7TN84.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TN84.
CleanExiMM_SYT14.
ExpressionAtlasiQ7TN84. baseline and differential.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028696. SYT14.
[Graphical view]
PANTHERiPTHR10024:SF209. PTHR10024:SF209. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans."
    Fukuda M.
    J. Biochem. 133:641-649(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
  2. "Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation."
    Doi H., Yoshida K., Yasuda T., Fukuda M., Fukuda Y., Morita H., Ikeda S., Kato R., Tsurusaki Y., Miyake N., Saitsu H., Sakai H., Miyatake S., Shiina M., Nukina N., Koyano S., Tsuji S., Kuroiwa Y., Matsumoto N.
    Am. J. Hum. Genet. 89:320-327(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSYT14_MOUSE
AccessioniPrimary (citable) accession number: Q7TN84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.