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Q7TN84 (SYT14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-14
Alternative name(s):
Synaptotagmin XIV
Short name=SytXIV
Gene names
Name:Syt14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

Subunit structure

Homodimer. Can also form heterodimers By similarity.

Subcellular location

Membrane; Single-pass type III membrane protein Potential.

Tissue specificity

Expressed in heart and testis. Expressed in brain (especially in the cerebellum). Ref.1 Ref.2

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Synaptotagmin-14
PRO_0000183979

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4723Helical; Signal-anchor for type III membrane protein; Potential
Topological domain48 – 555508Cytoplasmic Potential
Domain276 – 378103C2 1
Domain417 – 521105C2 2

Sequences

Sequence LengthMass (Da)Tools
Q7TN84 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7728CA866BFBA84E

FASTA55562,044
        10         20         30         40         50         60 
MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIVLML LLFLYINKKF CFENVGGFPD 

        70         80         90        100        110        120 
LGSGYNTRTN SQDKMYNSYM DRDEPGSSSE SEDEALGKYH EALSRTHNSR WPLVDSRQKS 

       130        140        150        160        170        180 
YAWETRQKYS PLSAEYDGYS TEASMEDGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT 

       190        200        210        220        230        240 
PSEIGDAKCE ISHCSNSPRC SFNKCPSEGS TGHEAESYHN KGYEDDVPSD STAVLSPEDM 

       250        260        270        280        290        300 
SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSERQKLLVT VTAVTDIPTY NRTGGNSWQV 

       310        320        330        340        350        360 
HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG 

       370        380        390        400        410        420 
EKIFYLTKLN LQGKMSLPVI LEPSYNPSGC DSQVSLSEAS CGDSTSSCQS LQHGSVPEIL 

       430        440        450        460        470        480 
IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNTYVKLTLL NSMGQEMSKC KTSTRRGQPN 

       490        500        510        520        530        540 
PVYKETFVFQ VALFQLSDVT LILSVYNRRS MKRKEMIGWI SLGLNSSGEE ELRHWTAMKE 

       550 
SKGQQVCRWH ALLES 

« Hide

References

[1]"Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans."
Fukuda M.
J. Biochem. 133:641-649(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
[2]"Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation."
Doi H., Yoshida K., Yasuda T., Fukuda M., Fukuda Y., Morita H., Ikeda S., Kato R., Tsurusaki Y., Miyake N., Saitsu H., Sakai H., Miyatake S., Shiina M., Nukina N., Koyano S., Tsuji S., Kuroiwa Y., Matsumoto N.
Am. J. Hum. Genet. 89:320-327(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB102947 mRNA. Translation: BAC76808.1.
RefSeqNP_853524.1. NM_181546.2.
UniGeneMm.170401.
Mm.76710.

3D structure databases

ProteinModelPortalQ7TN84.
SMRQ7TN84. Positions 259-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4997547.
STRING10090.ENSMUSP00000016344.

PTM databases

PhosphoSiteQ7TN84.

Proteomic databases

PRIDEQ7TN84.

Protocols and materials databases

DNASU329324.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016344; ENSMUSP00000016344; ENSMUSG00000016200.
GeneID329324.
KEGGmmu:329324.
UCSCuc007edu.1. mouse.

Organism-specific databases

CTD255928.
MGIMGI:2444490. Syt14.

Phylogenomic databases

eggNOGNOG305739.
GeneTreeENSGT00560000077240.
HOVERGENHBG062897.
InParanoidQ7TN84.
OMAGDSKCEF.
OrthoDBEOG7DRJ31.
PhylomeDBQ7TN84.
TreeFamTF351132.

Gene expression databases

BgeeQ7TN84.
CleanExMM_SYT14.
GenevestigatorQ7TN84.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR028696. SYT14.
[Graphical view]
PANTHERPTHR10024:SF14. PTHR10024:SF14. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio398680.
PROQ7TN84.
SOURCESearch...

Entry information

Entry nameSYT14_MOUSE
AccessionPrimary (citable) accession number: Q7TN84
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot