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Q7TN84

- SYT14_MOUSE

UniProt

Q7TN84 - SYT14_MOUSE

Protein

Synaptotagmin-14

Gene

Syt14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

    GO - Molecular functioni

    1. phospholipid binding Source: MGI
    2. protein heterodimerization activity Source: MGI
    3. protein homodimerization activity Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-14
    Alternative name(s):
    Synaptotagmin XIV
    Short name:
    SytXIV
    Gene namesi
    Name:Syt14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2444490. Syt14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Synaptotagmin-14PRO_0000183979Add
    BLAST

    Proteomic databases

    PRIDEiQ7TN84.

    PTM databases

    PhosphoSiteiQ7TN84.

    Expressioni

    Tissue specificityi

    Expressed in heart and testis. Expressed in brain (especially in the cerebellum).2 Publications

    Gene expression databases

    BgeeiQ7TN84.
    CleanExiMM_SYT14.
    GenevestigatoriQ7TN84.

    Interactioni

    Subunit structurei

    Homodimer. Can also form heterodimers By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-4997547.
    STRINGi10090.ENSMUSP00000016344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TN84.
    SMRiQ7TN84. Positions 259-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 555508CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4723Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini276 – 378103C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini417 – 521105C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305739.
    GeneTreeiENSGT00560000077240.
    HOVERGENiHBG062897.
    InParanoidiQ7TN84.
    OMAiGDSKCEF.
    OrthoDBiEOG7DRJ31.
    PhylomeDBiQ7TN84.
    TreeFamiTF351132.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR028696. SYT14.
    [Graphical view]
    PANTHERiPTHR10024:SF209. PTHR10024:SF209. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TN84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIVLML LLFLYINKKF    50
    CFENVGGFPD LGSGYNTRTN SQDKMYNSYM DRDEPGSSSE SEDEALGKYH 100
    EALSRTHNSR WPLVDSRQKS YAWETRQKYS PLSAEYDGYS TEASMEDGNC 150
    IQRMRRTPPL DELQPPPYQD DSGSPHLSCT PSEIGDAKCE ISHCSNSPRC 200
    SFNKCPSEGS TGHEAESYHN KGYEDDVPSD STAVLSPEDM SAQGSSSQLP 250
    KPFDPEPEAK YGTLDVTFDY DSERQKLLVT VTAVTDIPTY NRTGGNSWQV 300
    HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV 350
    HRMKKEKIVG EKIFYLTKLN LQGKMSLPVI LEPSYNPSGC DSQVSLSEAS 400
    CGDSTSSCQS LQHGSVPEIL IGLLYNATTG RLSAEVIKGS HFKNLAANRP 450
    PNTYVKLTLL NSMGQEMSKC KTSTRRGQPN PVYKETFVFQ VALFQLSDVT 500
    LILSVYNRRS MKRKEMIGWI SLGLNSSGEE ELRHWTAMKE SKGQQVCRWH 550
    ALLES 555
    Length:555
    Mass (Da):62,044
    Last modified:October 1, 2003 - v1
    Checksum:i7728CA866BFBA84E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB102947 mRNA. Translation: BAC76808.1.
    CCDSiCCDS48489.1.
    RefSeqiNP_853524.1. NM_181546.2.
    UniGeneiMm.170401.
    Mm.76710.

    Genome annotation databases

    EnsembliENSMUST00000016344; ENSMUSP00000016344; ENSMUSG00000016200.
    GeneIDi329324.
    KEGGimmu:329324.
    UCSCiuc007edu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB102947 mRNA. Translation: BAC76808.1 .
    CCDSi CCDS48489.1.
    RefSeqi NP_853524.1. NM_181546.2.
    UniGenei Mm.170401.
    Mm.76710.

    3D structure databases

    ProteinModelPortali Q7TN84.
    SMRi Q7TN84. Positions 259-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997547.
    STRINGi 10090.ENSMUSP00000016344.

    PTM databases

    PhosphoSitei Q7TN84.

    Proteomic databases

    PRIDEi Q7TN84.

    Protocols and materials databases

    DNASUi 329324.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016344 ; ENSMUSP00000016344 ; ENSMUSG00000016200 .
    GeneIDi 329324.
    KEGGi mmu:329324.
    UCSCi uc007edu.1. mouse.

    Organism-specific databases

    CTDi 255928.
    MGIi MGI:2444490. Syt14.

    Phylogenomic databases

    eggNOGi NOG305739.
    GeneTreei ENSGT00560000077240.
    HOVERGENi HBG062897.
    InParanoidi Q7TN84.
    OMAi GDSKCEF.
    OrthoDBi EOG7DRJ31.
    PhylomeDBi Q7TN84.
    TreeFami TF351132.

    Miscellaneous databases

    NextBioi 398680.
    PROi Q7TN84.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TN84.
    CleanExi MM_SYT14.
    Genevestigatori Q7TN84.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR028696. SYT14.
    [Graphical view ]
    PANTHERi PTHR10024:SF209. PTHR10024:SF209. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans."
      Fukuda M.
      J. Biochem. 133:641-649(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
    2. "Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation."
      Doi H., Yoshida K., Yasuda T., Fukuda M., Fukuda Y., Morita H., Ikeda S., Kato R., Tsurusaki Y., Miyake N., Saitsu H., Sakai H., Miyatake S., Shiina M., Nukina N., Koyano S., Tsuji S., Kuroiwa Y., Matsumoto N.
      Am. J. Hum. Genet. 89:320-327(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSYT14_MOUSE
    AccessioniPrimary (citable) accession number: Q7TN84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3