Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-coenzyme A synthetase ACSM4, mitochondrial

Gene

Acsm4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).1 Publication

Catalytic activityi

ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei455 – 4551ATPBy similarity
Binding sitei470 – 4701ATPBy similarity
Binding sitei566 – 5661ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2379ATPBy similarity
Nucleotide bindingi368 – 3736ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • butyrate-CoA ligase activity Source: UniProtKB-EC
  • fatty-acyl-CoA synthase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • odorant binding Source: RGD

GO - Biological processi

  • acyl-CoA metabolic process Source: RGD
  • fatty acid metabolic process Source: UniProtKB-KW
  • sensory perception of smell Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Chemistry

SwissLipidsiSLP:000001211.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC:6.2.1.2)
Alternative name(s):
Olfactory specific medium-chain acyl CoA synthetase
Short name:
O-MACS
Gene namesi
Name:Acsm4
Synonyms:Omacs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi727928. Acsm4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence analysisAdd
BLAST
Chaini23 – 580558Acyl-coenzyme A synthetase ACSM4, mitochondrialPRO_0000306105Add
BLAST

Proteomic databases

PaxDbiQ7TN78.
PRIDEiQ7TN78.

Expressioni

Tissue specificityi

Detected in adult olfactory epithelium.1 Publication

Developmental stagei

Detected in all cell layers of the dorso-medial part of the embryonic olfactory placode and olfactory epithelium. First detected in olfactory placode on embryonic day 11.5. Detected in olfactory placode on embryonic day 12, 14, 16 and 18.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031354.

Structurei

3D structure databases

ProteinModelPortaliQ7TN78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ7TN78.
KOiK01896.
OMAiAHRAKKF.
OrthoDBiEOG7D85VZ.
PhylomeDBiQ7TN78.
TreeFamiTF354287.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TN78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLRCQRL RFIWLAKPAG RHFHRDPQLW APLTLDDFEA INRCEKPLPK
60 70 80 90 100
NFNFAADVLD QWSLKEKSGE RPANPALWWV NGKGDEVKWS FQELGSLSRK
110 120 130 140 150
AANVLTKPCG LQRGDRVAVI LPRIPEWWLI NVACMRTGLV FMPGTIQLTR
160 170 180 190 200
KDILYRLQAS KAKCIVASEE VAPAVDSIAS ECPNLKTKLL VSPHRWDGWL
210 220 230 240 250
SFQELLQSAS EEHNCVQTGS QEPMAIYFTS GTTGSPKMAQ HSQSSLGIGY
260 270 280 290 300
ALCGRYWLDL TSSDIMWNMS DTGWIKAAIG SVFSTWLRGA CVFVHRMAQF
310 320 330 340 350
NTDTFLDTLT SYPITTLCSA PTVYRMLVQQ DLKRYQFKRL RHCLTGGEPL
360 370 380 390 400
NPEVLEQWKA QTGLELYEGY GQTEVGIICA NRKGEEIKPG SMGKGVVPYD
410 420 430 440 450
VQIIDEHGNI LPSGKEGEIA LRLGSDRPFC FFSEYVDNPE KTDATIRRNF
460 470 480 490 500
YITGDRGVMD DDGYLWFVGR ADDVIISSGY RIGPFEVESA LIEHPAVVES
510 520 530 540 550
AVVSSPDPIR GEVVKAFIVL AAPFKSSNRE KLTAELQDHV KNSTAPYKYP
560 570 580
RKVEFVQELP KTITGKIKRN VLRDQEWGRA
Length:580
Mass (Da):65,317
Last modified:October 1, 2003 - v1
Checksum:iD9556CB46AAAB7C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096688 mRNA. Translation: BAC77614.1.
RefSeqiNP_859046.1. NM_181695.1.
UniGeneiRn.162462.

Genome annotation databases

EnsembliENSRNOT00000034610; ENSRNOP00000031354; ENSRNOG00000014726.
GeneIDi353317.
KEGGirno:353317.
UCSCiRGD:727928. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096688 mRNA. Translation: BAC77614.1.
RefSeqiNP_859046.1. NM_181695.1.
UniGeneiRn.162462.

3D structure databases

ProteinModelPortaliQ7TN78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031354.

Chemistry

SwissLipidsiSLP:000001211.

Proteomic databases

PaxDbiQ7TN78.
PRIDEiQ7TN78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034610; ENSRNOP00000031354; ENSRNOG00000014726.
GeneIDi353317.
KEGGirno:353317.
UCSCiRGD:727928. rat.

Organism-specific databases

CTDi341392.
RGDi727928. Acsm4.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ7TN78.
KOiK01896.
OMAiAHRAKKF.
OrthoDBiEOG7D85VZ.
PhylomeDBiQ7TN78.
TreeFamiTF354287.

Miscellaneous databases

NextBioi672684.
PROiQ7TN78.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner."
    Oka Y., Kobayakawa K., Nishizumi H., Miyamichi K., Hirose S., Tsuboi A., Sakano H.
    Eur. J. Biochem. 270:1995-2004(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiACSM4_RAT
AccessioniPrimary (citable) accession number: Q7TN78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2003
Last modified: December 9, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.