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Protein
Submitted name:

Neurabin I

Gene

Ppp1r9a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurabin IImported
Submitted name:
Neural tissue-specific F-actin binding proteinImported
Submitted name:
Protein Ppp1r9aImported
Submitted name:
Protein phosphatase 1, regulatory (Inhibitor) subunit 9A, isoform CRA_cImported
Gene namesi
Name:Ppp1r9aImported
Synonyms:NeurabinImported
ORF Names:mCG_141520Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2442401. Ppp1r9a.

Subcellular locationi

GO - Cellular componenti

  • cortical actin cytoskeleton Source: MGI
  • cytoskeleton Source: MGI
  • cytosol Source: Ensembl
  • dendritic spine Source: MGI
  • dendritic spine neck Source: Ensembl
  • filopodium Source: MGI
  • growth cone Source: MGI
  • growth cone lamellipodium Source: Ensembl
  • neuromuscular junction Source: Ensembl
  • neuronal cell body Source: Ensembl
  • postsynaptic density Source: Ensembl
Complete GO annotation...

PTM / Processingi

PTM databases

iPTMnetiQ7TN74.

Expressioni

Gene expression databases

ExpressionAtlasiQ7TN74. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ7TN74. 1 interaction.
MINTiMINT-4600266.
STRINGi10090.ENSMUSP00000046906.

Structurei

3D structure databases

SMRiQ7TN74. Positions 436-594, 986-1056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini505 – 59389PDZ (DHR)InterPro annotationAdd
BLAST
Domaini989 – 105264SAM (sterile alpha motif)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili601 – 62828Sequence analysisAdd
BLAST
Coiled coili681 – 73656Sequence analysisAdd
BLAST
Coiled coili744 – 77835Sequence analysisAdd
BLAST
Coiled coili785 – 82440Sequence analysisAdd
BLAST
Coiled coili1039 – 108345Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1945. Eukaryota.
ENOG410Y7F2. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000252962.
HOVERGENiHBG005213.
KOiK17551.
PhylomeDBiQ7TN74.
TreeFamiTF105540.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR029994. Neurabin-1.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR16154:SF22. PTHR16154:SF22. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG
60 70 80 90 100
SQQSRGRKYG SNVNRIKNLF MQMGMEPSEN AAIIAKTRGK GRPSSPQRRM
110 120 130 140 150
KPKEFVEKTD GSVVKLESSV SERISRFDTM HDGPSYAKFT ETRKMFERSV
160 170 180 190 200
HESGQNHRYS PKKEKGGGTE PQDEWGGSKS NRGSSDSLDS LSPRTEAVSP
210 220 230 240 250
TVSQLSAVFE NSEPPGALTS GKAESADYSV TGHYPLNLPS VTVTNLDTFG
260 270 280 290 300
RLKDSNSKPP SNKQDTDTED AQKSDAVPVP EVAQKGTSLA SLPSEESQLS
310 320 330 340 350
TEAEDVTTAQ PEALDSTDKD SPEEPSAENQ AMPKSHILSP RNEPLEDAEA
360 370 380 390 400
NVVGSERAQH QKKDLTGGDL TSPDASASSC GREVPEDSNS FESSHVYMHS
410 420 430 440 450
DYNVYRVRSR YNSDWGETGT EQDEEEDSDE NNYYQPDMEY SEIVGLPEEE
460 470 480 490 500
EIPANRKIKF SCAPIKVFNT YSNEDYDRRN DDVDPVAASA EYELEKRVEK
510 520 530 540 550
LELFPVELEK DEDGLGISII GMGVGADAGL EKLGIFVKTV TDGGAAQRDG
560 570 580 590 600
RIQVNDQIVE VDGISLVGVT QNFAATVLRN TKGNVRFVIG REKPGQVSEV
610 620 630 640 650
AQLISQTLEQ ERRQRELLER HYAQYDADDD ETGEYATDEE EDEGGPILPS
660 670 680 690 700
GDVAIEVFEL PENEDMFSPS DLDTSKLSHK FKELQIKHAV TEAEIQKLKT
710 720 730 740 750
KLQAAENEKV RWELEKNQLQ QNIEENKERM LKLESYWIEA QTLCHTVNEH
760 770 780 790 800
LKETQSQYQA LEKKYNKAKK LIKDFQQKEL DFIKRQEVER KKREEVEKAH
810 820 830 840 850
LLEVQGLQVR IRDLEAEVFR LLKQNGTQVN NNNNIFERRP SPGEVSKGDT
860 870 880 890 900
MENVEVKQTS CQDGLSQDLN EAVPETERLD SKALKTRAQL SVKNRRQRPT
910 920 930 940 950
RTRLYDSVSS TDGEDSLERK NFTFNDDFSP SSTSSADLSG LGAEPKTPGL
960 970 980 990 1000
SQSLALSSDE SLDMIDDEIL DDGQSPKHTQ SQNRAVHEWS VQQVSHWLMS
1010 1020 1030 1040 1050
LSLDQYVPEF SAQSISGEQL LQLDGNKLKA LGMTSSQDRA LVKKKLKEMK
1060 1070 1080 1090
MSLEKARKAQ EKMEKQREKL RRKEQEQMQR KSKKSEKMTS TADQP
Length:1,095
Mass (Da):122,955
Last modified:October 1, 2003 - v1
Checksum:i3F207AADEC2E5010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068500 Genomic DNA. No translation available.
AC074225 Genomic DNA. No translation available.
AY308065 mRNA. Translation: AAQ77229.1.
AB091828 mRNA. Translation: BAC77245.1.
CH466533 Genomic DNA. Translation: EDL13976.1.
RefSeqiNP_853626.1. NM_181595.3.
XP_006505142.1. XM_006505079.2.
UniGeneiMm.332901.

Genome annotation databases

EnsembliENSMUST00000035813; ENSMUSP00000046906; ENSMUSG00000032827.
GeneIDi243725.
KEGGimmu:243725.
UCSCiuc009avx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068500 Genomic DNA. No translation available.
AC074225 Genomic DNA. No translation available.
AY308065 mRNA. Translation: AAQ77229.1.
AB091828 mRNA. Translation: BAC77245.1.
CH466533 Genomic DNA. Translation: EDL13976.1.
RefSeqiNP_853626.1. NM_181595.3.
XP_006505142.1. XM_006505079.2.
UniGeneiMm.332901.

3D structure databases

SMRiQ7TN74. Positions 436-594, 986-1056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TN74. 1 interaction.
MINTiMINT-4600266.
STRINGi10090.ENSMUSP00000046906.

PTM databases

iPTMnetiQ7TN74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035813; ENSMUSP00000046906; ENSMUSG00000032827.
GeneIDi243725.
KEGGimmu:243725.
UCSCiuc009avx.1. mouse.

Organism-specific databases

CTDi55607.
MGIiMGI:2442401. Ppp1r9a.

Phylogenomic databases

eggNOGiKOG1945. Eukaryota.
ENOG410Y7F2. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000252962.
HOVERGENiHBG005213.
KOiK17551.
PhylomeDBiQ7TN74.
TreeFamiTF105540.

Miscellaneous databases

ChiTaRSiPpp1r9a. mouse.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ7TN74. baseline and differential.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR029994. Neurabin-1.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR16154:SF22. PTHR16154:SF22. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6."
    Ono R., Shiura H., Aburatani H., Kohda T., Kaneko-Ishino T., Ishino F.
    Genome Res. 13:1696-1705(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL6Imported.
  3. "Genomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle tissues and extra-embryonic tissues."
    Nakabayashi K., Makino S., Minagawa S., Smith A.C., Bamforth J.S., Stanier P., Preece M., Oshimura M., Yoshikawa Y., Hui C.C., Moore G.E., Scherer S.W.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ7TN74_MOUSE
AccessioniPrimary (citable) accession number: Q7TN74
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.