Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7TN58

- TMC8_MOUSE

UniProt

Q7TN58 - TMC8_MOUSE

Protein

Transmembrane channel-like protein 8

Gene

Tmc8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable ion channel.By similarity

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi1.A.17.4.2. the calcium-dependent chloride channel (ca-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane channel-like protein 8
    Alternative name(s):
    Epidermodysplasia verruciformis protein 2 homolog
    Gene namesi
    Name:Tmc8
    Synonyms:Ever2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2669037. Tmc8.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 722722Transmembrane channel-like protein 8PRO_0000185387Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7TN58.
    PRIDEiQ7TN58.

    PTM databases

    PhosphoSiteiQ7TN58.

    Expressioni

    Tissue specificityi

    Expressed in thymus, lung, prostate, placenta, testis and spleen.2 Publications

    Gene expression databases

    ArrayExpressiQ7TN58.
    BgeeiQ7TN58.
    CleanExiMM_TMC8.
    GenevestigatoriQ7TN58.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 118118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini140 – 20465LumenalSequence AnalysisAdd
    BLAST
    Topological domaini226 – 30782CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 37547LumenalSequence AnalysisAdd
    BLAST
    Topological domaini397 – 43034CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini452 – 49241LumenalSequence AnalysisAdd
    BLAST
    Topological domaini514 – 53623CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini558 – 59841LumenalSequence AnalysisAdd
    BLAST
    Topological domaini620 – 722103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei537 – 55721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei599 – 61921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMC family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70493.
    GeneTreeiENSGT00670000097979.
    HOGENOMiHOG000038033.
    HOVERGENiHBG055908.
    OMAiWCVVLKL.
    OrthoDBiEOG73FQM9.
    TreeFamiTF313462.

    Family and domain databases

    InterProiIPR012496. TMC.
    [Graphical view]
    PfamiPF07810. TMC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TN58-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFRQWSVQSG PAPRRPESQA ASEELWEQEV ERLCASRTPV RMLPYAMADK    50
    RFIRELREPE GVKTTFWQRW HRPRRVARQH LREAEQRLAR GFGLWEGALY 100
    EIGGLFGTGI QSYFTFLRFL LLLNLLTMLL TACFVLLPLV WLRPPELGPA 150
    LKLRLQCSSS PLPQSDIPRF HNPLWNILTG RAFNNTYLFY GAYRAGPESS 200
    SEYSIRLAYL LSPMVCLLLC FCGILQRMAE GLPQQTLLGQ RYRTPLSAKV 250
    FSSWDFCIRV WEAATIKKHE ISNELKMELE EGRRVELAQQ QTRAQKACRL 300
    LTYLRTNILI VLLVVGAISA IFWATKYSQD NKEESLFLVL QYLPPGVISL 350
    VNFLGPQLFT VLIQLENYPP GTEVNLTLIW CVVLKLASLG MFSFSLGQTV 400
    LCIGRNKTSC ESYGYNACDY QCWENSVGEE LYKLIIFNFL LTVAFAFLVS 450
    LPRRLLVERF SGWFWTWLDR EEFLVPKNVL DIVAAQTVTW MGLFYCPLLP 500
    LLNSVFLFLT FYIKKYTLLR NSRASPRRFR ASSSTFFFHL VLLLGLLLAA 550
    VPLAYVISST HSSWDCGLFT NYSAPWQVVP ELVALQLPLP SQRALRYLSS 600
    HAFSFPLLIL LSIVLTVCIS QSRANARAIQ GLRKQLVWQV QEKWHLVDDL 650
    SRLLPELSPE PGSPHSRASR PRSFCPGFPC PGSPGPRTPR LAPSNRLSSS 700
    SLGAPSASVP ASRFHFPSRT EL 722
    Length:722
    Mass (Da):82,329
    Last modified:December 6, 2005 - v2
    Checksum:i33799843E88B6FD9
    GO
    Isoform 2 (identifier: Q7TN58-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-154: R → TG

    Note: No experimental confirmation available.

    Show »
    Length:723
    Mass (Da):82,331
    Checksum:i373EF46922479C5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791T → A in BAE42658. (PubMed:16141072)Curated
    Sequence conflicti277 – 2782ME → VC in AAP69879. (PubMed:12906855)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei154 – 1541R → TG in isoform 2. 1 PublicationVSP_016451

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236501 mRNA. Translation: AAP69879.1.
    AY263160 mRNA. Translation: AAP78775.1.
    AK136329 mRNA. Translation: BAE22935.1.
    AK171772 mRNA. Translation: BAE42658.1.
    CCDSiCCDS25689.1. [Q7TN58-1]
    CCDS56824.1. [Q7TN58-2]
    RefSeqiNP_001182019.1. NM_001195090.1.
    NP_862904.1. NM_181856.2. [Q7TN58-1]
    XP_006533187.1. XM_006533124.1. [Q7TN58-1]
    UniGeneiMm.116675.

    Genome annotation databases

    EnsembliENSMUST00000050874; ENSMUSP00000051878; ENSMUSG00000050106. [Q7TN58-1]
    ENSMUST00000106334; ENSMUSP00000101941; ENSMUSG00000050106. [Q7TN58-2]
    ENSMUST00000119455; ENSMUSP00000113628; ENSMUSG00000050106. [Q7TN58-2]
    GeneIDi217356.
    KEGGimmu:217356.
    UCSCiuc007mns.2. mouse. [Q7TN58-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236501 mRNA. Translation: AAP69879.1 .
    AY263160 mRNA. Translation: AAP78775.1 .
    AK136329 mRNA. Translation: BAE22935.1 .
    AK171772 mRNA. Translation: BAE42658.1 .
    CCDSi CCDS25689.1. [Q7TN58-1 ]
    CCDS56824.1. [Q7TN58-2 ]
    RefSeqi NP_001182019.1. NM_001195090.1.
    NP_862904.1. NM_181856.2. [Q7TN58-1 ]
    XP_006533187.1. XM_006533124.1. [Q7TN58-1 ]
    UniGenei Mm.116675.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.A.17.4.2. the calcium-dependent chloride channel (ca-clc) family.

    PTM databases

    PhosphoSitei Q7TN58.

    Proteomic databases

    PaxDbi Q7TN58.
    PRIDEi Q7TN58.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050874 ; ENSMUSP00000051878 ; ENSMUSG00000050106 . [Q7TN58-1 ]
    ENSMUST00000106334 ; ENSMUSP00000101941 ; ENSMUSG00000050106 . [Q7TN58-2 ]
    ENSMUST00000119455 ; ENSMUSP00000113628 ; ENSMUSG00000050106 . [Q7TN58-2 ]
    GeneIDi 217356.
    KEGGi mmu:217356.
    UCSCi uc007mns.2. mouse. [Q7TN58-1 ]

    Organism-specific databases

    CTDi 147138.
    MGIi MGI:2669037. Tmc8.

    Phylogenomic databases

    eggNOGi NOG70493.
    GeneTreei ENSGT00670000097979.
    HOGENOMi HOG000038033.
    HOVERGENi HBG055908.
    OMAi WCVVLKL.
    OrthoDBi EOG73FQM9.
    TreeFami TF313462.

    Miscellaneous databases

    ChiTaRSi TMC8. mouse.
    NextBioi 375807.
    PROi Q7TN58.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TN58.
    Bgeei Q7TN58.
    CleanExi MM_TMC8.
    Genevestigatori Q7TN58.

    Family and domain databases

    InterProi IPR012496. TMC.
    [Graphical view ]
    Pfami PF07810. TMC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis."
      Kurima K., Yang Y., Sorber K., Griffith A.J.
      Genomics 82:300-308(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins."
      Keresztes G., Mutai H., Heller S.
      BMC Genomics 4:24-24(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Strain: C57BL/6.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-722.
      Strain: C57BL/6J.
      Tissue: Testis.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiTMC8_MOUSE
    AccessioniPrimary (citable) accession number: Q7TN58
    Secondary accession number(s): Q3TAL0, Q3UWI0, Q7TQ67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3