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Protein

Mas-related G-protein coupled receptor member A

Gene

Mrgpra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member A
Gene namesi
Name:Mrgpra
Synonyms:Mrga
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi738050. Mrgpra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence analysisAdd
BLAST
Transmembranei18 – 3821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini39 – 468CytoplasmicSequence analysis
Transmembranei47 – 6721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini68 – 8013ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini102 – 13231CytoplasmicSequence analysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini154 – 16714ExtracellularSequence analysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini189 – 21123CytoplasmicSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini233 – 24412ExtracellularSequence analysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini266 – 30439CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Mas-related G-protein coupled receptor member APRO_0000069755Add
BLAST

Proteomic databases

PaxDbiQ7TN49.
PRIDEiQ7TN49.

Expressioni

Tissue specificityi

Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.1 Publication

Gene expression databases

GenevisibleiQ7TN49. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019051.

Structurei

3D structure databases

ProteinModelPortaliQ7TN49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ7TN49.
KOiK08396.
OMAiGGINITI.
OrthoDBiEOG73Z2V2.
PhylomeDBiQ7TN49.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026233. MRGPCRA.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02109. MRGPCRA.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTIPGSFN SRTLIPNLLI IISGLVGLIG NAMVFWLLGF RLARNAFSVY
60 70 80 90 100
ILNLALADFL FLLCHIIDST LLLLKFSYPN IIFLPCFNTV MMVPYIAGLS
110 120 130 140 150
MLSAISTERC LSVVCPIWYR CRRPKHTSTV MCSAIWVLSL LICILNRYFC
160 170 180 190 200
GFLDTKYEKD NRCLASNFFT AACLIFLFVV LCLSSLALLV RLFCGAGRMK
210 220 230 240 250
LTRLYATIML TVLVFLLCGL PFGIHWFLLI WIKIDYGKFA YGLYLAALVL
260 270 280 290 300
TAVNSCANPI IYFFVGSFRH QKHQTLKMVL QRALQDTPET AENTVEMSSS

KVEP
Length:304
Mass (Da):34,346
Last modified:October 23, 2007 - v2
Checksum:i4541FA4B35AC18BF
GO

Sequence cautioni

The sequence AAH89774.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC84592.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111S → G in CAC84592 (PubMed:12084918).Curated
Sequence conflicti29 – 291I → T in AAQ08310 (PubMed:12909716).Curated
Sequence conflicti192 – 1921L → S in CAC84592 (PubMed:12084918).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311952 mRNA. Translation: CAC84592.1. Different initiation.
AF518238 Genomic DNA. Translation: AAQ08310.1.
BC089774 mRNA. Translation: AAH89774.1. Different initiation.
RefSeqiNP_665730.2. NM_145787.2.
UniGeneiRn.81069.

Genome annotation databases

GeneIDi252960.
KEGGirno:252960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311952 mRNA. Translation: CAC84592.1. Different initiation.
AF518238 Genomic DNA. Translation: AAQ08310.1.
BC089774 mRNA. Translation: AAH89774.1. Different initiation.
RefSeqiNP_665730.2. NM_145787.2.
UniGeneiRn.81069.

3D structure databases

ProteinModelPortaliQ7TN49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019051.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ7TN49.
PRIDEiQ7TN49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi252960.
KEGGirno:252960.

Organism-specific databases

CTDi117195.
RGDi738050. Mrgpra.

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ7TN49.
KOiK08396.
OMAiGGINITI.
OrthoDBiEOG73Z2V2.
PhylomeDBiQ7TN49.
TreeFamiTF336336.

Miscellaneous databases

NextBioi624138.
PROiQ7TN49.

Gene expression databases

GenevisibleiQ7TN49. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026233. MRGPCRA.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02109. MRGPCRA.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule."
    Bender E., Buist A., Jurzak M., Langlois X., Baggerman G., Verhasselt P., Ercken M., Guo H.-Q., Wintmolders C., Van den Wyngaert I., Van Oers I., Schoofs L., Luyten W.
    Proc. Natl. Acad. Sci. U.S.A. 99:8573-8578(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."
    Zylka M.J., Dong X., Southwell A.L., Anderson D.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMRGRA_RAT
AccessioniPrimary (citable) accession number: Q7TN49
Secondary accession number(s): Q5FVU1, Q91YB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be an adenine receptor but PubMed:12397184 found no activation by adenine of the mouse ortholog.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.