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Protein

Mas-related G-protein coupled receptor member D

Gene

Mrgprd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member D
Alternative name(s):
Beta-alanine receptor
G-protein coupled receptor TGR7
Gene namesi
Name:Mrgprd
Synonyms:Mrgd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi738040. Mrgprd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6413CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini86 – 927ExtracellularSequence analysis
Transmembranei93 – 11321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini114 – 14431CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 18419ExtracellularSequence analysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini206 – 22015CytoplasmicSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini242 – 26019ExtracellularSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini282 – 31938CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Mas-related G-protein coupled receptor member DPRO_0000069759Add
BLAST

Proteomic databases

PaxDbiQ7TN41.
PRIDEiQ7TN41.

Expressioni

Tissue specificityi

Co-expressed in the small diameter neurons with P2X3 and VR1 in dorsal root ganglia.1 Publication

Gene expression databases

ExpressionAtlasiQ7TN41. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ7TN41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ7TN41.
KOiK08392.
OMAiPSTCTND.
OrthoDBiEOG78SQJK.
PhylomeDBiQ7TN41.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTPYSSPA PGLTISPTMD PVTWVYFSVT FLAMATCVCG IVGNSMVIWL
60 70 80 90 100
LSFHRVQRSP FCTYVLNLAV ADLLFLLCMA SLLSLETGPL LTASTSARVY
110 120 130 140 150
EGMKRIKYFA YTAGLSLLTA ISTQRCLSVL FPIWYKCHRP QHLSGVVCGV
160 170 180 190 200
LWALALLMNF LASFFCVQFW HPDKYQCFKV DMVFNSLILG IFMPVMVLTS
210 220 230 240 250
AIIFIRMRKN SLLQRRQPRR LYVVILTSVL VFLTCSLPLG INWFLLYWVE
260 270 280 290 300
LPQAVRLLYV CSSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
310
LQDEPEGRET PSTCTNDGV
Length:319
Mass (Da):35,830
Last modified:October 1, 2003 - v1
Checksum:i500F41492DE002F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551R → S in BAD20639 (PubMed:15037633).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518246 Genomic DNA. Translation: AAQ08318.1.
AB154411 mRNA. Translation: BAD20639.1.
RefSeqiNP_001001506.1. NM_001001506.1.
XP_006230787.1. XM_006230725.2.
UniGeneiRn.162482.

Genome annotation databases

EnsembliENSRNOT00000017958; ENSRNOP00000017958; ENSRNOG00000013448.
GeneIDi293648.
KEGGirno:293648.
UCSCiRGD:738040. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518246 Genomic DNA. Translation: AAQ08318.1.
AB154411 mRNA. Translation: BAD20639.1.
RefSeqiNP_001001506.1. NM_001001506.1.
XP_006230787.1. XM_006230725.2.
UniGeneiRn.162482.

3D structure databases

ProteinModelPortaliQ7TN41.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi152.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ7TN41.
PRIDEiQ7TN41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017958; ENSRNOP00000017958; ENSRNOG00000013448.
GeneIDi293648.
KEGGirno:293648.
UCSCiRGD:738040. rat.

Organism-specific databases

CTDi116512.
RGDi738040. Mrgprd.

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ7TN41.
KOiK08392.
OMAiPSTCTND.
OrthoDBiEOG78SQJK.
PhylomeDBiQ7TN41.
TreeFamiTF336336.

Miscellaneous databases

PROiQ7TN41.

Gene expression databases

ExpressionAtlasiQ7TN41. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."
    Zylka M.J., Dong X., Southwell A.L., Anderson D.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-Dawley.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Cerebellum.

Entry informationi

Entry nameiMRGRD_RAT
AccessioniPrimary (citable) accession number: Q7TN41
Secondary accession number(s): Q6L788
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.