ID   MRGRE_RAT               Reviewed;         309 AA.
AC   Q7TN40;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   19-JAN-2010, entry version 47.
DE   RecName: Full=Mas-related G-protein coupled receptor member E;
GN   Name=Mrgpre; Synonyms=Mrge;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=22810130; PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G
RT   protein-coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
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DR   EMBL; AF518247; AAQ08319.1; -; Genomic_DNA.
DR   IPI; IPI00454481; -.
DR   RefSeq; NP_001002288.1; -.
DR   UniGene; Rn.189891; -.
DR   SMR; Q7TN40; 27-293.
DR   Ensembl; ENSRNOT00000028129; ENSRNOP00000028129; ENSRNOG00000020735; Rattus norvegicus.
DR   GeneID; 404660; -.
DR   KEGG; rno:404660; -.
DR   CTD; 404660; -.
DR   RGD; 738045; Mrgpre.
DR   eggNOG; maNOG18352; -.
DR   HOVERGEN; Q7TN40; -.
DR   InParanoid; Q7TN40; -.
DR   OMA; DVACADL; -.
DR   OrthoDB; EOG9KD96C; -.
DR   PhylomeDB; Q7TN40; -.
DR   NextBio; 692778; -.
DR   Genevestigator; Q7TN40; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; TAS:RGD.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Transducer; Transmembrane.
FT   CHAIN         1    309       Mas-related G-protein coupled receptor
FT                                member E.
FT                                /FTId=PRO_0000069763.
FT   TOPO_DOM      1     21       Extracellular (Potential).
FT   TRANSMEM     22     42       1 (Potential).
FT   TOPO_DOM     43     59       Cytoplasmic (Potential).
FT   TRANSMEM     60     80       2 (Potential).
FT   TOPO_DOM     81     91       Extracellular (Potential).
FT   TRANSMEM     92    112       3 (Potential).
FT   TOPO_DOM    113    132       Cytoplasmic (Potential).
FT   TRANSMEM    133    153       4 (Potential).
FT   TOPO_DOM    154    168       Extracellular (Potential).
FT   TRANSMEM    169    189       5 (Potential).
FT   TOPO_DOM    190    212       Cytoplasmic (Potential).
FT   TRANSMEM    213    233       6 (Potential).
FT   TOPO_DOM    234    247       Extracellular (Potential).
FT   TRANSMEM    248    268       7 (Potential).
FT   TOPO_DOM    269    309       Cytoplasmic (Potential).
FT   CARBOHYD     19     19       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    236    236       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   309 AA;  34511 MW;  20F0424940FB9781 CRC64;
     MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR NPFSIYLLDV
     ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF CYIVGLSLLV AISTEQCLAT
     LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD LLLSGACTQF FGAPSYHLCG MLWLVVAVLL
     AALCCTMCVT SLLLLLRVER GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH
     TPLYFYHFSF FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS
     QGGLVDMTV
//