ID   MRGRE_RAT               Reviewed;         309 AA.
AC   Q7TN40;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   16-NOV-2011, entry version 59.
DE   RecName: Full=Mas-related G-protein coupled receptor member E;
GN   Name=Mrgpre; Synonyms=Mrge;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=22810130; PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G
RT   protein-coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
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DR   EMBL; AF518247; AAQ08319.1; -; Genomic_DNA.
DR   IPI; IPI00454481; -.
DR   RefSeq; NP_001002288.1; NM_001002288.1.
DR   UniGene; Rn.189891; -.
DR   ProteinModelPortal; Q7TN40; -.
DR   STRING; Q7TN40; -.
DR   Ensembl; ENSRNOT00000028129; ENSRNOP00000028129; ENSRNOG00000020735.
DR   GeneID; 404660; -.
DR   KEGG; rno:404660; -.
DR   CTD; 116534; -.
DR   RGD; 738045; Mrgpre.
DR   eggNOG; maNOG18352; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   HOVERGEN; HBG102287; -.
DR   InParanoid; Q7TN40; -.
DR   OMA; DVACADL; -.
DR   OrthoDB; EOG4NVZM3; -.
DR   PhylomeDB; Q7TN40; -.
DR   NextBio; 692778; -.
DR   Genevestigator; Q7TN40; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; TAS:RGD.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   KO; K08393; -.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    309       Mas-related G-protein coupled receptor
FT                                member E.
FT                                /FTId=PRO_0000069763.
FT   TOPO_DOM      1     21       Extracellular (Potential).
FT   TRANSMEM     22     42       Helical; Name=1; (Potential).
FT   TOPO_DOM     43     59       Cytoplasmic (Potential).
FT   TRANSMEM     60     80       Helical; Name=2; (Potential).
FT   TOPO_DOM     81     91       Extracellular (Potential).
FT   TRANSMEM     92    112       Helical; Name=3; (Potential).
FT   TOPO_DOM    113    132       Cytoplasmic (Potential).
FT   TRANSMEM    133    153       Helical; Name=4; (Potential).
FT   TOPO_DOM    154    168       Extracellular (Potential).
FT   TRANSMEM    169    189       Helical; Name=5; (Potential).
FT   TOPO_DOM    190    212       Cytoplasmic (Potential).
FT   TRANSMEM    213    233       Helical; Name=6; (Potential).
FT   TOPO_DOM    234    247       Extracellular (Potential).
FT   TRANSMEM    248    268       Helical; Name=7; (Potential).
FT   TOPO_DOM    269    309       Cytoplasmic (Potential).
FT   CARBOHYD     19     19       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    236    236       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   309 AA;  34511 MW;  20F0424940FB9781 CRC64;
     MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR NPFSIYLLDV
     ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF CYIVGLSLLV AISTEQCLAT
     LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD LLLSGACTQF FGAPSYHLCG MLWLVVAVLL
     AALCCTMCVT SLLLLLRVER GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH
     TPLYFYHFSF FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS
     QGGLVDMTV
//