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Protein

Mas-related G-protein coupled receptor member E

Gene

Mrgpre

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Gene namesi
Name:Mrgpre
Synonyms:Mrge
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi738045. Mrgpre.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 59CytoplasmicSequence analysisAdd BLAST17
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 91ExtracellularSequence analysisAdd BLAST11
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 132CytoplasmicSequence analysisAdd BLAST20
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 168ExtracellularSequence analysisAdd BLAST15
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 212CytoplasmicSequence analysisAdd BLAST23
Transmembranei213 – 233Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini234 – 247ExtracellularSequence analysisAdd BLAST14
Transmembranei248 – 268Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini269 – 309CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697631 – 309Mas-related G-protein coupled receptor member EAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7TN40.

PTM databases

iPTMnetiQ7TN40.
PhosphoSitePlusiQ7TN40.

Structurei

3D structure databases

ProteinModelPortaliQ7TN40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ7TN40.
KOiK08393.
OMAiTEQCLAT.
OrthoDBiEOG091G0GUJ.
PhylomeDBiQ7TN40.
TreeFamiTF336336.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR
60 70 80 90 100
NPFSIYLLDV ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF
110 120 130 140 150
CYIVGLSLLV AISTEQCLAT LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD
160 170 180 190 200
LLLSGACTQF FGAPSYHLCG MLWLVVAVLL AALCCTMCVT SLLLLLRVER
210 220 230 240 250
GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH TPLYFYHFSF
260 270 280 290 300
FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS

QGGLVDMTV
Length:309
Mass (Da):34,511
Last modified:October 1, 2003 - v1
Checksum:i20F0424940FB9781
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518247 Genomic DNA. Translation: AAQ08319.1.
RefSeqiNP_001002288.1. NM_001002288.1.
XP_006230932.1. XM_006230870.3.
XP_006230934.1. XM_006230872.3.
XP_008758385.1. XM_008760163.2.
XP_017445008.1. XM_017589519.1.
XP_017445009.1. XM_017589520.1.
UniGeneiRn.189891.

Genome annotation databases

EnsembliENSRNOT00000077911; ENSRNOP00000070110; ENSRNOG00000054917.
GeneIDi404660.
KEGGirno:404660.
UCSCiRGD:738045. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518247 Genomic DNA. Translation: AAQ08319.1.
RefSeqiNP_001002288.1. NM_001002288.1.
XP_006230932.1. XM_006230870.3.
XP_006230934.1. XM_006230872.3.
XP_008758385.1. XM_008760163.2.
XP_017445008.1. XM_017589519.1.
XP_017445009.1. XM_017589520.1.
UniGeneiRn.189891.

3D structure databases

ProteinModelPortaliQ7TN40.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ7TN40.
PhosphoSitePlusiQ7TN40.

Proteomic databases

PRIDEiQ7TN40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077911; ENSRNOP00000070110; ENSRNOG00000054917.
GeneIDi404660.
KEGGirno:404660.
UCSCiRGD:738045. rat.

Organism-specific databases

CTDi116534.
RGDi738045. Mrgpre.

Phylogenomic databases

GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ7TN40.
KOiK08393.
OMAiTEQCLAT.
OrthoDBiEOG091G0GUJ.
PhylomeDBiQ7TN40.
TreeFamiTF336336.

Miscellaneous databases

PROiQ7TN40.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGRE_RAT
AccessioniPrimary (citable) accession number: Q7TN40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.