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Reviewed, UniProtKB/Swiss-Prot Q7TN40 (MRGRE_RAT)

Last modified November 3, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Mas-related G-protein coupled receptor member E
Gene names
Name: Mrgpre
Synonyms: Mrge
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

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Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionG-protein coupled receptor activity Ref.1

Traceable author statement. Source: RGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Mas-related G-protein coupled receptor member E
PRO_0000069763

Regions

Topological domain1 – 2121Extracellular Potential
Transmembrane22 – 42211 Potential
Topological domain43 – 5917Cytoplasmic Potential
Transmembrane60 – 80212 Potential
Topological domain81 – 9111Extracellular Potential
Transmembrane92 – 112213 Potential
Topological domain113 – 13220Cytoplasmic Potential
Transmembrane133 – 153214 Potential
Topological domain154 – 16815Extracellular Potential
Transmembrane169 – 189215 Potential
Topological domain190 – 21223Cytoplasmic Potential
Transmembrane213 – 233216 Potential
Topological domain234 – 24714Extracellular Potential
Transmembrane248 – 268217 Potential
Topological domain269 – 30941Cytoplasmic Potential

Amino acid modifications

Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q7TN40-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 20F0424940FB9781

FASTA30934,511
        10         20         30         40         50         60 
MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR NPFSIYLLDV 

        70         80         90        100        110        120 
ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF CYIVGLSLLV AISTEQCLAT 

       130        140        150        160        170        180 
LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD LLLSGACTQF FGAPSYHLCG MLWLVVAVLL 

       190        200        210        220        230        240 
AALCCTMCVT SLLLLLRVER GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH 

       250        260        270        280        290        300 
TPLYFYHFSF FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS 


QGGLVDMTV

« Hide

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References

[1]"Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."
Zylka M.J., Dong X., Southwell A.L., Anderson D.J.
Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed: 12909716] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF518247 Genomic DNA. Translation: AAQ08319.1.
IPIIPI00454481.
RefSeqNP_001002288.1.
UniGeneRn.189891

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSRNOT00000028129; ENSRNOP00000028129; ENSRNOG00000020735; Rattus norvegicus. [Genome view]
GeneID404660.
KEGGrno:404660.

Organism-specific databases

CTD404660.
RGD738045. Mrgpre.

Phylogenomic databases

HOVERGENQ7TN40.
OMADVACADL.

Gene expression databases

GenevestigatorQ7TN40.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio692778.

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Entry information

Entry nameMRGRE_RAT
AccessionPrimary (citable) accession number: Q7TN40
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2003
Last modified: November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents