Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mas-related G-protein coupled receptor member E

Gene

Mrgpre

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Gene namesi
Name:Mrgpre
Synonyms:Mrge
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi738045. Mrgpre.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 5917CytoplasmicSequence analysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 9111ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 13220CytoplasmicSequence analysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini154 – 16815ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini190 – 21223CytoplasmicSequence analysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini234 – 24714ExtracellularSequence analysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini269 – 30941CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Mas-related G-protein coupled receptor member EPRO_0000069763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

PTM databases

iPTMnetiQ7TN40.

Structurei

3D structure databases

ProteinModelPortaliQ7TN40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ7TN40.
KOiK08393.
PhylomeDBiQ7TN40.
TreeFamiTF336336.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR
60 70 80 90 100
NPFSIYLLDV ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF
110 120 130 140 150
CYIVGLSLLV AISTEQCLAT LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD
160 170 180 190 200
LLLSGACTQF FGAPSYHLCG MLWLVVAVLL AALCCTMCVT SLLLLLRVER
210 220 230 240 250
GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH TPLYFYHFSF
260 270 280 290 300
FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS

QGGLVDMTV
Length:309
Mass (Da):34,511
Last modified:October 1, 2003 - v1
Checksum:i20F0424940FB9781
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518247 Genomic DNA. Translation: AAQ08319.1.
RefSeqiNP_001002288.1. NM_001002288.1.
XP_006230932.1. XM_006230870.2.
XP_006230934.1. XM_006230872.2.
XP_008758385.1. XM_008760163.1.
UniGeneiRn.189891.

Genome annotation databases

EnsembliENSRNOT00000077911; ENSRNOP00000070110; ENSRNOG00000054917.
GeneIDi404660.
KEGGirno:404660.
UCSCiRGD:738045. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518247 Genomic DNA. Translation: AAQ08319.1.
RefSeqiNP_001002288.1. NM_001002288.1.
XP_006230932.1. XM_006230870.2.
XP_006230934.1. XM_006230872.2.
XP_008758385.1. XM_008760163.1.
UniGeneiRn.189891.

3D structure databases

ProteinModelPortaliQ7TN40.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ7TN40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077911; ENSRNOP00000070110; ENSRNOG00000054917.
GeneIDi404660.
KEGGirno:404660.
UCSCiRGD:738045. rat.

Organism-specific databases

CTDi116534.
RGDi738045. Mrgpre.

Phylogenomic databases

HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ7TN40.
KOiK08393.
PhylomeDBiQ7TN40.
TreeFamiTF336336.

Miscellaneous databases

PROiQ7TN40.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."
    Zylka M.J., Dong X., Southwell A.L., Anderson D.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiMRGRE_RAT
AccessioniPrimary (citable) accession number: Q7TN40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.