Q7TN40 (MRGRE_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member E

Gene names

Name:	Mrgpre
Synonyms:	Mrge

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Mas-related G-protein coupled receptor member E		PRO_0000069763
Regions
	Topological domain	1 – 21	21	Extracellular Potential
	Transmembrane	22 – 42	21	Helical; Name=1; Potential
	Topological domain	43 – 59	17	Cytoplasmic Potential
	Transmembrane	60 – 80	21	Helical; Name=2; Potential
	Topological domain	81 – 91	11	Extracellular Potential
	Transmembrane	92 – 112	21	Helical; Name=3; Potential
	Topological domain	113 – 132	20	Cytoplasmic Potential
	Transmembrane	133 – 153	21	Helical; Name=4; Potential
	Topological domain	154 – 168	15	Extracellular Potential
	Transmembrane	169 – 189	21	Helical; Name=5; Potential
	Topological domain	190 – 212	23	Cytoplasmic Potential
	Transmembrane	213 – 233	21	Helical; Name=6; Potential
	Topological domain	234 – 247	14	Extracellular Potential
	Transmembrane	248 – 268	21	Helical; Name=7; Potential
	Topological domain	269 – 309	41	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Glycosylation	236	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7TN40 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 20F0424940FB9781	FASTA	309	34,511
	10 20 30 40 50 60 MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR NPFSIYLLDV 70 80 90 100 110 120 ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF CYIVGLSLLV AISTEQCLAT 130 140 150 160 170 180 LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD LLLSGACTQF FGAPSYHLCG MLWLVVAVLL 190 200 210 220 230 240 AALCCTMCVT SLLLLLRVER GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH 250 260 270 280 290 300 TPLYFYHFSF FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS QGGLVDMTV

References

[1]

"Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family." Zylka M.J., Dong X., Southwell A.L., Anderson D.J. Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed: 12909716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF518247 Genomic DNA. Translation: AAQ08319.1.
IPI	IPI00454481.
RefSeq	NP_001002288.1. NM_001002288.1.
UniGene	Rn.189891.
3D structure databases
ProteinModelPortal	Q7TN40.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7TN40.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000028129; ENSRNOP00000028129; ENSRNOG00000020735.
GeneID	404660.
KEGG	rno:404660.
Organism-specific databases
CTD	116534.
RGD	738045. Mrgpre.
Phylogenomic databases
eggNOG	maNOG18352.
GeneTree	ENSGT00550000074531.
HOVERGEN	HBG102287.
InParanoid	Q7TN40.
OMA	DVACADL.
OrthoDB	EOG4NVZM3.
PhylomeDB	Q7TN40.
Gene expression databases
Genevestigator	Q7TN40.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K08393.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	692778.

Entry information

Entry name

MRGRE_RAT

Accession

Primary (citable) accession number: Q7TN40

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	October 1, 2003
Last modified:	November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program