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Protein

Mas-related G-protein coupled receptor member G

Gene

Mrgprg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member G
Gene namesi
Name:Mrgprg
Synonyms:Mrgg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi738044. Mrgprg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313ExtracellularSequence analysisAdd
BLAST
Transmembranei14 – 3421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini35 – 4915CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini71 – 8010ExtracellularSequence analysis
Transmembranei81 – 10121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini102 – 12322CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini145 – 16420ExtracellularSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini186 – 20015CytoplasmicSequence analysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini222 – 2221ExtracellularSequence analysis
Transmembranei223 – 24321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini244 – 28946CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Mas-related G-protein coupled receptor member GPRO_0000069769Add
BLAST

Proteomic databases

PRIDEiQ7TN39.

Structurei

3D structure databases

ProteinModelPortaliQ7TN39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ7TN39.
KOiK08395.
PhylomeDBiQ7TN39.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF32. PTHR11334:SF32. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.

Sequencei

Sequence statusi: Complete.

Q7TN39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIFNIWGT FNRVLFFLSL TVSLAGLAGN TLLLWHLGLR IKKGPFNTYL
60 70 80 90 100
LHLAAADFLF LSCQVGFSIA KIASGYEDTL YFPVTFLWFA VGLWLLAAFI
110 120 130 140 150
VDCCLSYMFP SFCGPNCRPR YTSFVLCLVI WALTMLAVLL PANACGLLYN
160 170 180 190 200
RMSLLVCLKY HWVSVVWLGV LASTACGASM FLLVFGNCCS SQPPSKFCKL
210 220 230 240 250
AQCSGILLFF CRLPLVFYWC LRPVIKFLLP FFFPLATLLA CIDSSAKPLL
260 270 280
YYLKGRQLRK EPLQVALNRA LGEESQSSSG GISLPMSRV
Length:289
Mass (Da):32,212
Last modified:October 1, 2003 - v1
Checksum:i1D4C27EF394311E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518248 Genomic DNA. Translation: AAQ08320.1.
RefSeqiNP_982296.1. NM_203470.1.
UniGeneiRn.112764.

Genome annotation databases

GeneIDi309133.
KEGGirno:309133.
UCSCiRGD:738044. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518248 Genomic DNA. Translation: AAQ08320.1.
RefSeqiNP_982296.1. NM_203470.1.
UniGeneiRn.112764.

3D structure databases

ProteinModelPortaliQ7TN39.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ7TN39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309133.
KEGGirno:309133.
UCSCiRGD:738044. rat.

Organism-specific databases

CTDi386746.
RGDi738044. Mrgprg.

Phylogenomic databases

HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ7TN39.
KOiK08395.
PhylomeDBiQ7TN39.

Miscellaneous databases

NextBioi660209.
PROiQ7TN39.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF32. PTHR11334:SF32. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
ProtoNetiSearch...

Publicationsi

  1. "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."
    Zylka M.J., Dong X., Southwell A.L., Anderson D.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiMRGRG_RAT
AccessioniPrimary (citable) accession number: Q7TN39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.