Q7TN38 (MRGRH_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member H

Gene names

Name:	Mrgprh
Synonyms:	Mrgh

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Mas-related G-protein coupled receptor member H		PRO_0000069771
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Name=1; Potential
	Topological domain	57 – 71	15	Cytoplasmic Potential
	Transmembrane	72 – 92	21	Helical; Name=2; Potential
	Topological domain	93 – 102	10	Extracellular Potential
	Transmembrane	103 – 126	24	Helical; Name=3; Potential
	Topological domain	127 – 147	21	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=4; Potential
	Topological domain	169 – 188	20	Extracellular Potential
	Transmembrane	189 – 209	21	Helical; Name=5; Potential
	Topological domain	210 – 225	16	Cytoplasmic Potential
	Transmembrane	226 – 246	21	Helical; Name=6; Potential
	Topological domain	247	1	Extracellular Potential
	Transmembrane	248 – 271	24	Helical; Name=7; Potential
	Topological domain	272 – 320	49	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	23	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7TN38 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 763649B4D06D5D0A	FASTA	321	36,780
	10 20 30 40 50 60 MEPLATTLCP QECTQTTRNE TPNETTWSSE HVTKYTYISI SLVICSLGLV GNGLLIWFLI 70 80 90 100 110 120 FCIKRKPFTI YILHLAFADF MVLLCSSIIQ LVNTFHIYDS TLVSYAVLFM IFGYNTGLHL 130 140 150 160 170 180 LTAISVERCL SVLYPIWYHC RRPKHQSTVA CTLLWALSVL VSGLENFFCI LEVKPQFPEC 190 200 210 220 230 240 RYVYIFSCTL TFLVFVPLMV FSNLILFIQV CCNLKPRQPA KLYVIIMATV ILFLVFAMPM 250 260 270 280 290 300 KVLLIIGYYS NSTDASVWKS LPYLNMLSTI NCSINPIVYF VVGSLRRKRS RKSLKEALQK 310 320 VFEEKPVVAS RENEVQFSLP L

References

[1]

"Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family." Zylka M.J., Dong X., Southwell A.L., Anderson D.J. Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF518249 Genomic DNA. Translation: AAQ08321.1.
IPI	IPI00359193.
RefSeq	NP_001002281.1. NM_001002281.1.
UniGene	Rn.142013.
3D structure databases
ProteinModelPortal	Q7TN38.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000020070; ENSRNOP00000020070; ENSRNOG00000014965.
GeneID	404641.
KEGG	rno:404641.
Organism-specific databases
CTD	80978.
RGD	738049. Mrgprh.
Phylogenomic databases
eggNOG	NOG307320.
GeneTree	ENSGT00550000074531.
HOGENOM	HOG000015412.
HOVERGEN	HBG098384.
InParanoid	Q7TN38.
OMA	GLENFFC.
OrthoDB	EOG4SJ5F8.
Gene expression databases
Genevestigator	Q7TN38.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR026234. MRGPCRFAMILY. IPR026221. MRGPCRH. [Graphical view]
PANTHER	PTHR11334. PTHR11334. 1 hit. PTHR11334:SF5. PTHR11334:SF5. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR02108. MRGPCRFAMILY. PR02113. MRGPCRH.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	692756.

Entry information

Entry name

MRGRH_RAT

Accession

Primary (citable) accession number: Q7TN38

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program