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Q7TN31 (AGGF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angiogenic factor with G patch and FHA domains 1
Alternative name(s):
Angiogenic factor VG5Q
Short name=mVG5Q
Gene names
Name:Aggf1
Synonyms:Vg5q
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion By similarity.

Subunit structure

Interacts with the secreted angiogenic factor TNFSF12 By similarity.

Subcellular location

Cytoplasm By similarity. Secreted By similarity. Note: Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted By similarity.

Sequence similarities

Contains 1 FHA domain.

Contains 1 G-patch domain.

Sequence caution

The sequence AAH27286.1 differs from that shown. Reason: Erroneous initiation.

The sequence AK009533 differs from that shown. Reason: Frameshift at position 289.

The sequence AK017248 differs from that shown. Reason: Frameshift at positions 1 and 42.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Angiogenic factor with G patch and FHA domains 1
PRO_0000064496

Regions

Domain431 – 48454FHA
Domain616 – 66247G-patch
Coiled coil19 – 8567 Potential
Compositional bias6 – 1611Poly-Pro

Amino acid modifications

Modified residue6611N6-acetyllysine By similarity

Experimental info

Sequence conflict2471S → C in AK009533. Ref.2
Sequence conflict4481V → A in AAH27286. Ref.3
Sequence conflict5091L → M in AAH27286. Ref.3
Sequence conflict5781A → V in AAH27286. Ref.3
Sequence conflict6311R → Q in AAH27286. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q7TN31 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 1EEABAF35608F214

FASTA71179,445
        10         20         30         40         50         60 
MASEAPSPPS PSPPPPASPE PELAQLRRKV EKLERELRSC RRQVREVEKL LQHTERLYRN 

        70         80         90        100        110        120 
AESDNQELRT QVEELSKILH CGKNEDNPKS DVEVQTESQA PWAISDYYYQ TCYNDDSLPS 

       130        140        150        160        170        180 
KETELCVQQS QCAQASALDP QDESHIDSGS YAGADATEGV SHRQEDAVTS DSQESVSALA 

       190        200        210        220        230        240 
EGPALEGSSL AESLRAAAEA AVSQTGFTYD ESTGLYFDHS TGFYYDSENQ LYYDPSTGIY 

       250        260        270        280        290        300 
YYCDVESGRY QFHSRVDLQP YQTSSTKPNR ERRLKKRRKE PGFYTANEEK DLSSEDQKVC 

       310        320        330        340        350        360 
SVEYINCSED EHSGNVKKKA RTDTSHKSSP LQLTVAVSGD TVESPGDDNS ASSKDERIGE 

       370        380        390        400        410        420 
SESEPEEGEI TDSQSEKSYD GDSSSGDRET SEESDDEDEE RIWPPCIRVI VIRSPVLQMG 

       430        440        450        460        470        480 
SLFIITAVSP ATIGREKDME HTVRIPEVAV SKFHAEVYFD HDLQSYVLVD QGSQNGTIVN 

       490        500        510        520        530        540 
GKQILQPKTK CDPYVLEHGD EVKIGETVLS FHIHPGSETC DGCEPGQVRA HLRLDRKDEP 

       550        560        570        580        590        600 
LVGPALSKEE KELERRKALK KIRVKYGLQN TDYEAEKALK NPKYKDRAGK RREQVGSEGT 

       610        620        630        640        650        660 
FQRDDAPASV HSEITDSNKG RKMLEKMGWK RGEGLGKDGG GMKTPIQLQL RRTHAGLGTG 

       670        680        690        700        710 
KLSSIDDVHL IQNKSKKHWD KARERFAETF TENKPRKETP GAVPWVTGTA E

« Hide

References

« Hide 'large scale' references
[1]"Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome."
Tian X.-L., Kadaba R., You S.-A., Liu M., Timur A.A., Yang L., Chen Q., Szafranski P., Rao S., Wu L., Housman D.E., DiCorleto P.E., Driscoll D.J., Borrow J., Wang Q.
Nature 427:640-645(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head, Small intestine and Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Embryonic brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY500995 mRNA. Translation: AAR97616.1.
AK008168 mRNA. Translation: BAB25506.3.
AK008399 mRNA. Translation: BAB25648.3.
AK009533 mRNA. No translation available.
AK017248 mRNA. No translation available.
BC027286 mRNA. Translation: AAH27286.1. Different initiation.
BC052410 mRNA. Translation: AAH52410.1.
IPIIPI00187239.
RefSeqNP_079906.2. NM_025630.2.
UniGeneMm.36785.

3D structure databases

ProteinModelPortalQ7TN31.
SMRQ7TN31. Positions 432-515.
ModBaseSearch...

PTM databases

PhosphoSiteQ7TN31.

Proteomic databases

PRIDEQ7TN31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022189; ENSMUSP00000022189; ENSMUSG00000021681.
GeneID66549.
KEGGmmu:66549.
UCSCuc007rmi.1. mouse.

Organism-specific databases

CTD55109.
MGIMGI:1913799. Aggf1.

Phylogenomic databases

eggNOGNOG270400.
GeneTreeENSGT00510000046476.
HOGENOMHOG000033843.
HOVERGENHBG050465.
InParanoidQ7TN31.
OMANKNKKNW.
OrthoDBEOG4S1T6Q.

Gene expression databases

BgeeQ7TN31.
CleanExMM_AGGF1.
GenevestigatorQ7TN31.
GermOnlineENSMUSG00000021681. Mus musculus.

Family and domain databases

Gene3D2.60.200.20. 1 hit.
InterProIPR000253. FHA_dom.
IPR000467. G_patch_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamPF00498. FHA. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTSM00240. FHA. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMSSF49879. SMAD_FHA. 1 hit.
PROSITEPS50006. FHA_DOMAIN. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAGGF1. mouse.
NextBio321992.
SOURCESearch...

Entry information

Entry nameAGGF1_MOUSE
AccessionPrimary (citable) accession number: Q7TN31
Secondary accession number(s): Q8R2S6 expand/collapse secondary AC list , Q9CQR9, Q9CU87, Q9D768
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents