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Protein

Angiogenic factor with G patch and FHA domains 1

Gene

Aggf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion (By similarity).By similarity

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell adhesion Source: UniProtKB
  3. cell differentiation Source: UniProtKB-KW
  4. positive regulation of angiogenesis Source: UniProtKB
  5. positive regulation of endothelial cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiogenic factor with G patch and FHA domains 1
Alternative name(s):
Angiogenic factor VG5Q
Short name:
mVG5Q
Gene namesi
Name:Aggf1
Synonyms:Vg5q
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1913799. Aggf1.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity
Note: Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 711710Angiogenic factor with G patch and FHA domains 1PRO_0000064496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei661 – 6611N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7TN31.
PRIDEiQ7TN31.

PTM databases

PhosphoSiteiQ7TN31.

Expressioni

Gene expression databases

BgeeiQ7TN31.
CleanExiMM_AGGF1.
GenevestigatoriQ7TN31.

Interactioni

Subunit structurei

Interacts with the secreted angiogenic factor TNFSF12.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7TN31.
SMRiQ7TN31. Positions 432-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini431 – 48454FHAPROSITE-ProRule annotationAdd
BLAST
Domaini616 – 66247G-patchPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili19 – 8567Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 1611Poly-ProAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270400.
GeneTreeiENSGT00730000111121.
HOGENOMiHOG000033843.
HOVERGENiHBG050465.
InParanoidiQ7TN31.
OMAiNRILQPK.
OrthoDBiEOG7C2R1J.
PhylomeDBiQ7TN31.
TreeFamiTF315789.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR000467. G_patch_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TN31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASEAPSPPS PSPPPPASPE PELAQLRRKV EKLERELRSC RRQVREVEKL
60 70 80 90 100
LQHTERLYRN AESDNQELRT QVEELSKILH CGKNEDNPKS DVEVQTESQA
110 120 130 140 150
PWAISDYYYQ TCYNDDSLPS KETELCVQQS QCAQASALDP QDESHIDSGS
160 170 180 190 200
YAGADATEGV SHRQEDAVTS DSQESVSALA EGPALEGSSL AESLRAAAEA
210 220 230 240 250
AVSQTGFTYD ESTGLYFDHS TGFYYDSENQ LYYDPSTGIY YYCDVESGRY
260 270 280 290 300
QFHSRVDLQP YQTSSTKPNR ERRLKKRRKE PGFYTANEEK DLSSEDQKVC
310 320 330 340 350
SVEYINCSED EHSGNVKKKA RTDTSHKSSP LQLTVAVSGD TVESPGDDNS
360 370 380 390 400
ASSKDERIGE SESEPEEGEI TDSQSEKSYD GDSSSGDRET SEESDDEDEE
410 420 430 440 450
RIWPPCIRVI VIRSPVLQMG SLFIITAVSP ATIGREKDME HTVRIPEVAV
460 470 480 490 500
SKFHAEVYFD HDLQSYVLVD QGSQNGTIVN GKQILQPKTK CDPYVLEHGD
510 520 530 540 550
EVKIGETVLS FHIHPGSETC DGCEPGQVRA HLRLDRKDEP LVGPALSKEE
560 570 580 590 600
KELERRKALK KIRVKYGLQN TDYEAEKALK NPKYKDRAGK RREQVGSEGT
610 620 630 640 650
FQRDDAPASV HSEITDSNKG RKMLEKMGWK RGEGLGKDGG GMKTPIQLQL
660 670 680 690 700
RRTHAGLGTG KLSSIDDVHL IQNKSKKHWD KARERFAETF TENKPRKETP
710
GAVPWVTGTA E
Length:711
Mass (Da):79,445
Last modified:October 1, 2003 - v1
Checksum:i1EEABAF35608F214
GO

Sequence cautioni

The sequence AAH27286.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AK009533 differs from that shown. Reason: Frameshift at position 289. Curated
The sequence AK017248 differs from that shown. Reason: Frameshift at positions 2 and 42. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471S → C in AK009533. (PubMed:16141072)Curated
Sequence conflicti448 – 4481V → A in AAH27286. (PubMed:15489334)Curated
Sequence conflicti509 – 5091L → M in AAH27286. (PubMed:15489334)Curated
Sequence conflicti578 – 5781A → V in AAH27286. (PubMed:15489334)Curated
Sequence conflicti631 – 6311R → Q in AAH27286. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY500995 mRNA. Translation: AAR97616.1.
AK008168 mRNA. Translation: BAB25506.3.
AK008399 mRNA. Translation: BAB25648.3.
AK009533 mRNA. No translation available.
AK017248 mRNA. No translation available.
BC027286 mRNA. Translation: AAH27286.1. Different initiation.
BC052410 mRNA. Translation: AAH52410.1.
CCDSiCCDS26697.1.
RefSeqiNP_079906.2. NM_025630.3.
UniGeneiMm.36785.

Genome annotation databases

EnsembliENSMUST00000022189; ENSMUSP00000022189; ENSMUSG00000021681.
GeneIDi66549.
KEGGimmu:66549.
UCSCiuc007rmi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY500995 mRNA. Translation: AAR97616.1.
AK008168 mRNA. Translation: BAB25506.3.
AK008399 mRNA. Translation: BAB25648.3.
AK009533 mRNA. No translation available.
AK017248 mRNA. No translation available.
BC027286 mRNA. Translation: AAH27286.1. Different initiation.
BC052410 mRNA. Translation: AAH52410.1.
CCDSiCCDS26697.1.
RefSeqiNP_079906.2. NM_025630.3.
UniGeneiMm.36785.

3D structure databases

ProteinModelPortaliQ7TN31.
SMRiQ7TN31. Positions 432-515.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ7TN31.

Proteomic databases

MaxQBiQ7TN31.
PRIDEiQ7TN31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022189; ENSMUSP00000022189; ENSMUSG00000021681.
GeneIDi66549.
KEGGimmu:66549.
UCSCiuc007rmi.1. mouse.

Organism-specific databases

CTDi55109.
MGIiMGI:1913799. Aggf1.

Phylogenomic databases

eggNOGiNOG270400.
GeneTreeiENSGT00730000111121.
HOGENOMiHOG000033843.
HOVERGENiHBG050465.
InParanoidiQ7TN31.
OMAiNRILQPK.
OrthoDBiEOG7C2R1J.
PhylomeDBiQ7TN31.
TreeFamiTF315789.

Miscellaneous databases

ChiTaRSiAggf1. mouse.
NextBioi321992.
PROiQ7TN31.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TN31.
CleanExiMM_AGGF1.
GenevestigatoriQ7TN31.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR000467. G_patch_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome."
    Tian X.-L., Kadaba R., You S.-A., Liu M., Timur A.A., Yang L., Chen Q., Szafranski P., Rao S., Wu L., Housman D.E., DiCorleto P.E., Driscoll D.J., Borrow J., Wang Q.
    Nature 427:640-645(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Small intestine and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryonic brain and Mammary tumor.

Entry informationi

Entry nameiAGGF1_MOUSE
AccessioniPrimary (citable) accession number: Q7TN31
Secondary accession number(s): Q8R2S6
, Q9CQR9, Q9CU87, Q9D768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.