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Q7TN31

- AGGF1_MOUSE

UniProt

Q7TN31 - AGGF1_MOUSE

Protein

Angiogenic factor with G patch and FHA domains 1

Gene

Aggf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion By similarity.By similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell adhesion Source: UniProtKB
    3. cell differentiation Source: UniProtKB-KW
    4. positive regulation of angiogenesis Source: UniProtKB
    5. positive regulation of endothelial cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiogenic factor with G patch and FHA domains 1
    Alternative name(s):
    Angiogenic factor VG5Q
    Short name:
    mVG5Q
    Gene namesi
    Name:Aggf1
    Synonyms:Vg5q
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1913799. Aggf1.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity
    Note: Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 711710Angiogenic factor with G patch and FHA domains 1PRO_0000064496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei661 – 6611N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ7TN31.

    PTM databases

    PhosphoSiteiQ7TN31.

    Expressioni

    Gene expression databases

    BgeeiQ7TN31.
    CleanExiMM_AGGF1.
    GenevestigatoriQ7TN31.

    Interactioni

    Subunit structurei

    Interacts with the secreted angiogenic factor TNFSF12.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TN31.
    SMRiQ7TN31. Positions 432-515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini431 – 48454FHAPROSITE-ProRule annotationAdd
    BLAST
    Domaini616 – 66247G-patchPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili19 – 8567Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 1611Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FHA domain.PROSITE-ProRule annotation
    Contains 1 G-patch domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270400.
    GeneTreeiENSGT00730000111121.
    HOGENOMiHOG000033843.
    HOVERGENiHBG050465.
    InParanoidiQ7TN31.
    OMAiQNTEYED.
    OrthoDBiEOG7C2R1J.
    PhylomeDBiQ7TN31.
    TreeFamiTF315789.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    InterProiIPR000253. FHA_dom.
    IPR000467. G_patch_dom.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PfamiPF00498. FHA. 1 hit.
    PF01585. G-patch. 1 hit.
    [Graphical view]
    SMARTiSM00240. FHA. 1 hit.
    SM00443. G_patch. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS50006. FHA_DOMAIN. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7TN31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASEAPSPPS PSPPPPASPE PELAQLRRKV EKLERELRSC RRQVREVEKL    50
    LQHTERLYRN AESDNQELRT QVEELSKILH CGKNEDNPKS DVEVQTESQA 100
    PWAISDYYYQ TCYNDDSLPS KETELCVQQS QCAQASALDP QDESHIDSGS 150
    YAGADATEGV SHRQEDAVTS DSQESVSALA EGPALEGSSL AESLRAAAEA 200
    AVSQTGFTYD ESTGLYFDHS TGFYYDSENQ LYYDPSTGIY YYCDVESGRY 250
    QFHSRVDLQP YQTSSTKPNR ERRLKKRRKE PGFYTANEEK DLSSEDQKVC 300
    SVEYINCSED EHSGNVKKKA RTDTSHKSSP LQLTVAVSGD TVESPGDDNS 350
    ASSKDERIGE SESEPEEGEI TDSQSEKSYD GDSSSGDRET SEESDDEDEE 400
    RIWPPCIRVI VIRSPVLQMG SLFIITAVSP ATIGREKDME HTVRIPEVAV 450
    SKFHAEVYFD HDLQSYVLVD QGSQNGTIVN GKQILQPKTK CDPYVLEHGD 500
    EVKIGETVLS FHIHPGSETC DGCEPGQVRA HLRLDRKDEP LVGPALSKEE 550
    KELERRKALK KIRVKYGLQN TDYEAEKALK NPKYKDRAGK RREQVGSEGT 600
    FQRDDAPASV HSEITDSNKG RKMLEKMGWK RGEGLGKDGG GMKTPIQLQL 650
    RRTHAGLGTG KLSSIDDVHL IQNKSKKHWD KARERFAETF TENKPRKETP 700
    GAVPWVTGTA E 711
    Length:711
    Mass (Da):79,445
    Last modified:October 1, 2003 - v1
    Checksum:i1EEABAF35608F214
    GO

    Sequence cautioni

    The sequence AK009533 differs from that shown. Reason: Frameshift at position 289.
    The sequence AK017248 differs from that shown. Reason: Frameshift at positions 2 and 42.
    The sequence AAH27286.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471S → C in AK009533. (PubMed:16141072)Curated
    Sequence conflicti448 – 4481V → A in AAH27286. (PubMed:15489334)Curated
    Sequence conflicti509 – 5091L → M in AAH27286. (PubMed:15489334)Curated
    Sequence conflicti578 – 5781A → V in AAH27286. (PubMed:15489334)Curated
    Sequence conflicti631 – 6311R → Q in AAH27286. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY500995 mRNA. Translation: AAR97616.1.
    AK008168 mRNA. Translation: BAB25506.3.
    AK008399 mRNA. Translation: BAB25648.3.
    AK009533 mRNA. No translation available.
    AK017248 mRNA. No translation available.
    BC027286 mRNA. Translation: AAH27286.1. Different initiation.
    BC052410 mRNA. Translation: AAH52410.1.
    CCDSiCCDS26697.1.
    RefSeqiNP_079906.2. NM_025630.3.
    UniGeneiMm.36785.

    Genome annotation databases

    EnsembliENSMUST00000022189; ENSMUSP00000022189; ENSMUSG00000021681.
    GeneIDi66549.
    KEGGimmu:66549.
    UCSCiuc007rmi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY500995 mRNA. Translation: AAR97616.1 .
    AK008168 mRNA. Translation: BAB25506.3 .
    AK008399 mRNA. Translation: BAB25648.3 .
    AK009533 mRNA. No translation available.
    AK017248 mRNA. No translation available.
    BC027286 mRNA. Translation: AAH27286.1 . Different initiation.
    BC052410 mRNA. Translation: AAH52410.1 .
    CCDSi CCDS26697.1.
    RefSeqi NP_079906.2. NM_025630.3.
    UniGenei Mm.36785.

    3D structure databases

    ProteinModelPortali Q7TN31.
    SMRi Q7TN31. Positions 432-515.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q7TN31.

    Proteomic databases

    PRIDEi Q7TN31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022189 ; ENSMUSP00000022189 ; ENSMUSG00000021681 .
    GeneIDi 66549.
    KEGGi mmu:66549.
    UCSCi uc007rmi.1. mouse.

    Organism-specific databases

    CTDi 55109.
    MGIi MGI:1913799. Aggf1.

    Phylogenomic databases

    eggNOGi NOG270400.
    GeneTreei ENSGT00730000111121.
    HOGENOMi HOG000033843.
    HOVERGENi HBG050465.
    InParanoidi Q7TN31.
    OMAi QNTEYED.
    OrthoDBi EOG7C2R1J.
    PhylomeDBi Q7TN31.
    TreeFami TF315789.

    Miscellaneous databases

    ChiTaRSi AGGF1. mouse.
    NextBioi 321992.
    PROi Q7TN31.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TN31.
    CleanExi MM_AGGF1.
    Genevestigatori Q7TN31.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    InterProi IPR000253. FHA_dom.
    IPR000467. G_patch_dom.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    Pfami PF00498. FHA. 1 hit.
    PF01585. G-patch. 1 hit.
    [Graphical view ]
    SMARTi SM00240. FHA. 1 hit.
    SM00443. G_patch. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS50006. FHA_DOMAIN. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome."
      Tian X.-L., Kadaba R., You S.-A., Liu M., Timur A.A., Yang L., Chen Q., Szafranski P., Rao S., Wu L., Housman D.E., DiCorleto P.E., Driscoll D.J., Borrow J., Wang Q.
      Nature 427:640-645(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head, Small intestine and Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Embryonic brain and Mammary tumor.

    Entry informationi

    Entry nameiAGGF1_MOUSE
    AccessioniPrimary (citable) accession number: Q7TN31
    Secondary accession number(s): Q8R2S6
    , Q9CQR9, Q9CU87, Q9D768
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3