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Protein

Thioredoxin domain-containing protein 16

Gene

Txndc16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 16
Gene namesi
Name:Txndc16Imported
Synonyms:Kiaa1344
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917811 Txndc16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000025779025 – 820Thioredoxin domain-containing protein 16Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi450 ↔ 457By similarity
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TN22
PeptideAtlasiQ7TN22
PRIDEiQ7TN22

PTM databases

PhosphoSitePlusiQ7TN22

Expressioni

Gene expression databases

BgeeiENSMUSG00000021830
CleanExiMM_TXNDC16
ExpressionAtlasiQ7TN22 baseline and differential
GenevisibleiQ7TN22 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022377

Structurei

3D structure databases

ProteinModelPortaliQ7TN22
SMRiQ7TN22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 496ThioredoxinAdd BLAST103

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi817 – 820Mediates endoplasmic reticulum retentionBy similarity4

Domaini

Contains a masked and non-functional KDEL endoplasmic reticulum retrieval motif.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00390000006080
HOGENOMiHOG000090200
HOVERGENiHBG081835
InParanoidiQ7TN22
OMAiRINCADW
OrthoDBiEOG091G0HO3
TreeFamiTF328825

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TN22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSSGFSVFR AGVALVLMCS FYKSTEDSLP ELTPQQYFST LQPGKASLVY
60 70 80 90 100
FCQVGSLSNS VFLEELKEAV KPLQDYGISV AKVTCVEEEA SRYCGEEEGL
110 120 130 140 150
MKAYLFRGNI LLREFPTDIL FDVNAIIAHV LFALLFNEVK YITTLEDLHS
160 170 180 190 200
IENSLKGKSN MIFSYVEAIG TPEHRAVMEA AFVYGTSYQF ALTTEIALLE
210 220 230 240 250
NIGSESIEHA HLYFFHCKLV LDLTEHCRRT LMEQPLTTLN IHVFVKTMNA
260 270 280 290 300
PLLMEVAEDP QQVSTVHLQL GLPLVFIISQ RATQEADRRT AEWVAWHLLG
310 320 330 340 350
KAGVLLLLRD SMDVNIPQHA NVAFRRAEKD VPVEFLVLND VELIISHVKN
360 370 380 390 400
NMHIEEIQED EGEDMEGPDL AVEDDEVAGT VYRDRKKPLP LELSVELTEE
410 420 430 440 450
TFNTTVMTSD SIVLFYATWH AVSMAFLQSY IDVAIKLKGR STILLTRINC
460 470 480 490 500
ADWSDICTKQ NVTAFPVVKL YKEGESPVSY AGMLATKDLL KFIQLNKISC
510 520 530 540 550
PVNIASIQEA EKYLRGELYK DLPSSASVSV LGLFSPAMAS AKELFREAGK
560 570 580 590 600
QLRGSVITGI YSEDDVWILS NKYATTLPAL LLARPKEGRI ESVPLDTTLV
610 620 630 640 650
QDMAQILANA LLEAFPEITV ENLPTYLRFQ RPLLLLFSGG SINPQYRNTI
660 670 680 690 700
LALVRQKQLD SFTPCWLNLK NTPVGRGILK AYFGRLPPLP QLLLVNLHSG
710 720 730 740 750
GQVYAFPSSQ SVTEQSLVLW LKHLQAGLEN PITVLSAQEW KPPLPAFDFL
760 770 780 790 800
NMMDAPTSQA PTKKVLECQK EAEVQESAEL QPGDRSTARR EPVEMLRIKR
810 820
WNTANWPKDT QEPFHHDKEL
Length:820
Mass (Da):92,105
Last modified:October 1, 2003 - v1
Checksum:i6006949E004D2BC0
GO
Isoform 2 (identifier: Q7TN22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     733-734: TV → I

Note: No experimental confirmation available.
Show »
Length:819
Mass (Da):92,018
Checksum:iC20FED0FE10A2456
GO

Sequence cautioni

The sequence BAD32431 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021364733 – 734TV → I in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173153 mRNA Translation: BAD32431.1 Different initiation.
AK017582 mRNA Translation: BAB30819.1
AK046466 mRNA Translation: BAC32743.1
BC027108 mRNA Translation: AAH27108.1
BC052488 mRNA Translation: AAH52488.1
CCDSiCCDS26973.1 [Q7TN22-2]
CCDS79300.1 [Q7TN22-1]
RefSeqiNP_001297463.1, NM_001310534.1 [Q7TN22-1]
NP_766185.1, NM_172597.3 [Q7TN22-2]
XP_006519583.1, XM_006519520.3 [Q7TN22-1]
XP_011243482.1, XM_011245180.2 [Q7TN22-1]
XP_017171675.1, XM_017316186.1 [Q7TN22-1]
UniGeneiMm.28129

Genome annotation databases

EnsembliENSMUST00000022377; ENSMUSP00000022377; ENSMUSG00000021830 [Q7TN22-2]
ENSMUST00000123879; ENSMUSP00000123023; ENSMUSG00000021830 [Q7TN22-1]
ENSMUST00000139526; ENSMUSP00000120287; ENSMUSG00000021830 [Q7TN22-1]
GeneIDi70561
KEGGimmu:70561
UCSCiuc007tge.1 mouse [Q7TN22-2]
uc007tgf.1 mouse [Q7TN22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTXD16_MOUSE
AccessioniPrimary (citable) accession number: Q7TN22
Secondary accession number(s): Q69ZL5
, Q8BL40, Q8R2W8, Q9CS82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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