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Protein

Thioredoxin domain-containing protein 16

Gene

Txndc16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 16
Gene namesi
Name:Txndc16
Synonyms:Kiaa1344
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917811. Txndc16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 820796Thioredoxin domain-containing protein 16PRO_0000257790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7TN22.
PaxDbiQ7TN22.
PeptideAtlasiQ7TN22.
PRIDEiQ7TN22.

PTM databases

PhosphoSiteiQ7TN22.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021830.
CleanExiMM_TXNDC16.
ExpressionAtlasiQ7TN22. baseline and differential.
GenevisibleiQ7TN22. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022377.

Structurei

3D structure databases

ProteinModelPortaliQ7TN22.
SMRiQ7TN22. Positions 389-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 496103ThioredoxinAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00390000006080.
HOGENOMiHOG000090200.
HOVERGENiHBG081835.
InParanoidiQ7TN22.
OMAiRINCADW.
OrthoDBiEOG091G0HO3.
TreeFamiTF328825.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TN22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSSGFSVFR AGVALVLMCS FYKSTEDSLP ELTPQQYFST LQPGKASLVY
60 70 80 90 100
FCQVGSLSNS VFLEELKEAV KPLQDYGISV AKVTCVEEEA SRYCGEEEGL
110 120 130 140 150
MKAYLFRGNI LLREFPTDIL FDVNAIIAHV LFALLFNEVK YITTLEDLHS
160 170 180 190 200
IENSLKGKSN MIFSYVEAIG TPEHRAVMEA AFVYGTSYQF ALTTEIALLE
210 220 230 240 250
NIGSESIEHA HLYFFHCKLV LDLTEHCRRT LMEQPLTTLN IHVFVKTMNA
260 270 280 290 300
PLLMEVAEDP QQVSTVHLQL GLPLVFIISQ RATQEADRRT AEWVAWHLLG
310 320 330 340 350
KAGVLLLLRD SMDVNIPQHA NVAFRRAEKD VPVEFLVLND VELIISHVKN
360 370 380 390 400
NMHIEEIQED EGEDMEGPDL AVEDDEVAGT VYRDRKKPLP LELSVELTEE
410 420 430 440 450
TFNTTVMTSD SIVLFYATWH AVSMAFLQSY IDVAIKLKGR STILLTRINC
460 470 480 490 500
ADWSDICTKQ NVTAFPVVKL YKEGESPVSY AGMLATKDLL KFIQLNKISC
510 520 530 540 550
PVNIASIQEA EKYLRGELYK DLPSSASVSV LGLFSPAMAS AKELFREAGK
560 570 580 590 600
QLRGSVITGI YSEDDVWILS NKYATTLPAL LLARPKEGRI ESVPLDTTLV
610 620 630 640 650
QDMAQILANA LLEAFPEITV ENLPTYLRFQ RPLLLLFSGG SINPQYRNTI
660 670 680 690 700
LALVRQKQLD SFTPCWLNLK NTPVGRGILK AYFGRLPPLP QLLLVNLHSG
710 720 730 740 750
GQVYAFPSSQ SVTEQSLVLW LKHLQAGLEN PITVLSAQEW KPPLPAFDFL
760 770 780 790 800
NMMDAPTSQA PTKKVLECQK EAEVQESAEL QPGDRSTARR EPVEMLRIKR
810 820
WNTANWPKDT QEPFHHDKEL
Length:820
Mass (Da):92,105
Last modified:October 1, 2003 - v1
Checksum:i6006949E004D2BC0
GO
Isoform 2 (identifier: Q7TN22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     733-734: TV → I

Note: No experimental confirmation available.
Show »
Length:819
Mass (Da):92,018
Checksum:iC20FED0FE10A2456
GO

Sequence cautioni

The sequence BAD32431 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei733 – 7342TV → I in isoform 2. 1 PublicationVSP_021364

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173153 mRNA. Translation: BAD32431.1. Different initiation.
AK017582 mRNA. Translation: BAB30819.1.
AK046466 mRNA. Translation: BAC32743.1.
BC027108 mRNA. Translation: AAH27108.1.
BC052488 mRNA. Translation: AAH52488.1.
CCDSiCCDS26973.1. [Q7TN22-2]
CCDS79300.1. [Q7TN22-1]
RefSeqiNP_001297463.1. NM_001310534.1. [Q7TN22-1]
NP_766185.1. NM_172597.3. [Q7TN22-2]
XP_006519583.1. XM_006519520.2. [Q7TN22-1]
XP_011243482.1. XM_011245180.1. [Q7TN22-1]
XP_011243483.1. XM_011245181.1. [Q7TN22-1]
UniGeneiMm.28129.

Genome annotation databases

EnsembliENSMUST00000022377; ENSMUSP00000022377; ENSMUSG00000021830. [Q7TN22-2]
ENSMUST00000123879; ENSMUSP00000123023; ENSMUSG00000021830. [Q7TN22-1]
ENSMUST00000139526; ENSMUSP00000120287; ENSMUSG00000021830. [Q7TN22-1]
GeneIDi70561.
KEGGimmu:70561.
UCSCiuc007tge.1. mouse. [Q7TN22-2]
uc007tgf.1. mouse. [Q7TN22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173153 mRNA. Translation: BAD32431.1. Different initiation.
AK017582 mRNA. Translation: BAB30819.1.
AK046466 mRNA. Translation: BAC32743.1.
BC027108 mRNA. Translation: AAH27108.1.
BC052488 mRNA. Translation: AAH52488.1.
CCDSiCCDS26973.1. [Q7TN22-2]
CCDS79300.1. [Q7TN22-1]
RefSeqiNP_001297463.1. NM_001310534.1. [Q7TN22-1]
NP_766185.1. NM_172597.3. [Q7TN22-2]
XP_006519583.1. XM_006519520.2. [Q7TN22-1]
XP_011243482.1. XM_011245180.1. [Q7TN22-1]
XP_011243483.1. XM_011245181.1. [Q7TN22-1]
UniGeneiMm.28129.

3D structure databases

ProteinModelPortaliQ7TN22.
SMRiQ7TN22. Positions 389-589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022377.

PTM databases

PhosphoSiteiQ7TN22.

Proteomic databases

MaxQBiQ7TN22.
PaxDbiQ7TN22.
PeptideAtlasiQ7TN22.
PRIDEiQ7TN22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022377; ENSMUSP00000022377; ENSMUSG00000021830. [Q7TN22-2]
ENSMUST00000123879; ENSMUSP00000123023; ENSMUSG00000021830. [Q7TN22-1]
ENSMUST00000139526; ENSMUSP00000120287; ENSMUSG00000021830. [Q7TN22-1]
GeneIDi70561.
KEGGimmu:70561.
UCSCiuc007tge.1. mouse. [Q7TN22-2]
uc007tgf.1. mouse. [Q7TN22-1]

Organism-specific databases

CTDi57544.
MGIiMGI:1917811. Txndc16.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00390000006080.
HOGENOMiHOG000090200.
HOVERGENiHBG081835.
InParanoidiQ7TN22.
OMAiRINCADW.
OrthoDBiEOG091G0HO3.
TreeFamiTF328825.

Miscellaneous databases

ChiTaRSiTxndc16. mouse.
PROiQ7TN22.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021830.
CleanExiMM_TXNDC16.
ExpressionAtlasiQ7TN22. baseline and differential.
GenevisibleiQ7TN22. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTXD16_MOUSE
AccessioniPrimary (citable) accession number: Q7TN22
Secondary accession number(s): Q69ZL5
, Q8BL40, Q8R2W8, Q9CS82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.