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Q7TN16

- HHIP_MOUSE

UniProt

Q7TN16 - HHIP_MOUSE

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Protein

Hedgehog-interacting protein

Gene
Hhip, Hip
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi383 – 3831Zinc; shared with SHH By similarity

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: InterPro
  2. protein binding Source: MGI
  3. quinone binding Source: InterPro
  4. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. dorsal/ventral pattern formation Source: MGI
  3. epithelial tube branching involved in lung morphogenesis Source: MGI
  4. negative regulation of angiogenesis Source: BHF-UCL
  5. negative regulation of signal transduction Source: UniProtKB
  6. negative regulation of smoothened signaling pathway Source: BHF-UCL
  7. neuroblast proliferation Source: MGI
  8. organ morphogenesis Source: MGI
  9. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  10. signal transduction Source: MGI
  11. skeletal system morphogenesis Source: BHF-UCL
  12. smoothened signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hedgehog-interacting protein
Short name:
HHIP
Short name:
HIP
Gene namesi
Name:Hhip
Synonyms:Hip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1341847. Hhip.

Subcellular locationi

Cell membrane; Peripheral membrane protein. Secreted
Note: The last 22 C-terminal amino acids may participate in cell membrane attachment.1 Publication

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular region Source: UniProtKB-SubCell
  3. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 700683Hedgehog-interacting proteinPRO_0000007624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi216 ↔ 536 By similarity
Disulfide bondi218 ↔ 543 By similarity
Disulfide bondi402 ↔ 624 By similarity
Glycosylationi416 – 4161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi435 ↔ 452 By similarity
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi500 ↔ 594 By similarity
Disulfide bondi612 ↔ 623 By similarity
Disulfide bondi625 ↔ 634 By similarity
Disulfide bondi639 ↔ 649 By similarity
Disulfide bondi643 ↔ 655 By similarity
Disulfide bondi657 ↔ 666 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7TN16.

PTM databases

PhosphoSiteiQ7TN16.

Expressioni

Tissue specificityi

In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the surerior colliculus.1 Publication

Developmental stagei

First detected at 8.75 dpc, in the ventral midline of the neural tube and in the ventral medial somites. At 10.5 dpc, expression in the notochord is maintained in the caudal region. Expression is lost in the floor plate, but is retained in the ventral half of the neural tube and in the sclerotome of the adjacent somites. In the midbrain, expression confined to two lateral stripes adjacent to the floor plate. Also expressed in the gut mesenchyme along the length of the gastro-intestinal tract and in the mesenchyme of the posterior half of the limb. Expressed in the underlying mesenchyme of the epithelium of a number of tissues including lung, gut and whisker. Also expressed in the perichondrium and in the androgen-producing interstitial somatic cells of the developing testis.1 Publication

Gene expression databases

BgeeiQ7TN16.
CleanExiMM_HHIP.
GenevestigatoriQ7TN16.

Interactioni

Subunit structurei

Interacts with all three hedgehog family members, SHH, IHH and DHH.1 Publication

Protein-protein interaction databases

BioGridi200300. 1 interaction.
MINTiMINT-4997541.

Structurei

3D structure databases

ProteinModelPortaliQ7TN16.
SMRiQ7TN16. Positions 214-668.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini607 – 63428EGF-like 1Add
BLAST
Domaini635 – 66733EGF-like 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni376 – 38813Interaction with SHH zinc binding site By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 5420Arg-richAdd
BLAST

Domaini

A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding By similarity.

Sequence similaritiesi

Belongs to the HHIP family.
Contains 2 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiCOG2133.
GeneTreeiENSGT00530000063250.
HOGENOMiHOG000008644.
HOVERGENiHBG051901.
InParanoidiQ7TN16.
KOiK06231.
OMAiFGDRNGN.
OrthoDBiEOG7CZK54.
PhylomeDBiQ7TN16.
TreeFamiTF329059.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TN16-1 [UniParc]FASTAAdd to Basket

« Hide

MLKMLSFKLL LLAVALGFFE GDAKFGERNE GSGARRRRCL NGNPPKRLKR    50
RDRRVMSQLE LLSGGEILCG GFYPRVSCCL QSDSPGLGRL ENKIFSATNN 100
SECSRLLEEI QCAPCSPHSQ SLFYTPERDV LDGDLALPLL CKDYCKEFFY 150
TCRGHIPGLL QTTADEFCFY YARKDAGLCF PDFPRKQVRG PASNYLGQME 200
DYEKVGGISR KHKHNCLCVQ EVMSGLRQPV SAVHSGDGSH RLFILEKEGY 250
VKILTPEGEL FKEPYLDIHK LVQSGIKGGD ERGLLSLAFH PNYKKNGKLY 300
VSYTTNQERW AIGPHDHILR VVEYTVSRKN PHQVDVRTAR VFLEVAELHR 350
KHLGGQLLFG PDGFLYIILG DGMITLDDME EMDGLSDFTG SVLRLDVDTD 400
MCNVPYSIPR SNPHFNSTNQ PPEVFAHGLH DPGRCAVDRH PTDININLTI 450
LCSDSNGKNR SSARILQIIK GRDYESEPSL LEFKPFSNGP LVGGFVYRGC 500
QSERLYGSYV FGDRNGNFLT LQQSPVTKQW QEKPLCLGAS SSCRGYFSGH 550
ILGFGEDELG EVYILSSSKS MTQTHNGKLY KIVDPKRPLM PEECRVTVQP 600
AQPLTSDCSR LCRNGYYTPT GKCCCSPGWE GDFCRIAKCE PACRHGGVCV 650
RPNKCLCKKG YLGPQCEQVD RNVRRVTRAG ILDQIIDMTS YLLDLTSYIV 700
Length:700
Mass (Da):78,513
Last modified:March 29, 2005 - v2
Checksum:i91007C5AF6070B80
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291N → S in AAD31172. 1 Publication
Sequence conflicti473 – 4731D → G in AAH53012. 1 Publication
Sequence conflicti607 – 6071D → V in BAC27575. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116865 mRNA. Translation: AAD31172.1.
AK031841 mRNA. Translation: BAC27575.1.
BC053012 mRNA. Translation: AAH53012.1.
CCDSiCCDS22440.1.
RefSeqiNP_064655.4. NM_020259.4.
UniGeneiMm.254493.

Genome annotation databases

EnsembliENSMUST00000079038; ENSMUSP00000078047; ENSMUSG00000064325.
GeneIDi15245.
KEGGimmu:15245.
UCSCiuc009mix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116865 mRNA. Translation: AAD31172.1 .
AK031841 mRNA. Translation: BAC27575.1 .
BC053012 mRNA. Translation: AAH53012.1 .
CCDSi CCDS22440.1.
RefSeqi NP_064655.4. NM_020259.4.
UniGenei Mm.254493.

3D structure databases

ProteinModelPortali Q7TN16.
SMRi Q7TN16. Positions 214-668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200300. 1 interaction.
MINTi MINT-4997541.

PTM databases

PhosphoSitei Q7TN16.

Proteomic databases

PRIDEi Q7TN16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079038 ; ENSMUSP00000078047 ; ENSMUSG00000064325 .
GeneIDi 15245.
KEGGi mmu:15245.
UCSCi uc009mix.2. mouse.

Organism-specific databases

CTDi 64399.
MGIi MGI:1341847. Hhip.

Phylogenomic databases

eggNOGi COG2133.
GeneTreei ENSGT00530000063250.
HOGENOMi HOG000008644.
HOVERGENi HBG051901.
InParanoidi Q7TN16.
KOi K06231.
OMAi FGDRNGN.
OrthoDBi EOG7CZK54.
PhylomeDBi Q7TN16.
TreeFami TF329059.

Miscellaneous databases

ChiTaRSi HHIP. mouse.
NextBioi 287849.
PROi Q7TN16.
SOURCEi Search...

Gene expression databases

Bgeei Q7TN16.
CleanExi MM_HHIP.
Genevestigatori Q7TN16.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view ]
Pfami PF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
[Graphical view ]
SUPFAMi SSF50952. SSF50952. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein."
    Chuang P.-T., McMahon A.P.
    Nature 397:617-621(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH SHH; IHH AND DHH, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryonic brain.
  4. "Hedgehog interacting protein in the mature brain: membrane-associated and soluble forms."
    Coulombe J., Traiffort E., Loulier K., Faure H., Ruat M.
    Mol. Cell. Neurosci. 25:323-333(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION OF SOLUBLE FORMS.

Entry informationi

Entry nameiHHIP_MOUSE
AccessioniPrimary (citable) accession number: Q7TN16
Secondary accession number(s): Q8C0B0, Q9WU59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi