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Protein

Innate immunity activator protein

Gene

Inava

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion.By similarity

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Innate immunity activator proteinBy similarity
Gene namesi
Name:InavaBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921579. 5730559C18Rik.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517301 – 663Innate immunity activator proteinAdd BLAST663

Proteomic databases

MaxQBiQ7TN12.
PaxDbiQ7TN12.
PRIDEiQ7TN12.

PTM databases

iPTMnetiQ7TN12.
PhosphoSitePlusiQ7TN12.

Expressioni

Gene expression databases

CleanExiMM_5730559C18RIK.

Interactioni

Subunit structurei

Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation. Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113785.

Structurei

3D structure databases

ProteinModelPortaliQ7TN12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili117 – 147Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 170Nuclear localization signal (NLS) 1By similarity7
Motifi332 – 338Nuclear localization signal (NLS) 2By similarity7
Motifi422 – 428Nuclear localization signal (NLS) 3By similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi282 – 309Pro-richAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
HOGENOMiHOG000233699.
HOVERGENiHBG080963.
InParanoidiQ7TN12.
PhylomeDBiQ7TN12.

Family and domain databases

InterProiView protein in InterPro
IPR021774. DUF3338.
PfamiView protein in Pfam
PF11819. DUF3338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TN12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQMPKLNEI PPGRGGPGEP WGEGRWAGPT GPEAARPARG ARGQARGARA
60 70 80 90 100
RWDSWEHSRL PTHPGPGWDQ CSPSFLCAPS SQKLIMESKD EVSDSDSGII
110 120 130 140 150
LQSGPDSPVS PMKELTNAVR KQQRALEARL EACLEELRRL CLREAELTGT
160 170 180 190 200
LPAEYPLKPG EKAPKVRRRI GAAYKLDEWA LHREDPLSSL ERQLALQLQI
210 220 230 240 250
TEAARRLCAE ENLSRQARRQ RKHAALQEEK KLRDLQRCLG DRRRNSEPPP
260 270 280 290 300
TTVPSLGREL SASDDSSLSD GLLLEEEDSQ APKPPPESPA PPSRPLPPQS
310 320 330 340 350
LEGLQPTGPE SGGQERAPIQ NSPWKETSLD HPYEKPRKSS ELSSESSSPA
360 370 380 390 400
TTPQDQPNPS SLWVLDAASY HVVPIRNVPG QRQGRTSAPA TPEMQGRRGQ
410 420 430 440 450
SQSLRVDSFR AGAEGRGRSA FPRRRPTHYT VTVPDSCFTP GKPPLPHPAC
460 470 480 490 500
HSCSEDSGSD VSSISHPTSP GSSSPDISFL RPLCLPEPPR HRGAWGPACG
510 520 530 540 550
RELAPHYSKL LLPAGYFPTG RYVMVAEGHL PPGEWELCRA AVGAAYDEEG
560 570 580 590 600
APLRYQRLVP SHSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS
610 620 630 640 650
SRPHSLDRQG AFRVRSLPPG RESFGRASGP RTQVPPVYVL RRSTDGAPVQ
660
VFVPENGEII SQV
Length:663
Mass (Da):72,693
Last modified:October 1, 2003 - v1
Checksum:i3B1BEB1A8D6298E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti564R → G in BAC25149 (PubMed:16141072).Curated1
Sequence conflicti564R → G in BAC25571 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052416 mRNA. Translation: AAH52416.2.
BC053100 mRNA. Translation: AAH53100.1.
AK006603 mRNA. Translation: BAC25149.1.
AK018917 mRNA. Translation: BAC25571.1.
RefSeqiNP_083148.3. NM_028872.3.
UniGeneiMm.36763.

Genome annotation databases

GeneIDi67313.
KEGGimmu:67313.

Similar proteinsi

Entry informationi

Entry nameiINAVA_MOUSE
AccessioniPrimary (citable) accession number: Q7TN12
Secondary accession number(s): Q7TN27, Q8BGK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: September 27, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot